Platelets as a model for neurones?

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Identification and assay of serotonin in brain.

1956 • 850 citations

Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.

1986 • 671 citations

Platelets in Biology and Pathology

1981 • 644 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Typical and atypical antidepressants. Molecular mechanisms.

1982 • 315 citations

Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation

1980 • 313 citations

Platelets in biology and pathology

1977 • 308 citations

Platelets: A Multidisciplinary Approach

1979 • 275 citations

Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding

1979 • 264 citations

Demonstration of specific high affinity binding sites for [3H] imipramine in human brain

1980 • 258 citations

Alpha-Adrenergic Receptor Subtypes

1980 • 255 citations

Chapter 4 Coexistence of neuronal messengers — an overview

1986 • 223 citations

Novel α2-adrenoreceptors primarily responsible for inducing human platelet aggregation

1979 • 208 citations

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

1985 • 206 citations

The platelets physiology and pharmacology

1986 • 203 citations

Demonstration of specific “high affinity” binding sites for [3H] imipramine on human platelets

1980 • 198 citations

GABAergic mechanisms in the mammalian periphery

1987 • 197 citations

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

1982 • 165 citations

Ultrastructural Localization of 5-Hydroxy-tryptamine in Blood Platelets

1966 • 163 citations

Selective inhibitors of monoamine oxidase A and B: Biochemical, pharmacological, and clinical properties

1984 • 152 citations

Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites.

1983 • 145 citations

High-affinity binding of 3H-imipramine in brain and platelets and its relevance to the biochemistry of affective disorders

1981 • 145 citations

Human platelet α2-adrenergic receptors: Labeling with 3H-yohimbine, a selective antagonist ligand

1981 • 142 citations

CONTENT AND SUBCELLULAR LOCALIZATION OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE IN HUMAN AND ANIMAL BLOOD PLATELETS: MONOAMINE DISTRIBUTION BETWEEN PLATELETS AND PLASMA

1979 • 142 citations

UPTAKE OF 5‐HYDROXYTRYPTAMINE BY PLATELETS

1961 • 126 citations

α2-adrenoreceptors on human platelets: Selective labelling by [3H]clonidine and [3H]yohimbine and competetive inhibition by antidepressant drugs

1981 • 117 citations

Absorption of serotonin (5‐hydroxytryptamine) and histamine by dog platelets

1954 • 115 citations

Platelets as Pharmacologic Models for the Receptors and Biochemistry of Monoaminergic Neurons

1985 • 107 citations

Modification of sympathetic function. Pharmacological depletion of catecholamine stores.

1966 • 104 citations

Interactions of Agonists with Platelet α₂-Adrenergic Receptors

1982 • 102 citations

Ultrastructural demonstration of nonsynaptic release sites in the central nervous system of the snail lymnaea stagnalis, the insect periplaneta americana, and the rat

1986 • 99 citations

Subcellular Localization of 5-Hydroxytryptamine and Histamine in Blood Platelets

1967 • 97 citations

Activation of V1-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets

1986 • 97 citations

Uranaffin reaction: a new cytochemical technique for the localization of adenine nucleotides in organelles storing biogenic amines.

1977 • 91 citations

Chapter 3 The diffuse neuroendocrine system: peptides, amines, placodes and the APUD theory

1986 • 89 citations

Allosteric Interaction Between the Site Labeled by [³H]Imipramine and the Serotonin Transporter in Human Platelets

1987 • 84 citations

Chapter 13 Purines as cotransmitters in adrenergic and cholinergic neurones

1986 • 82 citations

Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules

1979 • 73 citations

Platelets as models for monoaminergic neurons.

1978 • 68 citations

Blood Platelets as Models for Neurons: Uses and Limitations

1980 • 66 citations

Release of serotonin from blood platelets by reserpine in vitro.

