Common gene signature of cancer and longevity

Network biology: understanding the cell's functional organization

2004 • 7,596 citations

Lethality and centrality in protein networks

2001 • 5,197 citations

Cellular senescence: when bad things happen to good cells

2007 • 3,933 citations

BioGRID: a general repository for interaction datasets

2005 • 3,858 citations

A census of human cancer genes

2004 • 3,190 citations

The human disease network

2007 • 3,104 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

2002 • 944 citations

Cellular senescence as a tumor-suppressor mechanism

2001 • 847 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Inparanoid: a comprehensive database of eukaryotic orthologs

2004 • 756 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at Senescence

2006 • 542 citations

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

2005 • 527 citations

A systematic RNAi screen for longevity genes in C. elegans

2005 • 505 citations

Mechanisms of aging: public or private?

2002 • 500 citations

Cancer and ageing: rival demons?

2003 • 498 citations

Global topological features of cancer proteins in the human interactome

2006 • 492 citations

The quest for genetic determinants of human longevity: challenges and insights

2006 • 490 citations

Osprey: a network visualization system

2003 • 475 citations

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

2007 • 463 citations

The Naked Mole-Rat: A New Long-Living Model for Human Aging Research

2005 • 443 citations

Cellular senescence as a tumor-suppressor mechanism

2001 • 362 citations

Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress

2007 • 336 citations

Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity

2003 • 297 citations

Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth

2006 • 239 citations

Evolutionary conservation of regulated longevity assurance mechanisms

2007 • 202 citations

Protein networks, pleiotropy and the evolution of senescence

2004 • 178 citations

Cancer in rodents: does it tell us about cancer in humans?

2005 • 168 citations

DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans

2007 • 160 citations

Loss of pregnancy‐associated plasma protein A extends lifespan in mice

2007 • 147 citations

Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry

2007 • 134 citations

Loss of Glial Lazarillo, a Homolog of Apolipoprotein D, Reduces Lifespan and Stress Resistance in Drosophila

2006 • 131 citations

Overexpression of a Drosophila Homolog of Apolipoprotein D Leads to Increased Stress Resistance and Extended Lifespan

2006 • 128 citations

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice

2005 • 128 citations

Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities

2007 • 118 citations

Genes encoding longevity: from model organisms to humans

2008 • 118 citations

Functional and evolutionary inference in gene networks: does topology matter?

2006 • 117 citations

From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing

2004 • 108 citations

p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions

2005 • 105 citations

Tumour‐suppression activity of the proapoptotic regulator Par4

2005 • 103 citations

Biology of Aging and Cancer

2007 • 101 citations

Evolutionary conservation of domain-domain interactions.

2006 • 97 citations

Longevity network: Construction and implications

2006 • 95 citations

WRN at telomeres: implications for aging and cancer

2007 • 92 citations

Introduction: The adversities of aging

2006 • 76 citations

Cancer Resistance in Transgenic Mice Expressing the SAC Module of Par-4

2007 • 71 citations

Gene expression and DNA repair in progeroid syndromes and human aging

2005 • 66 citations

How genetic analysis tests theories of animal aging

2006 • 62 citations

Carcinogenesis and aging 20 years after: Escaping horizon

2008 • 62 citations

A more efficient search strategy for aging genes based on connectivity

2004 • 55 citations

Genetic alterations in accelerated ageing syndromes

2004 • 53 citations

Science of Cancer and Aging

2007 • 49 citations

Metabolic homeostasis and tissue renewal are dependent on β1,6GlcNAc-branched N-glycans

2007 • 48 citations

αMUPA mice: a transgenic model for longevity induced by caloric restriction

2004 • 39 citations

Analyses of human–chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging

2007 • 36 citations

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation

2007 • 33 citations

From Disease-Oriented to Aging/Longevity-Oriented Studies

2006 • 28 citations

Are cancer and ageing different sides of the same coin?

2008 • 15 citations

Theoretical Paper:Exploring Overlooked Natural Mitochondria-Rejuvenative Intervention: The Puzzle of Bowhead Whales and Naked Mole Rats

2007 • 13 citations