Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

1968 • 477 citations

Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

1979 • 348 citations

Molecular Genetics of Herpes Simplex Virus II. Mapping of the Major Viral Glycoproteins and of the Genetic Loci Specifying the Social Behavior of Infected Cells

1979 • 303 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

1980 • 229 citations

Characterization of Herpes Simplex Virus-induced Deoxyribonucleic Acid Polymerase

1973 • 210 citations

Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus

1979 • 175 citations

Herpes simplex virus resistance and sensitivity to phosphonoacetic acid

1977 • 156 citations

Identification of the herpes simplex virus DNA polymerase gene

1977 • 149 citations

Ribonucleotide Reductase Activity of Synchronized KB Cells Infected with Herpes Simplex Virus

1972 • 139 citations

DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants

1975 • 120 citations

Properties of Herpes simplex virus type 1 and type 2 DNA polymerase

1980 • 117 citations

Effects of Arabinonucleotides on Ribonucleotide Reduction by an Enzyme System from Rat Tumor

1967 • 116 citations

INHIBITION OF HERPESVIRUS DNA SYNTHESIS BY 9‐β‐D‐ARABINOFURANOSYLADENINE IN CELLULAR AND CELL‐FREE SYSTEMS *

1977 • 114 citations

Physical and genetic analysis of the herpes simplex virus DNA polymerase locus

1980 • 101 citations

Mutants of Herpes Simplex Virus Types 1 and 2 that are Resistant to Phosphonoacetic Acid Induce Altered DNA Polymerase Activities in Infected Cells

1976 • 97 citations

Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in Synchronized Suspension Cultures

1976 • 97 citations

Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells

1981 • 95 citations

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

1981 • 92 citations

Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1

1977 • 88 citations

Aranucleosides and aranucleotides in viral chemotherapy

1979 • 83 citations

Physical mapping of paar mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue

1979 • 80 citations

The Sensitivity of Acyclovir-Resistant Mutants of Herpes Simplex Virus to Other Antiviral Drugs

1981 • 77 citations

Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: Correlation of the physical and genetic maps

1980 • 75 citations

STUDIES ON THE BIOCHEMICAL BASIS FOR THE ANTIVIRAL ACTIVITIES OF SOME NUCLEOSIDE ANALOGS^*

1975 • 72 citations

In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine)

1980 • 61 citations

Recombination between temperature-sensitive mutants of herpes simplex virus type 1

1974 • 60 citations

Characteristics of Herpesvirus Mutants Resistant to Phosphonoformate and Phosphonoacetate

1979 • 54 citations

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice

1975 • 51 citations

Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus

1978 • 51 citations

Internucleotide incorporation of arabinosyladenine into herpes simplex virus and mammalian cell DNA

1981 • 45 citations

Physical mapping of temperature-sensitive mutations of herpes simplex virus type 1 by intertypic marker rescue

1978 • 42 citations

DNA covalently linked to car☐ymethyl‐cellulose and its application in affinity chromatography

1976 • 42 citations

9-β-d-Arabinofuranosyladenine as a tool to study herpes simplex virus DNA replication in vitro

1977 • 40 citations

Temperature-sensitive mutants of herpes simplex virus type 1 defective in transcriptional and post-transcriptional functions required for viral DNA synthesis

1978 • 31 citations

Differential inhibition of mammalian DNA polymerases alpha, beta and gamma and herpes simplex virus-induced DNA polymerase by the 5'-triphosphates of arabinosyladenine and arabinosylcytosine.

1978 • 9 citations

Gene expression of herpes simplex virus. III. Effect of arabinosyladenine on viral polypeptide synthesis

1981 • 7 citations

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