Cyclin G2 Associates with Protein Phosphatase 2A Catalytic and Regulatory B′ Subunits in Active Complexes and Induces Nuclear Aberrations and a G1/S Phase Cell Cycle Arrest

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,654 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,268 citations

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.

1988 • 1,241 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Transfecting Mammalian Cells: Optimization of Critical Parameters Affecting Calcium-Phosphate Precipitate Formation

1996 • 862 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

1996 • 586 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Cell cycle regulation by the Cdc25 phosphatase family

2000 • 433 citations

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

1998 • 415 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Centrosome-Dependent Exit of Cytokinesis in Animal Cells

2001 • 396 citations

Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- <scp>d</scp> -aspartate receptor

1999 • 377 citations

The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

1996 • 371 citations

Ceramide Induces Bcl2 Dephosphorylation via a Mechanism Involving Mitochondrial PP2A

1999 • 340 citations

Centrosomes Enhance the Fidelity of Cytokinesis in Vertebrates and Are Required for Cell Cycle Progression

2001 • 340 citations

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle

1990 • 339 citations

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G ₁ into S Phase

2001 • 336 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules

1999 • 293 citations

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A

1999 • 292 citations

CDC55, a Saccharomyces cerevisiae Gene Involved in Cellular Morphogenesis: Identification, Characterization, and Homology to the B Subunit of Mammalian Type 2A Protein Phosphatase

1991 • 276 citations

Inhibitors of protein kinases and phosphatases

1994 • 268 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

Targets of cyclin-dependent protein kinases

1993 • 240 citations

Characterization of a Novel Giant Scaffolding Protein, CG-NAP, That Anchors Multiple Signaling Enzymes to Centrosome and the Golgi Apparatus

1999 • 239 citations

A Signaling Complex of Ca ²⁺ -Calmodulin-Dependent Protein Kinase IV and Protein Phosphatase 2A

1998 • 233 citations

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

1990 • 221 citations

Regulation of transcription by proteins that control the cell cycle

1997 • 220 citations

Control of the G1/S transition.

1997 • 219 citations

Identification of a New Family of Protein Phosphatase 2A Regulatory Subunits

1995 • 219 citations

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

1993 • 215 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

1992 • 191 citations

A Protein Phosphatase Methylesterase (PME-1) Is One of Several Novel Proteins Stably Associating with Two Inactive Mutants of Protein Phosphatase 2A

1999 • 186 citations

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

1993 • 186 citations

Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae.

1992 • 180 citations

Neuronal cdc2-like kinase

1995 • 179 citations

Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits

1998 • 175 citations

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit

1999 • 173 citations

p21^Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

1999 • 171 citations

Separation of PP2A Core Enzyme and Holoenzyme with Monoclonal Antibodies against the Regulatory A Subunit: Abundant Expression of Both Forms in Cells

1997 • 164 citations

High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

1996 • 163 citations

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.

1991 • 162 citations

Cyclin G1 and Cyclin G2 Comprise a New Family of Cyclins with Contrasting Tissue-specific and Cell Cycle-regulated Expression

1996 • 159 citations

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

1993 • 158 citations

Regulation of Protein Phosphatase 2A Activity by Caspase-3 during Apoptosis

1998 • 153 citations

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

1993 • 149 citations

Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.

1995 • 149 citations

Cyclins, cyclin‐dependent kinases and differentiation

1997 • 143 citations

Autoregulation of Protein Phosphatase Type 2A Expression

1998 • 140 citations

Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

1993 • 135 citations

Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites.

1995 • 132 citations

Cdc55p, the B-Type Regulatory Subunit of Protein Phosphatase 2A, Has Multiple Functions in Mitosis and Is Required for the Kinetochore/Spindle Checkpoint in Saccharomyces cerevisiae

1997 • 131 citations

Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

1997 • 130 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Characterisation of human cyclin G1 and G2: DNA damage inducible genes.

1996 • 128 citations

Cyclin G2 Is Up-regulated during Growth Inhibition and B Cell Antigen Receptor-mediated Cell Cycle Arrest

1997 • 124 citations

Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.

1993 • 121 citations

Identification of a Novel Protein Phosphatase 2A Regulatory Subunit Highly Expressed in Muscle

1996 • 121 citations

Molecular Genetic Analysis of Rts1p, a B′ Regulatory Subunit of Saccharomyces cerevisiae Protein Phosphatase 2A

1997 • 111 citations

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.

1994 • 109 citations

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2

1994 • 107 citations

Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.

1993 • 106 citations

Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments

1997 • 105 citations

p53-Dependent Association between Cyclin G and the B′ Subunit of Protein Phosphatase 2A

1996 • 103 citations

Vimentin Dephosphorylation by Protein Phosphatase 2A Is Modulated by the Targeting Subunit B55

1999 • 100 citations

Saccharomyces cerevisiae Homologs of Mammalian B and B′ Subunits of Protein Phosphatase 2A Direct the Enzyme to Distinct Cellular Functions

1997 • 100 citations

Cyclins and the G2/M transition.

1997 • 99 citations

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

1999 • 99 citations

Regulation of Endosome Sorting by a Specific PP2A Isoform

1998 • 99 citations

Activation of a PP2A-like phosphatase and dephosphorylation of τ protein characterize onset of the execution phase of apoptosis

1998 • 98 citations

Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells

1997 • 94 citations

Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos

1996 • 92 citations

Cyclin I: A New Cyclin Encoded by a Gene Isolated from Human Brain

1995 • 79 citations

Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits.

1992 • 78 citations

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits

1996 • 77 citations

Purification and Characterization of Ceramide-Activated Protein Phosphatases

1998 • 72 citations

A Method for Isolation and Purification of Specific Antibodies to a Protein Fused to the GST

1996 • 72 citations

NH2-terminal modification of the phosphatase 2A catalytic subunit allows functional expression in mammalian cells.

1992 • 67 citations

Protein dephosphorylation and the intracellular control of the cell number

1999 • 61 citations

Fostriecin-mediated G2-M-phase growth arrest correlates with abnormal centrosome replication, the formation of aberrant mitotic spindles, and the inhibition of serine/threonine protein phosphatase activity.

1998 • 56 citations

Caspase activation by BCR cross‐linking in immature B cells: differential effects on growth arrest and apoptosis

1999 • 52 citations

Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated Cells

1995 • 50 citations

Isolation and Characterization of par1+ and par2+: Two Schizosaccharomyces pombe Genes Encoding B′ Subunits of Protein Phosphatase 2A

2000 • 39 citations

The role of protein phosphatase type-2A in the cell cycle: initiation of the G2/M transition

1995 • 38 citations

Assembly of the Truncated Immunoglobulin Heavy Chain Dμ into Antigen Receptor–Like Complexes in Pre-B Cells but Not in B Cells

1996 • 37 citations

Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells

1998 • 36 citations

[14] Direct identification of microtubule-associated proteins be selective extraction of cultured cells

1986 • 36 citations

Gene structure and chromosomal localization of mouse cyclin G2 (Ccng2)

1999 • 16 citations