Inhibitors of the Sodium Pump: Toxins, then Drugs, and now hormones

The influence of some cations on an adenosine triphosphatase from peripheral nerves

1957 • 2,211 citations

Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

1985 • 762 citations

Identification and characterization of a ouabain-like compound from human plasma.

1991 • 759 citations

Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness

1993 • 419 citations

Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence

1985 • 375 citations

Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology

1991 • 313 citations

Mass spectral characterization of an endogenous digitalislike factor from human plasma.

1991 • 228 citations

Physicochemical characterization of a ouabain isomer isolated from bovine hypothalamus.

1993 • 211 citations

Elevated concentrations of endogenous ouabain in patients with congestive heart failure.

1992 • 208 citations

Ouabain Binding Kinetics of the Rat Alpha Two and Alpha Three Isoforms of the Sodium-Potassium Adenosine Triphosphate

1994 • 172 citations

Long-term ouabain administration produces hypertension in rats.

1993 • 162 citations

Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump.

1992 • 159 citations

Purification of an endogenous digitalislike factor from human plasma for structural analysis.

1991 • 156 citations

Aldosterone regulation of gene transcription leading to control of ion transport.

1992 • 140 citations

Molecular basis for the insensitivity of the Monarch (Danaus plexippus) to cardiac glycosides

1992 • 127 citations

Sodium transport and hypertension. Where are we going?

1984 • 114 citations

Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.

1992 • 109 citations

Cardiotonic Steroid Binding to Na,K-ATPase

1983 • 105 citations

Development of an immunoassay for endogenous digitalislike factor.

1991 • 100 citations

Ouabain is secreted by the adrenal gland in awake dogs

1993 • 96 citations

Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions.

1993 • 94 citations

Rat adrenal cortex is a source of a circulating ouabainlike compound.

1992 • 85 citations

Analysis of Amino Acid Residues in the H5-H6 Transmembrane and Extracellular Domains of Na,K-ATPase .alpha. Subunit Identifies Threonine 797 as a Determinant of Ouabain Sensitivity

1994 • 71 citations

Structure-function studies of the Na,K-ATPase.

1994 • 69 citations

A mutation of the drosophila sodium pump α subunit gene results in bang-sensitive paralysis

1994 • 68 citations

Inhibition of α2/α3 sodium pump isoforms potentiates glutamate neurotoxicity

1992 • 56 citations

The Na,K-ATPase : structure-function relationship

1994 • 54 citations

Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance.

1993 • 54 citations

Na,K-ATPase in several tissues of the rat: Tissue-specific expression of subunit mRNAs and enzyme activity

1993 • 46 citations

Identification of two cardiac glycosides as Na(+)-pump inhibitors in rat urine and diet.

1994 • 46 citations

Overview: subunit diversity in the Na,K-ATPase.

1991 • 41 citations

Aldosterone-mediated Na/K-ATPase expression is alpha 1 isoform specific in the renal cortical collecting duct.

1993 • 39 citations

Introduction

1985 • 33 citations

Amino acid residues of the Na,K-ATPase involved in ouabain sensitivity do not bind the sugar moiety of cardiac glycosides.

1993 • 30 citations

Physiologic Rationale for Multiple Sodium Pump Isoforms

1992 • 30 citations

Digitalis-Like Factor and Ouabain-Like Compound in Plasma of Volume-Expanded Dogs

1993 • 28 citations

Dietary sodium stimulates ouabainlike activity in adrenalectomized spontaneously hypertensive rats

1993 • 25 citations

The chronic effects of long-term digoxin administration on activity in rat tissues

1993 • 19 citations

Digoxin-like factors in herbal teas.

1993 • 15 citations

Properties of the Purified Hypothalamic Pituitary NA/K-ATPase Inhibitor

1993 • 11 citations

Effects of Sodium-Transport Inhibition in Human Resistance Arteries

1993 • 7 citations