Isolation of bromovinyldeoxyuridine-resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

1978 • 560 citations

(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

1979 • 471 citations

Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir

1982 • 345 citations

Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease

1975 • 337 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Induction of Both Thymidine and Deoxycytidine Kinase Activity by Herpes Viruses

1974 • 287 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Mutant strains of herpes simplex deficient in thymidine kinase-inducing activity

1964 • 255 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

ISOLATION AND CHARACTERISATION OF RESISTANT HERPES SIMPLEX VIRUS AFTER ACYCLOVIR THERAPY

1982 • 239 citations

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

1980 • 229 citations

Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

1981 • 208 citations

Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus

1979 • 175 citations

BLOOD SUBSTITUTES

1974 • 167 citations

A virus-specific thymidine kinase in BHK21 cells infected with herpes simplex virus

1967 • 164 citations

Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion

1979 • 159 citations

Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

1980 • 152 citations

Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine in severe herpes zoster.

1980 • 130 citations

Cell-mediated Immunity in Herpes Simplex Virus-infected Mice: Induction, Characterization and Antiviral Effects of Delayed Type Hypersensitivity

1980 • 117 citations

Nucleoside analogues : chemistry, biology, and medical applications

1979 • 90 citations

Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.

1981 • 84 citations

The Sensitivity of Acyclovir-Resistant Mutants of Herpes Simplex Virus to Other Antiviral Drugs

1981 • 77 citations

Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy

1982 • 76 citations

Resistance of peripheral autonomic neurons to in vivo productive infection by herpes simplex virus mutants deficient in thymidine kinase activity

1981 • 70 citations

Effects of Oral Treatment with Acyclovir and Bromovinyldeoxyuridine on the Establishment and Maintenance of Latent Herpes Simplex Virus Infection in Mice

1981 • 56 citations

Acyclovir — A review of the preclinical and early clinical data of a new antiherpes drug

1981 • 48 citations

Antiviral chemotherapy : design of inhibitors of viral functions

1981 • 33 citations

Efficacy of E-5-(2-Bromovinyl)-2′-Deoxyuridine in the Topical Treatment of Herpetic Keratitis in Rabbits and Man

1981 • 12 citations

Strategies of drug resistance in herpes simplex

1980 • 10 citations