Transactivation of the Human Renin Promoter by the Cyclic AMP/Protein Kinase A Pathway Is Mediated by Both cAMP-responsive Element Binding Protein-1 (CREB)-dependent and CREB-independent Mechanisms in Calu-6 Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Current protocols in molecular biology

1988 • 4,543 citations

Some statistical methods useful in circulation research.

1980 • 3,978 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Hypertension : pathophysiology, diagnosis, and management

1995 • 1,895 citations

The insulin signaling system.

1994 • 1,733 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Morphology, physiology, and molecular biology of renin secretion

1990 • 610 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

1993 • 301 citations

Structural determinants for transcriptional activation by cAMP-responsive DNA elements.

1988 • 258 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes.

1992 • 230 citations

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

1991 • 229 citations

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

1991 • 224 citations

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo.

1992 • 208 citations

Transcriptional regulation by CREB and its relatives

1993 • 197 citations

Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase.

1987 • 194 citations

Signal transduction and gene control: the cAMP pathway.

1992 • 142 citations

Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.

1993 • 137 citations

The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.

1990 • 133 citations

Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein

1991 • 123 citations

Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice.

1992 • 103 citations

Angiotensin II receptors: protein and gene structures, expression and potential pathological involvements

1996 • 85 citations

cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chorionic cells.

1994 • 75 citations

Identification of negative and positive regulatory elements in the human renin gene

1989 • 75 citations

Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei.

1994 • 68 citations

Angiotensin II signalling events mediated by tyrosine phosphorylation

1996 • 56 citations

Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor

1991 • 55 citations

Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element-binding protein (CREB) and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif

1996 • 52 citations

Renin in blood vessels in human pulmonary tumors. An immunohistochemical and biochemical study.

1988 • 44 citations

Endogenous Human Renin Expression and Promoter Activity in CALU-6, a Pulmonary Carcinoma Cell Line

1995 • 43 citations

Isolation and Characterization of Renin-Producing Human Chorionic Cells in Culture

1988 • 42 citations

Identification of proteins that interact with CREB during differentiation of F9 embryonal carcinoma cells

1993 • 41 citations

Opposite regulation of renin gene expression by cyclic AMP and calcium in isolated mouse juxtaglomerular cells

1995 • 41 citations

Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells.

1987 • 37 citations

Activating transcription factor-1 is a specific antagonist of the cyclic adenosine 3'.5'-monophosphate (cAMP) response element-binding protein-1-mediated response to cAMP.

1995 • 35 citations

Renin gene promoter activity in GC cells is regulated by cAMP and thyroid hormone through Pit-1-dependent mechanisms.

1994 • 34 citations

Isolation of renin-producing human cells by transfection with three simian virus 40 mutants.

1985 • 34 citations

Pituitary-specific transcription factor (Pit-1) binding site in the human renin gene 5'-flanking DNA stimulates promoter activity in placental cell primary cultures and pituitary lactosomatotropic cell lines.

1994 • 27 citations

Identification of Cyclic AMP Response Element in the Human Renin Gene

1994 • 23 citations

Identification and characterization of adenosine A1 receptor-cAMP system in human glomeruli

1993 • 17 citations

A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells

1994 • 15 citations

Function of human renin proximal promoter DNA

1994 • 15 citations

Renin in human fetal lung ??? a biochemical and immunohistochemical study

1988 • 12 citations