Structural insights into Alzheimer filament assembly pathways based on site‐directed mutagenesis and S‐glutathionylation of three‐repeat neuronal Tau protein

Novel Proteinaceous Infectious Particles Cause Scrapie

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A protein factor essential for microtubule assembly.

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Neurodegenerative Tauopathies

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Sickle Cell Anemia, a Molecular Disease

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Dithiothreitol, a New Protective Reagent for SH Groups^*

1964 • 1,933 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

1999 • 1,070 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

1999 • 716 citations

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1993 • 702 citations

Amyloid diseases: Abnormal protein aggregation in neurodegeneration

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Defective protein folding as a basis of human disease

1995 • 540 citations

RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments

1996 • 502 citations

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

1988 • 476 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE

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Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction

1996 • 387 citations

Rapid Assembly of Alzheimer-like Paired Helical Filaments from Microtubule-Associated Protein Tau Monitored by Fluorescence in Solution

1998 • 380 citations

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

1995 • 347 citations

Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.

1997 • 343 citations

Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias

2000 • 337 citations

Protein misfolding and disease; protein refolding and therapy

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A nucleated assembly mechanism of Alzheimer paired helical filaments

1998 • 327 citations

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

1994 • 326 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

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Tau Mutations Cause Frontotemporal Dementias

1998 • 267 citations

Conformational changes and disease — serpins, prions and Alzheimer's

1998 • 241 citations

Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

2003 • 233 citations

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

2005 • 232 citations

Oxidative Stress and Redox‐Active Iron in Alzheimer's Disease

2004 • 202 citations

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases.

1988 • 201 citations

Prionics or The kinetic basis of prion diseases

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Two Separate 18-Amino Acid Domains of Tau Promote the Polymerization of Tubulin

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The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

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The chemistry of scrapie infection: implications of the ‘ice 9’ metaphor

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Tau protein and neurodegeneration

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Tau Protein in Normal and Alzheimer's Disease Brain: An Update*

1999 • 158 citations

Assembly of Alzheimer‐like filaments from full‐length tau protein

1994 • 154 citations

Oxidative Regulation of Fatty Acid-Induced Tau Polymerization

2000 • 138 citations

Modeling Tau Polymerization in Vitro: A Review and Synthesis

2003 • 114 citations

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.

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Evidence for two distinct binding sites for tau on microtubules

2004 • 107 citations

The Microtubule-Associated Protein Tau Cross-Links to Two Distinct Sites on Each α and β Tubulin Monomer via Separate Domains

1998 • 102 citations

Formation of aberrant phosphotau fibrillar polymers in neural cultured cells

2002 • 101 citations

The microtubule-binding fragment of microtubule-associated protein-2: location of the protease-accessible site and identification of an assembly-promoting peptide.

1989 • 98 citations

Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease

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Microtubule-dependent Oligomerization of Tau

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Polymerization of Microtubule-associated Protein Tau under Near-physiological Conditions

1995 • 78 citations

Immunocytochemical properties of Alzheimer straight filaments

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Transglutaminase and the Neuronal Cytoskeleton in Alzheimer's Disease

1986 • 46 citations

Multisite phosphorylation of τ proteins from rat brain

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Redox modulation of tau and microtubule-associated protein-2 by the glutathione/glutaredoxin reductase system

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Regional Kinetic Constants for Blood–Brain Barrier Pyruvic Acid Transport in Conscious Rats by the Monocarboxylic Acid Carrier

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Isolation of a phosphorylated soluble Tau fraction from Alzheimer's disease brain

1995 • 22 citations

In Vitro Assembly of Alzheimer-like Filaments

2002 • 19 citations

In Vitro Polymerization of Embryonic MAP-2c and Fragments of the MAP-2 Microtubule Binding Region into Structures Resembling Paired Helical Filaments

1996 • 19 citations

Oxidized and phosphorylated synthetic peptides corresponding to the second and third tubulin‐binding repeats of the τ protein reveal structural features of paired helical filament assembly

1997 • 17 citations

Disulfide-Cross-Linked Tau and MAP2 Homodimers Readily Promote Microtubule Assembly

1999 • 16 citations

Self-Assembly of the Brain MAP-2 Microtubule-Binding Region into Polymeric Structures Resembling Alzheimer Filaments

1996 • 12 citations

Understanding the hyperphosphorylation of tau in Alzheimer's disease: Importance of examining site-specific phosphorylation in non-disease systems

1995 • 1 citations