Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles

1999 • 1,024 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

2001 • 882 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Krox-20 controls myelination in the peripheral nervous system

1994 • 761 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Impaired Recognition Memory in Rats after Damage to the Hippocampus

2000 • 718 citations

Experience-Dependent Gene Expression in the Rat Hippocampus after Spatial Learning: A Comparison of the Immediate-Early GenesArc, c-fos, andzif268

2001 • 680 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

2000 • 660 citations

Rapid and selective induction of BDNF expression in the hippocampus during contextual learning

2000 • 616 citations

Song presentation induces gene expression in the songbird forebrain.

1992 • 612 citations

The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate GyrusIn Vivo

2000 • 609 citations

Making New Connections

1999 • 601 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Postsynaptic protein phosphorylation and LTP

2000 • 559 citations

The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus

1999 • 542 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

1999 • 520 citations

Ets transcription factors: nuclear effectors of the Ras–MAP-kinase signaling pathway

1998 • 504 citations

Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training

1997 • 484 citations

Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)

1996 • 479 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

1999 • 445 citations

Activation of immediate early genes and memory formation

1999 • 413 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement

1993 • 345 citations

Egr transcription factors in the nervous system

1997 • 344 citations

Cellular imaging of zif268 expression in the hippocampus and amygdala during contextual and cued fear memory retrieval: selective activation of hippocampal CA1 neurons during the recall of contextual memories.

2001 • 344 citations

Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation

1998 • 335 citations

Immediate-Early Genes and Synaptic Function

1998 • 334 citations

Cellular Imaging ofzif268Expression in the Hippocampus and Amygdala during Contextual and Cued Fear Memory Retrieval: Selective Activation of Hippocampal CA1 Neurons during the Recall of Contextual Memories

2001 • 312 citations

Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade

2000 • 312 citations

Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c -fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices

1999 • 310 citations

DNA-Binding Specificity of NGFI-A and Related Zinc Finger Transcription Factors

1995 • 304 citations

Constitutive expression of zif268 in neocortex is regulated by synaptic activity.

1991 • 300 citations

Correlations between immediate early gene induction and the persistence of long-term potentiation

1993 • 297 citations

Specific and Differential Activation of Mitogen-Activated Protein Kinase Cascades by Unfamiliar Taste in the Insular Cortex of the Behaving Rat

1998 • 289 citations

Multiple Pituitary and Ovarian Defects in Krox-24 (NGFI-A, Egr-1)-Targeted Mice

1998 • 277 citations

Localized neuronal activation in the zebra finch brain is related to the strength of song learning

2000 • 258 citations

Arg3.1/Arc mRNA Induction by Ca²⁺and cAMP Requires Protein Kinase A and Mitogen-Activated Protein Kinase/Extracellular Regulated Kinase Activation

2001 • 257 citations

The role of immediate early genes in the stabilization of long-term potentiation

1991 • 245 citations

A role for immediate-early transcription factors in learning and memory

1996 • 187 citations

Spatial and temporal changes in signal transduction pathways during LTP

1994 • 184 citations

Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus

1992 • 168 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

In VivoExpression and Regulation of Elk-1, a Target of the Extracellular-Regulated Kinase Signaling Pathway, in the Adult Rat Brain

1998 • 155 citations

Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.

1994 • 144 citations

Specific induction of early growth response gene 1 in the lateral nucleus of the amygdala following contextual fear conditioning in rats

2000 • 122 citations

Patterns of expression of the immediate-early gene egr-1 in the accessory olfactory bulb of female mice exposed to pheromonal constituents of male urine

1999 • 119 citations

Associative learning and stimulus novelty influence the song-induced expression of an immediate early gene in the canary forebrain.

1995 • 118 citations

Molecular Mechanisms of Long-Term Potentiation in the Insular CortexIn Vivo

1999 • 114 citations

Defective bone formation in Krox-20 mutant mice

1996 • 108 citations

Neuronal activity in primate visual cortex assessed by immunostaining for the transcription factor Zif268

1995 • 105 citations

Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268.

1994 • 103 citations

Subfield‐specific immediate early gene expression associated with hippocampal long‐term potentiation in vivo

2001 • 101 citations

Krox20 may play a key role in the stabilization of long-term potentiation

1995 • 100 citations

Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task

1998 • 100 citations

Inhibition of protein synthesis in the dentate gyrus, but not the entorhinal cortex, blocks maintenance of long-term potentiation in rats

1989 • 95 citations

Expression of the nerve growth factor-regulated NGFI-A and NGFI-B genes in the developing rat

1990 • 93 citations

Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus

2000 • 93 citations

High basal expression of the immediate early gene in cortical layers IV and VI, in CA1 and in the corpus striatum - an in situ hybridization study

1991 • 84 citations

Expression of the Transcription Factor Zif268 in the Temporal Cortex of Monkeys during Visual Paired Associate Learning

1996 • 74 citations

Synapsin I and syntaxin 1B: Key elements in the control of neurotransmitter release are regulated by neuronal activation and long-term potentiation in vivo

1997 • 70 citations

Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes

1989 • 67 citations

C-fos protooncogene expression in rat brain after long-term training of two-way active avoidance reaction

1992 • 66 citations

Gene expression profiles during long‐term memory consolidation

2001 • 57 citations

Localization of the NGFI-A protein in the rat brain

1990 • 55 citations

Complex patterns of immediate early gene induction in rat brain following brightness discrimination training and pseudotraining

1997 • 48 citations

Developmental expression of the transcription factor zif268 in rat brain

1994 • 45 citations

Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation

2000 • 44 citations

Regulated expression of the neuronal calcium sensor-1 gene during long-term potentiation in the dentate gyrus in vivo

2001 • 39 citations

Alterations in the expression of specific glutamate receptor subunits following hippocampal LTP in vivo.

1996 • 35 citations

Increase in Syntaxin 1B mRNA in Hippocampal and Cortical Circuits During Spatial Learning Reflects a Mechanism of Trans-synaptic Plasticity Involved in Establishing a Memory Trace

1998 • 30 citations

Brain Structure and Task‐specific Increase in Expression of the Gene Encoding Syntaxin 1B During Learning in the Rat: A Potential Molecular Marker for Learning‐induced Synaptic Plasticity in Neural Networks

1996 • 30 citations

Molecular mechanisms of LTP in the insular cortex in vivo

1999 • 4 citations