Stimulated renal tubular epithelial cells induce anergy in CD4+ T cells

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.

1989 • 451 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis.

1988 • 311 citations

INCREASED MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION IN UNILATERAL ISCHEMIC ACUTE TUBULAR NECROSIS IN THE MOUSE

1990 • 260 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

1990 • 246 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis.

1990 • 199 citations

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNFα

1991 • 151 citations

The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones.

1983 • 141 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

In vitro and in vivo interleukin-8 production in human renal cortical epithelia

1992 • 138 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Expression of leucocyte and lymphocyte adhesion molecules in the human kidney

1989 • 126 citations

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.

1990 • 109 citations

Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis.

1989 • 100 citations

Processing and presentation of self and foreign antigens by the renal proximal tubule.

1992 • 99 citations

Induction of IA antigens in murine renal transplants.

1985 • 84 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

EXPRESSION OF HLA ANTIGENS ON RENAL TUBULAR CELLS IN CULTURE II. EFFECT OF INCREASED HLA ANTIGEN EXPRESSION ON TUBULAR CELL STIMULATION OF LYMPHOCYTE ACTIVATION AND ON THEIR VULNERABILITY TO CELL-MEDIATED LYSIS

1988 • 71 citations

EXPRESSION OF HLA ANTIGENS ON RENAL TUBULAR CELLS IN CULTURE

1986 • 61 citations

Expression of HLA-DQ, -DR, and -DP antigens in normal kidney and glomerulonephritis

1989 • 58 citations

REGULATION OF CYTOKINE-STIMULATED VASCULAR CELL ADHESION MOLECULE-1 EXPRESSION IN RENAL TUBULAR EPITHELIAL CELLS

1993 • 35 citations

Inappropriate major histocompatibility complex class II expression by thyroid follicular cells in thyroid autoimmune disease and by pancreatic beta cells in type I diabetes.

1986 • 30 citations

Graft-vs-host reactions induce H-2 class II gene transcription in host kidney cells

1984 • 29 citations