1957 • 65 citations

The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1–methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) and structurally related compounds

1986 • 65 citations

Micelle Formation between 5-Hydroxytryptamine and Adenosine Triphosphate in Platelet Storage Organelles

1969 • 64 citations

Substituted tetrahydro-β-carbolines are possible candidates as endogenous ligand of the [3H]Imipramine recognition site

1984 • 64 citations

Bioenergetics of serotonin transport by membrane vesicles derived from platelet dense granules.

1982 • 64 citations

Regulated Secretory Pathways of Neurons and Their Relation to the Regulated Secretory Pathway of Endocrine Cells

1987 • 62 citations

Ca2+ as messenger of 5HT2-receptor stimulation in human blood platelets

1984 • 60 citations

STORAGE OF 5-HYDROXYTRYPTAMINE IN MEGAKARYOCYTES

1972 • 55 citations

Two sites of 5-hydroxytryptamine uptake in blood platelets

1967 • 53 citations

Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors.

1978 • 53 citations

SHAPE CHANGES INDUCED BY BIOLOGICALLY ACTIVE PEPTIDES AND NERVE GROWTH FACTOR IN BLOOD PLATELETS OF RABBITS

1981 • 52 citations

Specific binding sites for 5-hydroxytryptamine on rat blood platelets

1975 • 52 citations

Properties of the specific binding site for arginine vasopressin in rat hippocampal synaptic membranes.

1984 • 51 citations

Release of blood platelet serotonin by reserpine and lack of effect on bleeding time.

1956 • 50 citations

Purification and properties of a human plasma endogenous modulator for the platelet tricyclic binding/serotonin transport complex

1987 • 48 citations

Psychopharmacology: Recent Advances and Future Prospects

1986 • 48 citations

Shape change and uptake of 5-hydroxytryptamine in human blood platelets: Action of neuropsychotropic drugs

1979 • 46 citations

SHAPE CHANGE OF BLOOD PLATELETS—A MODEL FOR CEREBRAL 5‐HYDROXYTRYPTAMINE RECEPTORS?

1979 • 45 citations

Vasopressin inhibits the adenylate cyclase activity of human platelet particulate fraction through V₁‐receptors

1983 • 42 citations

Melatonin synthesis by rabbit platelets

1982 • 42 citations

Molecular aspects of the imipramine ‘receptor’

1984 • 40 citations

Storage of exogenous monoamines and reserpine in 5-hydroxytryptamine organelles of blood platelets

1969 • 38 citations

Binding of [³H]Ro 16-6491, a Reversible Inhibitor of Monoamine Oxidase Type B, to Human Brain Mitochondria and Platelet Membranes

1987 • 38 citations

Nature and properties of human platelet vasopressin receptors

1986 • 37 citations

Platelet serotonin in schizophrenia and depression.

1982 • 36 citations

Human Platelet Angiotensin II Receptors: Regulation by the Circulating Angiotensin Level*

1984 • 35 citations

Differences Between Intracellular Platelet and Brain Proteins that Bind Serotonin

1980 • 33 citations

Human platelets possess receptors for a lymphokine: demonstration of high specific receptors for HuIFN-gamma.

1987 • 33 citations

Use of a monoclonal antibody for comparative studies of monoamine oxidase B in mitochondrial extracts of human brain and peripheral tissues.

1983 • 29 citations

Dopamine uptake in platelets: Two different low-affinity, saturable mechanisms

1981 • 28 citations

Affinity chromatography of human platelet α ₂ -adrenergic receptors

1982 • 27 citations

Action of reserpine on subcellular 5-hydroxytryptamine organelles of blood platelets

1968 • 26 citations

The 5-hydroxytryptamine receptor of blood platelets

1983 • 26 citations

Mapping monoaminergic neurons with [3H]reserpine by autoradiography

1979 • 25 citations

2-Nitroimipramine: a photoaffinity probe for the serotonin uptake/tricyclic binding site complex.

