Immunoglobulin Deficient Mice Generated by Gene Targeting as Models for Studying the Immune Response

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Malaria: Principles and Practice of Malariology

1989 • 783 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus

1978 • 528 citations

Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1989 • 505 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

The role of B cells in lpr/lpr-induced autoimmunity.

1994 • 356 citations

The Role of T _H 1 and T _H 2 Cells in a Rodent Malaria Infection

1993 • 352 citations

Studies on the capacity of B cells to serve as antigen-presenting cells.

1981 • 349 citations

Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.

1981 • 345 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

The Immune Response to Influenza Infection

1986 • 321 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; an in vitro assay of protective antibodies.

1984 • 280 citations

Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.

1986 • 261 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

Protection of Infants from Infection with Influenza A Virus by Transplacentally Acquired Antibody

1980 • 235 citations

Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice

1990 • 227 citations

Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite

1980 • 226 citations

Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor, and its enhancement by butylated hydroxyanisole.

1987 • 219 citations

The γδT Cell Receptor

1988 • 214 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humans.

1989 • 189 citations

Frequencies of CD4⁺ T cells reactive with Plasmodium chabaudi chabaudi: distinct response kinetics for cells with T_h1 and T_h2 characteristics during infection

1989 • 185 citations

Host Defenses Against Influenza Virus: The Role of Anti-Hemagglutinin Antibody

1975 • 183 citations

Malaria: Successful Immunization Against the Sexual Stages of Plasmodium gallinaceum

1976 • 182 citations

Sporozoite Vaccine Induces Genetically Restricted T Cell Elimination of Malaria from Hepatocytes

1989 • 177 citations

Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.

1992 • 175 citations

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

1992 • 174 citations

Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse

1981 • 169 citations

Natural killer cells in mouse lung: surface phenotype, target preference, and response to local influenza virus infection.

1983 • 158 citations

Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.

1981 • 153 citations

Passive immunization against murine malaria with an IgG3 monoclonal antibody.

1984 • 152 citations

T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.

1995 • 149 citations

Early B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting

1994 • 142 citations

Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans

1987 • 127 citations

Molecular studies related to the pathogenesis of cerebral malaria

1989 • 124 citations

Immunity to sporozoite-induced malaria infeciton in mice. I. The effect of immunization of T and B cell-deficient mice.

1977 • 109 citations

Adoptive protection against Plasmodium chabaudi adami malaria in athymic nude mice by a cloned T cell line.

1988 • 107 citations

Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.

1976 • 105 citations

Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes.

1982 • 105 citations

Sialic acid-dependent binding of Plasmodium falciparum merozoite surface antigen, Pf200, to human erythrocytes.

1988 • 100 citations

Antibodies to the protective antigen of Plasmodium berghei sporozoites prevent entry into cultured cells.

1982 • 98 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

Conserved Repetitive Epitope Recognized by CD4⁺Clones From a Malaria-Immunized Volunteer

1989 • 93 citations

Rapid recovery of lung histology correlates with clearance of influenza virus by specific CD8+ cytotoxic T cells.

1989 • 91 citations

Molecular studies related to the pathogenesis of cerebral malaria

1989 • 89 citations

Erythrocyte receptor recognition varies in Plasmodium falciparum isolates

1988 • 89 citations

Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase.

1993 • 84 citations

The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse.

1994 • 84 citations

Malaria immunization in Rhesus monkeys. A vaccine effective against both the sexual and asexual stages of Plasmodium knowlesi.

1978 • 83 citations

T cell abnormalities in NZB mice occur independently of autoantibody production.

1981 • 77 citations

Immunity to Sporozoite-Induced Malaria Infection in Mice

1977 • 76 citations

Immunity to Sexual Stages of Malaria Parasites

2015 • 71 citations

Immunity to Phasmodium Berghei Yoelii in Mice

1976 • 68 citations

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras.

1991 • 63 citations

Erythrocyte Receptors for Malaria Merozoites

1977 • 59 citations

Specificity and Function of T Lymphocytes Induced by Influenza A Viruses

1989 • 58 citations

Passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachea and lung of nude mice.

1988 • 56 citations

Induction of natural killer cells during murine influenza virus infection

1981 • 53 citations

Do L3T4+ T cells act as effector cells in protection against influenza virus infection.

1987 • 53 citations

Malaria: Host Responses to Infection

1989 • 52 citations

Mechanism of Immunity to Influenza: Maternal and Passive Neonatal Protection Following Immunization of Adult Ferrets with a Live Vaccinia-Influenza Virus Haemagglutinin Recombinant but Not with Recombinants Containing Other Influenza Virus Proteins

1989 • 48 citations

Proliferation of anti-DNA-producing NZB B cells in a non-autoimmune environment.

1986 • 46 citations

Plasmodium berghei: Accelerated clearance of sporozoites from blood as part of immune-mechanism in mice

1972 • 42 citations

Specific antibody-dependent cellular cytotoxicity in human malaria.

1980 • 40 citations

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

1989 • 38 citations

Erythrocyte invasion by the malarial merozoite: Recent advances

1989 • 31 citations

Anti-IgM treatment of C57BL/6-1pr/1pr mice: depletion of B cells reduces 1pr gene-induced lymphoproliferation and mononuclear cell vasculitis.

1989 • 18 citations

Immune Responses to Erythrocytic Malaria

1986 • 17 citations

A dual role for B cells in Plasmodium chabaudi chabaudi (AS) infection?

1994 • 16 citations

Enhanced response of autoantibody-secreting B cells from young mice to T-cell-derived differentiation signals

1988 • 15 citations

T cell responses in a sporozoite-immunized human volunteer and a chimpanzee

1990 • 14 citations

Malaria antigens and MHC restriction

1990 • 13 citations

Plasmodium chabaudi: Humoral and cell-mediated responses of immunized mice

1980 • 8 citations

Variation in expression of antibody-dependent cell-mediated cytotoxicity in rodents with malaria

1988 • 6 citations