Effects of the Kappa-opioid Receptor Agonist, U69593, on the Development of Sensitization and on the Maintenance of Cocaine Self-administration

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Factors That Predict Individual Vulnerability to Amphetamine Self-Administration

1989 • 1,354 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration

1990 • 574 citations

The basolateral amygdala-ventral striatal system and conditioned place preference: Further evidence of limbic-striatal interactions underlying reward-related processes

1991 • 507 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Limbic-striatal interactions in reward-related processes

1989 • 463 citations

[3H]U-69593 a highly selective ligand for the opioid κ receptor

1985 • 439 citations

Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.

1993 • 369 citations

Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine

1992 • 347 citations

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine

1997 • 338 citations

Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.

1996 • 301 citations

Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.

1994 • 299 citations

Differential effects of excitotoxic lesions of the basolateral amygdala, ventral subiculum and medial prefrontal cortex on responding with conditioned reinforcement and locomotor activity potentiated by intra-accumbens infusions ofd-amphetamine

1993 • 296 citations

Preexposure sensitizes rats to the rewarding effects of cocaine

1990 • 273 citations

Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics.

1995 • 263 citations

Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine

1998 • 249 citations

Kappa opioid inhibition of morphine and cocaine self-administration in rats

1995 • 238 citations

U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking

1999 • 194 citations

Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine.

1996 • 162 citations

Effects of kappa opioids on cocaine self-administration by rhesus monkeys.

1997 • 161 citations

The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat

1993 • 152 citations

kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine.

1996 • 151 citations

Supersensitivity to the reinforcing effects of cocaine following 6-hydroxydopamine lesions to the medial prefrontal cortex in rats

1991 • 144 citations

Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization

1999 • 143 citations

Differential effects of excitotoxic lesions of the amygdala on cocaine-induced conditioned locomotion and conditioned place preference

1993 • 136 citations

Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors

1993 • 135 citations

Effects of kappa opioid agonists on cocaine- and food-maintained responding by rhesus monkeys.

1998 • 132 citations

The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity

1995 • 129 citations

Enhanced dopamine efflux in the amygdala by a predictive, but not a non-predictive, stimulus: facilitation by prior repeated d-amphetamine

1999 • 128 citations

Modulation of the discriminative stimulus effects of cocaine by mu and kappa opioids.

1992 • 113 citations

Caffeine exposure sensitizes rats to the reinforcing effects of cocaine

1991 • 111 citations

Parallel processing strategies in the application of microcomputers to the behavioral laboratory

1985 • 107 citations

Cocaine self-administration increased by compounding discriminative stimuli

1996 • 97 citations

Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists.

1995 • 89 citations

Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the κ-opioid receptor agonist U69593

1998 • 85 citations

Enhancement of drug-seeking behavior by environmental stimuli associated with cocaine or morphine injections

1979 • 76 citations

Opioid modulation of the discriminative stimulus effects of cocaine

1994 • 69 citations

Sensitization to Cocaine's Reinforcing Effects Produced by Various Cocaine Pretreatment Regimens in Rats

2000 • 67 citations

Enhanced acquisition of discriminative approach following intra-amygdala d -amphetamine

1997 • 56 citations

Initiation, maintenance and extinction of cocaine self-administration with and without conditioned reward

1996 • 52 citations

Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective ?-opioid receptor agonist

1998 • 48 citations

Behavioral Effects of Psychomotor Stimulant Infusions into Amygdaloid Nuclei

1999 • 40 citations

Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective κ‐opioid receptor agonist

1998 • 1 citations

Deleted Work

1955 • 0 citations