Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

1977 • 1,565 citations

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

1978 • 560 citations

Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

1979 • 348 citations

Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir

1982 • 345 citations

Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease

1975 • 337 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Induction of Both Thymidine and Deoxycytidine Kinase Activity by Herpes Viruses

1974 • 287 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

1980 • 269 citations

Mutant strains of herpes simplex deficient in thymidine kinase-inducing activity

1964 • 255 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

ISOLATION AND CHARACTERISATION OF RESISTANT HERPES SIMPLEX VIRUS AFTER ACYCLOVIR THERAPY

1982 • 239 citations

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

1980 • 229 citations

Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

1981 • 208 citations

Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase.

1984 • 196 citations

Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates

1982 • 191 citations

Biochemical Studies on the Herpes Simplex Virus-specified Deoxypyrimidine Kinase Activity

1974 • 190 citations

Pathogenicity of Acyclovir-Resistant Herpes Simplex Virus Type 1 from an Immunodeficient Child

1982 • 175 citations

Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus

1979 • 175 citations

Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion

1979 • 159 citations

Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

1980 • 152 citations

Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information

1980 • 147 citations

A colorimetric assay for the measurement of the sensitivity of herpes simplex viruses to antiviral agents

1983 • 147 citations

Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities

1981 • 146 citations

Phosphorylation of acyclovir diphosphate by cellular enzymes

1982 • 132 citations

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

1981 • 92 citations

[125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase

1977 • 91 citations

Characterization of Abnormal Thymidine Kinases Induced by Drug-resistant Strains of Herpes Simplex Virus Type 1

1983 • 91 citations

The selectivity of action of an antiherpetic agent, 9‐(2‐hydroxyethoxymethyl) guanine

1999 • 81 citations

RELATIVE POTENCIES OF ANTI‐HERPES COMPOUNDS

1977 • 76 citations

Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

1982 • 74 citations

In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine)

1980 • 61 citations

Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.

1983 • 61 citations

Phosphorylation of 5-Bromodeoxycytidine in Cells Infected with Herpes Simplex Virus

1973 • 55 citations

Acyclovir inhibition of viral DNA chain elongation in herpes simplex virus-infected cells

1982 • 50 citations

Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses

1983 • 50 citations

Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin

1983 • 49 citations

Genetic and physical evidence for the polarity of transcription of the thymidine kinase gene of herpes simplex virus

1980 • 49 citations

Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine.

1983 • 40 citations

Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir

1984 • 38 citations

Isolation of bromovinyldeoxyuridine-resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir

1982 • 32 citations

Herpes simplex virus type 2 induced pyrimidine nucleoside kinase: enzymic basis for the selective antiherpetic effect of 5-halogenated analogs of deoxycytidine

1978 • 27 citations

Properties of a novel thymidine kinase induced by an acyclovir-resistant herpes simplex virus type 1 mutant

1982 • 26 citations

Interallelic complementation of mutants of herpes simplex virus deficient in deoxypyrimidine kinase activity

1978 • 15 citations

Oral acyclovir therapy of genital herpes simplex virus type 2 infections in guinea pigs

1985 • 14 citations

Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl) guanine and Its Triphosphate

1979 • 12 citations

Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase

1983 • 1 citations