From Disease-Oriented to Aging/Longevity-Oriented Studies

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Longevity, senescence and the genome

1995 • 1,390 citations

An integrated epigenetic and genetic approach to common human disease

2004 • 442 citations

Impact of aging on DNA methylation

2003 • 421 citations

S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production

2004 • 401 citations

DNA Methylation, Cancer Susceptibility, and Nutrient Interactions

2004 • 392 citations

Induction of DNA methylation and gene silencing by short interfering RNAs in human cells

2004 • 372 citations

Age-Associated Activation of Epigenetically Repressed Genes in the Mouse

2003 • 196 citations

Aberrant methylations in cancer cells: Where do they come from?

2005 • 187 citations

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

2004 • 179 citations

Aging, cancer and nutrition: the DNA methylation connection

2003 • 168 citations

DNA Methylation and Atherosclerosis

2002 • 165 citations

DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila

2004 • 119 citations

DNA Methylation, Smooth Muscle Cells, and Atherogenesis

2003 • 111 citations

Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction

2002 • 110 citations

Targeting DNA methylation in cancer

2003 • 97 citations

Non-prostaglandin eicosanoids in fever and anapyrexia

2004 • 37 citations

p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid

2004 • 16 citations

Deleted Work

1955 • 0 citations