Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Atlas of Protein Sequence and Structure, 1966.

1967 • 1,463 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.

1980 • 531 citations

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 • 531 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

[49] DNA analysis in the diagnosis of hemoglobin disorders

1981 • 338 citations

THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS

1980 • 306 citations

Localization of the human α-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay

1977 • 282 citations

Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.

1980 • 274 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Homology and concerted evolution at the α1 and α2 loci of human α-globin

1981 • 207 citations

Chromosomal localization of human β globin gene on human chromosome 11 in somatic cell hybrids

1978 • 189 citations

Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination.

1983 • 185 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes.

1979 • 183 citations

The duplicated human alpha globin genes lie close together in cellular DNA.

1978 • 177 citations

Independent recombination events between the duplicated human α globin genes; implications for their concerted evolution

1984 • 157 citations

Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.

1981 • 141 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

The duplicated human α-globin genes: Their relative expression as measured by RNA analysis

1981 • 123 citations

The 3′ untranslated regions of the duplicated human α-globin genes are unexpectedly divergent

1980 • 106 citations

Molecular evolution of the human adult alpha-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences.

1983 • 100 citations

The thalassemia syndromes

1978 • 98 citations

alpha-Thalassemia caused by an unstable alpha-globin mutant.

1983 • 62 citations

Structural and evolutionary analysis of the two chimpanzee α-globin mRNAs

1983 • 41 citations

MULTIPLE HEMOGLOBIN α‐CHAIN LOCI IN MONKEYS, APES, AND MAN *

1974 • 41 citations

Different rates of mRNA translation balance the expression of the two human alpha-globin loci.

1982 • 36 citations

Determination of Alpha Thalassaemia Phenotypes by Messenger RNA Analysis

1980 • 36 citations

Alpha-thalassemia.

1983 • 35 citations

Hematologic and biosynthetic studies in homozygous hemoglobin Constant Spring.

1984 • 34 citations

Detection of Alpha Thalassaemia in Negro Infants

1980 • 29 citations

Alternate Organization of α G-Philadelphia Globin Genes Among U.S. Black and Italian Caucasian Heterozygotes

1984 • 14 citations

a-Thalassemia Caused by an Unstable a-Globin Mutant

1983 • 12 citations

Molecular pathology of alpha-thalassemia.

1982 • 6 citations

Cloning and complete nucleotide sequence of human 5′-α-globin gene

1981 • 6 citations

Beta thalassemia in Sardinia in the result of a nonsense mutation.

1981 • 5 citations