Chapter 18 Model cell lines for the study of apoptosis in vitro

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

1977 • 2,070 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Culturing nerve cells

1998 • 1,304 citations

Cell biology :a laboratory handbook.

1994 • 1,213 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Plasticity of the Differentiated State

1985 • 839 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Chapter 9 The End of the (Cell) Line: Methods for the Study of Apoptosis in Vitro

1995 • 569 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.

1980 • 436 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments

2000 • 311 citations

Regulated Commitment of TNF Receptor Signaling

1999 • 282 citations

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

1998 • 254 citations

Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems

1999 • 251 citations

Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.

1991 • 247 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells

1994 • 215 citations

Insulin-like Growth Factor-II Is an Autocrine Survival Factor for Differentiating Myoblasts

1996 • 205 citations

Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.

1985 • 203 citations

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1998 • 202 citations

Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1978 • 200 citations

CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults

1999 • 192 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels.

1999 • 160 citations

Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens

1994 • 150 citations

Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines

1998 • 140 citations

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

1999 • 138 citations

Inositol 1,4,5-Trisphosphate Receptor Type 1 Is a Substrate for Caspase-3 and Is Cleaved during Apoptosis in a Caspase-3-dependent Manner

1999 • 130 citations

Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media.

1993 • 120 citations

Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

1999 • 120 citations

A Role for the Putative Tumor Suppressor Bin1 in Muscle Cell Differentiation

1998 • 116 citations

Differentiation of cultured human breast cancer cells (AU‐565 and MCF‐7) associated with loss of cell surface HER‐2/neu antigen

1990 • 115 citations

Common Regulation of Apoptosis Signaling Induced by CD95 and the DNA-damaging Stimuli Etoposide and γ-Radiation Downstream from Caspase-8 Activation

1999 • 114 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.

1995 • 107 citations

Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells

1998 • 105 citations

Use of I region-restricted, antigen-specific T cell hybridomas to produce idiotypically specific anti-receptor antibodies.

1983 • 102 citations

Ceramide induces apoptosis in PC12 cells

1997 • 101 citations

Bcl-2 Expression Identifies an Early Stage of Myogenesis and Promotes Clonal Expansion of Muscle Cells

1998 • 96 citations

Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.

1988 • 94 citations

Multiple Pathways of Apoptosis in PC12 Cells

1999 • 93 citations

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2

1998 • 89 citations

Inhibition of Nuclear Factor-κB-mediated Transcription by Association with the Amino-terminal Enhancer of Split, a Groucho-related Protein Lacking WD40 Repeats

2000 • 88 citations

Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells

1999 • 84 citations

Efficient Transfection and Expression of Heterologous Genes in PC12 Cells

1990 • 78 citations

Extracellular HIV‐1 Tat protein activates phosphatidylinositol 3‐ and Akt/PKB kinases in CD4⁺ T lymphoblastoid Jurkat cells

1997 • 77 citations

Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes

1996 • 73 citations

Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model

1998 • 68 citations

Secretion and Transcriptional Regulation of Transforming Growth Factor-β3 during Myogenesis

1991 • 67 citations

p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells

1999 • 61 citations

Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression

1994 • 60 citations

Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines

2000 • 59 citations

Protein Tyrosine Kinase p56 Is Required for Ceramide-induced but Not Tumor Necrosis Factor-induced Activation of NF-κB, AP-1, JNK, and Apoptosis

2000 • 56 citations

Direct evidence that ERK regulates the production/secretion of interleukin‐2 in PHA/PMA‐stimulated T lymphocytes

1999 • 55 citations

Neuron-restrictive silencer elements mediate neuron specificity of adenoviral gene expression

1999 • 52 citations

T cell triggering by lectins I. Requirements for interleukin 2 production;er lectin concentration determines the accessory cell dependency

1985 • 50 citations

Transfected MCF-7 cells as a model for breast cancer progression

1994 • 49 citations

Regulation of BAX and BCL‐2 expression in breast cancer cells by chemotherapy

1999 • 47 citations

Cyclin D3 Regulates Proliferation and Apoptosis of Leukemic T Cell Lines

1999 • 47 citations

Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.

1991 • 46 citations

Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation

1999 • 42 citations

A protease-dependent TCR-induced death pathway in mature lymphocytes.

1995 • 41 citations

A recombinant adenovirus expressing wild type p53 induces apoptosis in drug-resistant human breast cancer cells: a gene therapy approach for drug-resistant cancers.

1997 • 41 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system

1995 • 33 citations

A simple assay for examining the effect of transiently expressed genes on programmed cell death

1995 • 32 citations

Insulin-like Growth Factor-1 Inhibits Cell Death Induced by Anticancer Drugs in the MCF-7 Cells: Involvement of Growth Factors in Drug Resistance

1995 • 32 citations

Histone-mediated transfer and expression of the HIV-1 tat gene in Jurkat cells.

1999 • 28 citations

Requirement for Shc in TCR-mediated activation of a T cell hybridoma.

1999 • 26 citations

Adenovirus-Mediated Transfer of Bcl-XL Protects Neuronal Cells from Bax-Induced Apoptosis

2000 • 25 citations

Bcl-xL inhibits different apoptotic pathways in rat PC12 cells

1998 • 24 citations

Chapter 11 Use of Cultured Neurons and Neuronal Cell Lines to Study Morphological, Biochemical, and Molecular Changes Occurring in Cell Death

1995 • 23 citations

Effects of Differential Overexpression of Bcl-2 on Apoptosis, Proliferation, and Telomerase Activity in Jurkat T Cells

1999 • 23 citations

Chapter 27 Cytokines and cytokine-related substances regulating glial cell response to injury of the central nervous system

1994 • 22 citations

A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).

1983 • 21 citations

T Cell Receptor-induced Activation and Apoptosis In Cycling Human T Cells Occur throughout the Cell Cycle

1999 • 20 citations

Application of fluorescence microscopy to measure apoptosis in Jurkat T cells after treatment with a new investigational anticancer agent (N.C.1213).

1998 • 18 citations

Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin–cholesterol acyltransferase

1999 • 16 citations

Human breast adenocarcinoma MCF-7/0 cells electroporated with cytosolic class 3 aldehyde dehydrogenases obtained from tumor cells and a normal tissue exhibit differential sensitivity to mafosfamide.

1995 • 14 citations

Polyamine profiles and growth properties of ornithine decarboxylase overexpressing MCF-7 breast cancer cells in culture

1995 • 14 citations

Actin Cytoskeleton as a Target for 2-Chloro Adenosine: Evidence for Induction of Apoptosis in C2C12 Myoblastic Cells

1997 • 14 citations

Estradiol enhances gene delivery to human breast tumor cells

1998 • 13 citations

Protein phosphatase 1 isoforms in differentiating C2C12 myocytes

1998 • 8 citations

Preface

1995 • 6 citations

Retroviral transfer of the ?-nerve growth factor gene into murine neuroectodermal tumor cells modulates cell proliferation rate, neurite formation, and NGF binding site expression

2000 • 5 citations

A single amino acid substitution in a cytochrome c T cell stimulatory peptide changes the MHC restriction element from one isotype (I-Ak) to another (I-Ek)

1993 • 2 citations