Complementary Roles for Rpn11 and Ubp6 in Deubiquitination and Proteolysis by the Proteasome

Functional organization of the yeast proteome by systematic analysis of protein complexes

2002 • 4,751 citations

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26 S Proteasome

2002 • 983 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

A cryptic protease couples deubiquitination and degradation by the proteasome

2002 • 720 citations

The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage

2003 • 718 citations

Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

2002 • 680 citations

Multiple Associated Proteins Regulate Proteasome Structure and Function

2002 • 633 citations

Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

2002 • 599 citations

Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

2000 • 574 citations

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

2000 • 560 citations

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

2001 • 495 citations

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

1998 • 487 citations

Proteasome subunit Rpn1 binds ubiquitin-like protein domains

2002 • 457 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

2002 • 445 citations

Current Protocols in Protein Science

2001 • 443 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

Endoproteolytic Activity of the Proteasome

2003 • 425 citations

The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

1996 • 393 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

When ubiquitin meets ubiquitin receptors: a signalling connection

2003 • 303 citations

Rad23 Promotes the Targeting of Proteolytic Substrates to the Proteasome

2002 • 293 citations

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein

1998 • 281 citations

Structural basis for the specificity of ubiquitin C-terminal hydrolases

1999 • 279 citations

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

2000 • 273 citations

Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates

1985 • 263 citations

Ubiquitin as a degradation signal.

1992 • 261 citations

Otubains: a new family of cysteine proteases in the ubiquitin pathway

2003 • 258 citations

Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome

2001 • 251 citations

ATP Hydrolysis by the Proteasome Regulatory Complex PAN Serves Multiple Functions in Protein Degradation

2003 • 248 citations

Rad23 Ubiquitin-associated Domains (UBA) Inhibit 26 S Proteasome-catalyzed Proteolysis by Sequestering Lysine 48-linked Polyubiquitin Chains

2003 • 244 citations

Proteins Are Unfolded on the Surface of the ATPase Ring before Transport into the Proteasome

2001 • 235 citations

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

2003 • 216 citations

MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function.

2002 • 211 citations

NEDP1, a Highly Conserved Cysteine Protease That deNEDDylates Cullins

2003 • 192 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

Identification and Characterization of DEN1, a Deneddylase of the ULP Family

2003 • 189 citations

Deubiquitinating enzymes—the importance of driving in reverse along the ubiquitin–proteasome pathway

2003 • 189 citations

Proteasome Disassembly and Downregulation Is Correlated with Viability during Stationary Phase

2003 • 172 citations

A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.

1992 • 161 citations

A Novel Type of Deubiquitinating Enzyme

2003 • 161 citations

Deubiquitinating Enzymes as Cellular Regulators

2003 • 160 citations

Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics

2003 • 154 citations

The Regulatory Complex of Drosophila melanogaster 26s Proteasomes

2000 • 145 citations

Identification of ubiquitin-like protein-binding subunits of the 26S proteasome

2002 • 138 citations

Interaction of the Doa4 Deubiquitinating Enzyme with the Yeast 26S Proteasome

1999 • 126 citations

Structure of the Jab1/MPN Domain and Its Implications for Proteasome Function

2003 • 125 citations

Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex.

1993 • 125 citations

Specificity of the Ubiquitin Isopeptidase in the PA700 Regulatory Complex of 26 S Proteasomes

1997 • 111 citations

Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.

1986 • 102 citations

Dis-assembly lines: the proteasome and related ATPase-assisted proteases

2000 • 95 citations

Getting in and out of the proteasome

2000 • 76 citations

Ubiquitin-mediated degradation of histone H3 does not require the substrate-binding ubiquitin protein ligase, E3, or attachment of polyubiquitin chains.

1990 • 75 citations

A Mutation in a Novel Yeast Proteasomal Gene,RPN11/MPR1, Produces a Cell Cycle Arrest, Overreplication of Nuclear and Mitochondrial DNA, and an Altered Mitochondrial Morphology

1998 • 74 citations

Conservation of the COP9/signalosome in budding yeast.

2002 • 73 citations

Interaction of the Anaphase-promoting Complex/Cyclosome and Proteasome Protein Complexes with Multiubiquitin Chain-binding Proteins

2003 • 67 citations

COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae

2002 • 67 citations

Use of RNA Interference and Complementation To Study the Function of the Drosophila and Human 26S Proteasome Subunit S13

2003 • 65 citations

Identification of a 26S Proteasome-Associated UCH in Fission Yeast

2000 • 63 citations

Functional receptors for vasoactive intestinal peptide in cultured vascular smooth muscle cells from rat aorta

1985 • 61 citations

Conjugation and deconjugation of ubiquitin regulating the destiny of proteins

2003 • 60 citations

The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes

2003 • 58 citations

Ubiquitin binding proteins protect ubiquitin conjugates from disassembly

2002 • 53 citations

Degradation of Monoubiquitinated .alpha.-Globin by 26S Proteasomes

1995 • 52 citations

Rub1p Processing by Yuh1p Is Required for Wild-Type Levels of Rub1p Conjugation to Cdc53p

2002 • 46 citations

Chemically Synthesized Ubiquitin Extension Proteins Detect Distinct Catalytic Capacities of Deubiquitinating Enzymes

1999 • 36 citations

Differential Effects of Ubiquitin Aldehyde on Ubiquitin and ATP-Dependent Protein Degradation

1996 • 32 citations

Regulating the 26S Proteasome

2002 • 30 citations

Mitochondrial effects of the pleiotropic proteasomal mutation mpr1/rpn11 : uncoupling from cell cycle defects in extragenic revertants

2002 • 25 citations

Ubiquitin System: JAMMing in the Name of the Lid

2002 • 22 citations

A method for assaying deubiquitinating enzymes

1998 • 10 citations