Exaggerated Activation of Nuclear Factor- κ B and Altered I κ B- β Processing in Cystic Fibrosis Bronchial Epithelial Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Early Pulmonary Inflammation in Infants with Cystic Fibrosis

1995 • 1,187 citations

The Role of Nuclear Factor- κ B in Cytokine Gene Regulation

1997 • 948 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.

1994 • 525 citations

Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8.

1995 • 435 citations

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

1995 • 402 citations

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.

1994 • 381 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis

1995 • 337 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.

1998 • 310 citations

A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection

1991 • 308 citations

Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy

1998 • 306 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Inhibition of TNF- α -induced NF- κ B Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132

1998 • 122 citations

Binding of Pseudomonas aeruginosa to respiratory epithelial cells from patients with various mutations in the cystic fibrosis transmembrane regulator

1995 • 105 citations

Genistein Inhibits Constitutive and Inducible NFκB Activation and Decreases IL-8 Production by Human Cystic Fibrosis Bronchial Gland Cells

1999 • 96 citations

Interleukin-8 Production by Cystic Fibrosis Nasal Epithelial Cells after Tumor Necrosis Factor- α and Respiratory Syncytial Virus Stimulation

1998 • 67 citations

Persistent Activation of RelA by Respiratory Syncytial Virus Involves Protein Kinase C, Underphosphorylated IκBβ, and Sequestration of Protein Phosphatase 2A by the Viral Phosphoprotein

1998 • 66 citations

Regulation of Human Interleukin 8 Gene Expression and Binding of Several Other Members of the Intercrine Family to Receptors for Interleukin-8

1991 • 35 citations

Control of NF-κB Activity by the IκBβ Inhibitor

1997 • 24 citations