IPEX as a Result of Mutations in FOXP3

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

2002 • 703 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Defective regulatory and effector T cell functions in patients with FOXP3 mutations

2006 • 508 citations

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy

1982 • 436 citations

Regulation of immunity by self-reactive T cells

2005 • 306 citations

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

2006 • 267 citations

FOXP3 modifies the phenotypic and functional properties of regulatory T cells

2007 • 262 citations

Treatment of the Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX) by Allogeneic Bone Marrow Transplantation

2001 • 259 citations

A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA) leads to the IPEX syndrome

2001 • 237 citations

Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning

2006 • 168 citations

Successful Use of the New Immune-suppressor Sirolimus in IPEX (Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked Syndrome)

2005 • 116 citations

Mutational Analysis of the FOXP3 Gene and Evidence for Genetic Heterogeneity in the Immunodysregulation, Polyendocrinopathy, Enteropathy Syndrome

2003 • 107 citations

Manifestations and linkage analysis in X-linked autoimmunity-immunodeficiency syndrome

2000 • 89 citations

A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy

1993 • 86 citations

Regulatory T cells in human autoimmune diseases

2006 • 74 citations

Clinical and molecular findings in IPEX syndrome

2005 • 49 citations

A Potential Screening Tool for IPEX Syndrome

2007 • 43 citations