Normal Lysosomal Morphology and Function in LAMP-1-deficient Mice

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.

1991 • 552 citations

Rous sarcoma virus-transformed baby hamster kidney cells express higher levels of asparagine-linked tri- and tetraantennary glycopeptides containing [GlcNAc-beta (1,6)Man-alpha (1,6)Man] and poly-N-acetyllactosamine sequences than baby hamster kidney cells.

1986 • 243 citations

Comparative study of the oligosaccharides released from baby hamster kidney cells and their polyoma transformant by hydrazinolysis.

1984 • 236 citations

Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis

1991 • 210 citations

Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis

1987 • 208 citations

The Two Mannose 6-Phosphate Receptors Transport Distinct Complements of Lysosomal Proteins

1995 • 201 citations

Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.

1988 • 187 citations

Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

1989 • 176 citations

The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1.

1993 • 169 citations

Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens.

1988 • 164 citations

Processing of human cathepsin D in lysosomes in vitro.

1985 • 159 citations

Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.

1990 • 156 citations

Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells.

1995 • 130 citations

Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells.

1988 • 129 citations

Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins

1990 • 120 citations

Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins.

1988 • 120 citations

Lysosome-associated membrane proteins: Characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells

1985 • 118 citations

METACHROMATIC LEUKODYSTROPHY: ARYLSULFATASE-A DEFICIENCY IN SKIN FIBROBLAST CULTURES

1969 • 108 citations

Structure of LEP100, a glycoprotein that shuttles between lysosomes and the plasma membrane, deduced from the nucleotide sequence of the encoding cDNA.

1988 • 104 citations

Biogenesis of lysosomal membranes

1994 • 101 citations

Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein.

1990 • 95 citations

Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D

1996 • 95 citations

Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.

1988 • 95 citations

Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins.

1993 • 93 citations

The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils

1995 • 91 citations

Cathepsin D and beta-hexosaminidase synthesized in the presence of 1-deoxynojirimycin accumulate in the endoplasmic reticulum.

1984 • 84 citations

Structure of Human Lysosomal Membrane Glycoprotein 1

1989 • 70 citations

Mice Deficient in Lysosomal Acid Phosphatase Develop Lysosomal Storage in the Kidney and Central Nervous System

1997 • 69 citations

The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.

1992 • 69 citations

Purification of two glycoproteins expressing β1-6 branched Asn-linked oligosaccharides from metastatic tumour cells

1989 • 62 citations

Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.

1994 • 61 citations

The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins.

1990 • 57 citations

Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes

1989 • 55 citations

The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.

1993 • 55 citations

The permeability of rat liver lysosomes to sugars. Evidence for carrier-mediated facilitated diffusion

1979 • 42 citations

Molecular characterization of P2B/LAMP-1, a major protein target of a metastasis-associated oligosaccharide structure.

1989 • 42 citations

Decrease in polylactosaminoglycans associated with lysosomal membrane glycoproteins during differentiation of CaCo-2 human colonic adenocarcinoma cells.

1989 • 37 citations

Mistargeting of Lysosomal Enzymes in M_r 46000 Mannose 6‐phosphate Receptor‐deficient Mice is Compensated by Carbohydrate‐specific Endocytotic Receptors

1994 • 36 citations

Structure of a gene for a lysosomal membrane glycoprotein (LEP100). Housekeeping gene with unexpected exon organization.

1990 • 32 citations

Purification and Characterization of an 85 kDa Sialoglycoprotein in Liver Lysosomal Membranes1

1992 • 31 citations

Dephosphorylation of the Mannose‐6 Phosphate Recognition Marker is Localized in Late Compartments of the Endocytic Route

1996 • 30 citations

Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network

1993 • 28 citations

t-Complex-Associated Embryonic Surface Antigen Homologous to mLAMP-1

1997 • 8 citations