1985 • 24 citations

NEURONE SPECIFIC ENOLASE (NSE) IN HUMAN BLOOD PLATELETS: IMPLICATIONS FOR THE NEURONAL MODEL

1981 • 23 citations

Platelets and biogenic amines

1984 • 23 citations

Solubilization of imipramine-binding protein from human blood platelets

1983 • 22 citations

[3H]2-nitroimipramine: A selective “slowly-dissociating” probe of the imipramine binding site (“serotonin transporter”) in platelets and brain

1983 • 21 citations

Uptake, Release, and Subcellular Localization of l‐Methyl‐4‐Phenylpyridinium in Blood Platelets

1987 • 20 citations

Platelet alpha‐adrenoceptors‐a valid model for brain or vascular adrenoceptors?

1986 • 19 citations

The Organelles Storing 5-Hydroxytryptamine in Blood Platelets

1975 • 17 citations

Coupling of H⁺ Gradients to Catecholamine Transport in Chromaffin Granules^a

1985 • 17 citations

Blood platelets as a model system for studying the biochemistry of depression.

1984 • 17 citations

Characteristics of Serotonin Uptake and Release by Platelets

1985 • 16 citations

The amine transporter from bovine chromaffin granules. Partial purification.

1985 • 16 citations

Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B

1985 • 15 citations

Rapid intracellular release of calcium in human platelets by stimulation of 5‐HT₂‐receptors

1985 • 15 citations

Activation of human blood platelets by arginine-vasopressin. Role of bivalent cations.

1985 • 15 citations

Platelet MAO concentration and molecular activity: I. New methods using an MAO B-specific monoclonal antibody in a radioimmunoassay

1986 • 14 citations

Storage of biogenic amines in intact blood platelets of man. Dependence on a proton gradient.

1982 • 13 citations

Biochemical and pharmacological characterization of histamine-mediated up-regulation of human platelet serotonin uptake. Evidence for a subclass of histamine H2 receptors (H2h) highly sensitive to H2 receptor antagonists

1986 • 12 citations

Solubilization of human platelet vasopressin receptors

1987 • 11 citations

Interaction of D-LSD with blood platelets of rabbits: shape change and specific binding.

1981 • 10 citations

Vasopressin-induced activation of human blood platelets: prominent role of Mg2+

1985 • 10 citations

The Amine Transporter from Bovine Chromaffin Granules^a

1985 • 9 citations

Some neuropharmacological effects of Ro 11-2465--a novel tricyclic antidepressant with potent inhibitory activity on the uptake of 5-HT.

1982 • 9 citations

Pharmacological characterization of dopamine sulfoconjugation by human platelets.

1987 • 9 citations

Uptake of 3H-dopamine in megakaryocytes and blood platelets measured by quantitative electron-microscope autoradiography

1986 • 9 citations

Platelet α-Granule Proteins: Biochemical and Pathological Aspects

1985 • 9 citations

Partial characterization of solubilized platelet imipramine binding sites using a new probe, [3H]3-cyanoimipramine ([3H]Ro 11-2465)

1985 • 8 citations

Platelets and biogenic amines. 2. Indications for a discrete low affinity uptake mechanism shared by norepinephrine and 5-hydroxytryptamine in human platelets

1986 • 8 citations

Ultrastructural organization of maturing megakaryocytes.

1986 • 7 citations

Blood Platelets as Models for Neurons: Similarities of the 5-Hydroxytryptamine Systems

1984 • 7 citations

Interaction of Vasopressin with Human Blood Platelets: Dependency on Mg2+

1986 • 7 citations

Frontiers in Biochemical and Pharmacological Research in Depression, Advances in Biochemical Psychopharmacology,

1986 • 6 citations

The effect of multiple rising doses of Ro 11-2465 (serotonin uptake inhibitor) on serotonin content of human platelets

1981 • 6 citations

Changes in rabbit platelet α and β adrenoceptor number and platelet aggregation

1986 • 5 citations

Uptake, metabolism and subcellular localization of MPTP and MPP+ in blood platelets.

1986 • 3 citations

PLATELET UPTAKE OF SEROTONIN IN PATHOLOGICAL CONDITIONS

1981 • 3 citations