Protein–protein interfaces: mimics and inhibitors

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Apoptosis Signaling

2000 • 1,290 citations

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

2000 • 1,170 citations

An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides

2000 • 951 citations

Tryptophan zippers: Stable, monomeric β-hairpins

2001 • 701 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

2001 • 546 citations

Peptide and Protein Recognition by Designed Molecules

2000 • 530 citations

Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex

1999 • 530 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Site-directed ligand discovery

2000 • 446 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Exploiting the Basis of Proline Recognition by SH3 and WW Domains: Design of N-Substituted Inhibitors

1998 • 309 citations

Toward Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix

2001 • 308 citations

A structural view of mitochondria-mediated apoptosis.

2001 • 307 citations

X-ray analysis (1. 4-Å resolution) of avian pancreatic polypeptide: Small globular protein hormone

1981 • 279 citations

Chalcone Derivatives Antagonize Interactions between the Human Oncoprotein MDM2 and p53

2000 • 269 citations

Phage display in pharmaceutical biotechnology

2000 • 254 citations

Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels

1998 • 234 citations

Antagonists of protein–protein interactions

2000 • 229 citations

Bcl-2 family proteins as targets for anticancer drug design

2000 • 204 citations

Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors

2000 • 189 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Screening for receptor ligands using large libraries of peptides linked to the C terminus of the lac repressor.

1992 • 178 citations

Regulation of apoptosis by BH3 domains in a cell-free system

1997 • 172 citations

Analysis of PDZ Domain-Ligand Interactions Using Carboxyl-terminal Phage Display

2000 • 167 citations

Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.

2001 • 162 citations

Forming stable helical peptides using natural and artificial amino acids

1999 • 161 citations

Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

2000 • 139 citations

A Minimal Peptide Scaffold for β-Turn Display: Optimizing a Strand Position in Disulfide-Cyclized β-Hairpins

2000 • 135 citations

Highly Specific DNA Recognition by a Designed Miniature Protein

1999 • 129 citations

Improving SH3 domain ligand selectivity using a non-natural scaffold

2000 • 114 citations

Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its anti-apoptotic activity.

2000 • 92 citations

Designing Small-Molecule Switches for Protein-Protein Interactions

2000 • 91 citations

Chemical ligands, genomics and drug discovery

2000 • 89 citations

Selective disruption of protein aggregation by cyclodextrin dimers

2000 • 70 citations

Design of growth factor antagonists with antiangiogenic and antitumor properties

2000 • 55 citations

Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1

2001 • 38 citations

Minimalist, Alanine-Based, Helical Protein Dimers Bind to Specific DNA Sites

2000 • 32 citations