Gap junctions: the “kiss of death” and the “kiss of life”

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

GENETICS OF HUMAN CELL LINES, IV. DNA-MEDIATED HERITABLE TRANSFORMATION OF A BIOCHEMICAL TRAIT

1962 • 493 citations

Morphological and biochemical characterization and analysis of apoptosis

1997 • 478 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

In VitroEvidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSVtkRetroviral Gene Therapy

1993 • 425 citations

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

1996 • 418 citations

Early Detection of Apoptosis Using a Fluorescent Conjugate of Annexin V

1997 • 376 citations

Ganciclovir

1996 • 366 citations

Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation.

1991 • 366 citations

Gap junctional communication and carcinogenesis

1990 • 310 citations

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors.

1994 • 302 citations

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

1996 • 260 citations

The cell-cell channel in the control of growth

1992 • 254 citations

How to Close a Gap Junction Channel: Efficacies and Potencies of Uncoupling Agents

2003 • 222 citations

Gap junction function and cancer.

1993 • 214 citations

The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

1995 • 209 citations

Plasma Membrane Alterations and Cytoskeletal Changes in Apoptosis

1997 • 206 citations

In vivo growth of C6 glioma cells transfected with connexin43 cDNA.

1992 • 172 citations

Role of connexin (gap junction) genes in cell growth control and carcinogenesis

1999 • 161 citations

Thymidine kinase-mediated killing of rat brain tumors

1993 • 136 citations

Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein.

1992 • 131 citations

Increased surface phosphatidylserine is an early marker of neuronal apoptosis

1997 • 116 citations

Gap junctional communication and neoplastic transformation.

1993 • 96 citations

The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions

1997 • 96 citations

'Bystander killing' induces apoptosis and is inhibited by forskolin.

1995 • 92 citations

Bystander Tumoricidal Effect in the Treatment of Experimental Brain Tumors

1994 • 88 citations

Gene Therapy for Gliomas: Molecular Targets, Adenoviral Vectors, and Oncolytic Adenoviruses

1999 • 87 citations

Exchange between hamster cells in culture

1968 • 74 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Chemical Agents Selective for Mutant or Normal Cultured Fibroblasts in Mixed and Heterozygote Cultures

1971 • 72 citations

Swelling and death of neuronal cells by lactic acid

1993 • 68 citations

Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect.

1997 • 67 citations

Biochemically marked variants of the syrian hamster fibroblast cell line BHK21 and its derivatives

1965 • 61 citations

Connexins Are Expressed in Primary Brain Tumors and Enhance the Bystander Effect in Gene Therapy

1999 • 59 citations

Morphometric and colorimetric analyses of human tumor cell line growth and drug sensitivity in soft agar culture.

1991 • 43 citations

The discovery of metabolic co-operation

1999 • 37 citations

Roots. Use of the HPRT gene and the HAT selection technique in DNA‐mediated transformation of mammalian cells: First steps toward developing hybridoma techniques and gene therapy

1992 • 30 citations

A more potent bystander cytocidal effect elicited by tumor cells expressing the herpes simplex virus—thymidine kinase gene than by fibroblast virus—producer cells in vitro

1995 • 20 citations

Purification of cell populations from human fetal brain using flow cytometric techniques

1995 • 17 citations

Purification of Human Fetal Hippocampal Neurons by Flow Cytometry for Transplantation

1998 • 9 citations

Deleted Work

1955 • 0 citations