Hydrogen peroxide generation by mitochondria isolated from regionally ischemic and nonischemic dog myocardium

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart

1982 • 523 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Oxygen-mediated myocardial damage during ischameia and reperfusion: Role of the cellular defences against oxygen toxicity

1985 • 384 citations

A method for the simultaneous quantitative estimation of cytochromes a, b, c1, and c in mitochondria

1964 • 375 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart

1982 • 355 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow.

1987 • 246 citations

Beneficial actions of superoxide dismutase and catalase in stunned myocardium of dogs

1986 • 205 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Respiratory Activity of Isolated Rat Brain Mitochondria followingin vitroExposure to Oxygen Radicals

1983 • 181 citations

Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase**

1985 • 168 citations

Myocardial recovery during post-ischaemic reperfusion: Effects of nifedipine, calcium and magnesium

1986 • 146 citations

Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts

1986 • 139 citations

In vitro study on contribution of oxidative metabolism of isolated rabbit heart mitochondria to myocardial reperfusion injury.

1984 • 136 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Mitochondrial function, oxygen extraction, epicardial S-T segment changes and tritiated digoxin distribution after reperfusion of ischemic myocardium

1975 • 117 citations

Decreased defence against free radicals in rat heart during normal reperfusion after hypoxic, ischemic and calcium-free perfusion

1984 • 109 citations

Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia

1987 • 105 citations

A novel superoxide radical generator in heart mitochondria

1987 • 94 citations

Biochemical and morphological correlates of acute experimental myocardial ischemia in the dog. IV. Energy mechanisms during very early ischemia.

1979 • 90 citations

Effect of ischemia and reperfusion on antioxidant enzymes and mitochondrial inner membrane proteins in perfused rat heart

1988 • 85 citations

Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium

1986 • 68 citations

The effect of superoxide generation on the ability of mitochondria to take up and retain Ca²⁺

1982 • 66 citations

Myocardial dysfunction and ultrastructural alterations mediated by oxygen metabolites

1988 • 64 citations

Tissue Hypoxia and Ischemia

1977 • 64 citations

Mitochondrial hydrogen peroxide generation by NADH-oxidase activity following regional myocardial ischemia in the dog

1989 • 62 citations

Absence of detectable xanthine oxidase in human myocardium

1989 • 61 citations

Ischemia‐induced changes in myocardial paramagnetic metabolites: Implications for intracellular oxy‐radical generation

1989 • 51 citations

Glutathione peroxidase activity and release of glutathione from oxygen-deficient perfused rat heart

1979 • 44 citations

On the formation of hydrogen peroxide and oxygen radicals in heart mitochondria.

1975 • 41 citations

Clinical ischemic syndromes : mechanisms and consequences of tissue injury

1990 • 41 citations

Purine efflux after cardiac ischemia: relevance to allopurinol cardioprotection

1987 • 37 citations

Recovery time course of ventricular vulnerability after coronary reperfusion in relation to mitochondrial function in ischemic myocardium

1980 • 37 citations

Effect of superoxide generation on rat heart mitochondrial pyruvate utilization

1983 • 35 citations

Time-dependent changes in canine cardiac mitochondrial function and ultrastructure resulting from coronary occlusion and reperfusion

1980 • 32 citations

Regional differences in postischemic recovery in the stunned canine myocardium

1987 • 20 citations

Relationship between regional myocardial blood flow and mitochondrial function

1983 • 14 citations

Effect of oxygen radicals on heart mitochondrial function in alpha-tocopherol deficient rabbits.

1982 • 13 citations

Recent advances in studies on cardiac structure and metabolism. Vol. 7: Biochemistry and pharmacology of myocardial hypertrophy, hypoxia, and infarction

1977 • 3 citations