Subunit Interface Selectivity of the α-Neurotoxins for the Nicotinic Acetylcholine Receptor

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins

1995 • 614 citations

Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein

1970 • 575 citations

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1990 • 329 citations

The Emerging Three‐Dimensional Structure of a Receptor

1996 • 197 citations

Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

1979 • 191 citations

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

1996 • 173 citations

Molecular dissection of subunit interfaces in the acetylcholine receptor: Identification of determinants of α-Conotoxin M1 selectivity

1995 • 164 citations

Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor.

1981 • 158 citations

Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis.

1993 • 153 citations

Genetic Engineering of Snake Toxins

1995 • 151 citations

Only Snake Curaremimetic Toxins with a Fifth Disulfide Bond Have High Affinity for the Neuronal α7 Nicotinic Receptor

1997 • 150 citations

Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms

1987 • 147 citations

Topology of ligand binding sites on the nicotinic acetylcholine receptor

1997 • 142 citations

Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine.

1993 • 117 citations

Binding of alpha-bungarotoxin to isolated alpha subunit of the acetylcholine receptor of Torpedo californica: quantitative analysis with protein blots.

1983 • 113 citations

Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor.

1994 • 97 citations

Molecular Dissection of Subunit Interfaces in the Acetylcholine Receptor

1996 • 92 citations

Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide.

1991 • 80 citations

Crosslinking of α‐bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

1982 • 79 citations

A model of the nicotinic receptor extracellular domain based on sequence identity and residue location

1997 • 77 citations

Identification of Pairwise Interactions in the α-Neurotoxin-Nicotinic Acetylcholine Receptor Complex through Double Mutant Cycles

1998 • 67 citations

Affinity-directed crosslinking of membrane-bound acetylcholine receptor polypeptides with photolabile .alpha.-bungarotoxin derivatives

1979 • 66 citations

The Handedness of the Subunit Arrangement of the Nicotinic Acetylcholine Receptor from Torpedo californica

1995 • 56 citations

Identification of Equivalent Residues in the γ, δ, and ε Subunits of the Nicotinic Receptor That Contribute to α-Bungarotoxin Binding

1997 • 55 citations

Nonidentity of the α-Neurotoxin Binding Sites on the Nicotinic Acetylcholine Receptor Revealed by Modification in α-Neurotoxin and Receptor Structures

1997 • 47 citations

Arrangement of the subunits of the nicotinic acetylcholine receptor of Torpedo californica as determined by .alpha.-neurotoxin crosslinking

1985 • 38 citations

Investigation of ligand binding sites of the acetylcholine receptor using photoactivatable derivatives of neurotoxin II from Naja naja oxiana

1992 • 33 citations

Topography of toxin-acetylcholine receptor complexes by using photoactivatable toxin derivatives.

1990 • 33 citations

Distinctions in Agonist and Antagonist Specificity Conferred by Anionic Residues of the Nicotinic Acetylcholine Receptor

1998 • 18 citations

Functional Effects on the Acetylcholine Receptor of Multiple Mutations of γAsp174 and δAsp180

1997 • 18 citations

Labeling of Torpedo californica nicotinic acetylcholine receptor subunits by cobratoxin derivatives with photoactivatable groups of different chemical nature at Lys23

1998 • 18 citations

Selective distinction at equilibrium between the two α‐neurotoxin binding sites of Torpedo acetylcholine receptor by microtitration

1988 • 15 citations

74Probing the structure of the ligand binding site on the muscle nicotinic receptor with Waglerin peptides

1998 • 2 citations