Cognitive and emotional control of pain and its disruption in chronic pain
Data up to Jan 2025
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Abstract
References (183)
Control of goal-directed and stimulus-driven attention in the brain
2002 • 11,810 citations
SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION
1937 • 3,950 citations
Emotion, Decision Making and the Orbitofrontal Cortex
2000 • 3,415 citations
N‐back working memory paradigm: A meta‐analysis of normative functional neuroimaging studies
2005 • 3,237 citations
Human brain mechanisms of pain perception and regulation in health and disease
2005 • 2,917 citations
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
1984 • 2,580 citations
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
1997 • 2,540 citations
Neural consequences of enviromental enrichment
2000 • 2,376 citations
On the relationship between emotion and cognition
2008 • 2,034 citations
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
2004 • 1,961 citations
Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain
2010 • 1,870 citations
The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.
2000 • 1,784 citations
Mindfulness practice leads to increases in regional brain gray matter density
2010 • 1,651 citations
Meditation experience is associated with increased cortical thickness
2005 • 1,607 citations
Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density
2004 • 1,330 citations
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
2002 • 1,228 citations
Endogenous pain control mechanisms: Review and hypothesis
1978 • 1,217 citations
Psychosomatic Disease and the "Visceral Brain"
1949 • 1,163 citations
Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe
1989 • 1,146 citations
Dissociating Pain from Its Anticipation in the Human Brain
1999 • 1,142 citations
Central modulation of pain
2010 • 997 citations
Chronic pain and medullary descending facilitation
2002 • 968 citations
The effect of pain on cognitive function: A review of clinical and preclinical research
2011 • 949 citations
Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems
1999 • 863 citations
Imaging how attention modulates pain in humans using functional MRI
2002 • 858 citations
Control over brain activation and pain learned by using real-time functional MRI
2005 • 847 citations
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
2001 • 832 citations
Social Modulation of Pain as Evidence for Empathy in Mice
2006 • 825 citations
Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections
1989 • 802 citations
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
2009 • 789 citations
The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
2011 • 737 citations
Neurobiological Mechanisms of the Placebo Effect
2005 • 733 citations
Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain
2006 • 716 citations
Pain perception: Is there a role for primary somatosensory cortex?
1999 • 699 citations
Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—an fMRI analysis
2004 • 673 citations
Cognitive modulation of pain: how do attention and emotion influence pain processing?
2002 • 667 citations
Significance of the insula for the evolution of human awareness of feelings from the body
2011 • 595 citations
Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation
2011 • 590 citations
Pain “Relief” by Frontal Cingulumotomy
1962 • 573 citations
Imaging Attentional Modulation of Pain in the Periaqueductal Gray in Humans
2002 • 561 citations
Effective Treatment of Chronic Low Back Pain in Humans Reverses Abnormal Brain Anatomy and Function
2011 • 560 citations
Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation
2002 • 539 citations
Placebo effects on human μ-opioid activity during pain
2007 • 535 citations
Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch
1986 • 531 citations
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
2000 • 524 citations
Investigation of mindfulness meditation practitioners with voxel-based morphometry
2007 • 521 citations
Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain
2010 • 508 citations
Chronic pain patients are impaired on an emotional decision-making task
2004 • 504 citations
Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain
2009 • 493 citations
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
2007 • 491 citations
Reward Circuitry Activation by Noxious Thermal Stimuli
2001 • 490 citations
Conditioned Pain Modulation in Populations With Chronic Pain: A Systematic Review and Meta-Analysis
2012 • 487 citations
The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions
2008 • 484 citations
Does Anticipation of Pain Affect Cortical Nociceptive Systems?
2002 • 464 citations
Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli
2003 • 445 citations
Asymbolia for pain: A sensory‐limbic disconnection syndrome
1988 • 435 citations
The underlying anatomical correlates of long-term meditation: Larger hippocampal and frontal volumes of gray matter
2009 • 435 citations
Pain-related cerebral activation is altered by a distracting cognitive task
2000 • 424 citations
The whole body receptive field of dorsal horn multireceptive neurones
2002 • 418 citations
PAIN IN MEN WOUNDED IN BATTLE
1946 • 416 citations
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients
2009 • 409 citations
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
2002 • 399 citations
Region-specific encoding of sensory and affective components of pain in the human brain: A positron emission tomography correlation analysis
1999 • 396 citations
Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients
2006 • 395 citations
Fibromyalgia patients show an abnormal dopamine response to pain
2007 • 391 citations
Cortical thickness and pain sensitivity in zen meditators.
2010 • 385 citations
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
2009 • 381 citations
Mood Influences Supraspinal Pain Processing Separately from Attention
2009 • 364 citations
Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation
2010 • 360 citations
Age effects on gray matter volume and attentional performance in Zen meditation
2007 • 357 citations
Responses of primate SI cortical neurons to noxious stimuli
1983 • 351 citations
The Spinothalamic System Targets Motor and Sensory Areas in the Cerebral Cortex of Monkeys
2009 • 343 citations
Effects of odors on pain perception: deciphering the roles of emotion and attention
2003 • 342 citations
Central Mechanisms of Pain Revealed Through Functional and Structural MRI
2012 • 340 citations
Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex
2008 • 339 citations
Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain
2009 • 339 citations
Cerebral Activation in Patients With Irritable Bowel Syndrome and Control Subjects During Rectosigmoid Stimulation
2001 • 332 citations
Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms
2005 • 331 citations
Elevated insular glutamate in fibromyalgia is associated with experimental pain
2009 • 296 citations
Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study
2000 • 294 citations
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: A longitudinal voxel‐based morphometric study
2010 • 290 citations
Pain sensitivity alterations as a function of lesion location in the parasylvian cortex
1999 • 287 citations
Regular Exercise Reverses Sensory Hypersensitivity in a Rat Neuropathic Pain Model
2011 • 282 citations
A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators
2010 • 280 citations
Induction of Depressed Mood Disrupts Emotion Regulation Neurocircuitry and Enhances Pain Unpleasantness
2010 • 270 citations
Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala
2005 • 262 citations
A Comparison of Visceral and Somatic Pain Processing in the Human Brainstem Using Functional Magnetic Resonance Imaging
2005 • 262 citations
White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion‐tensor and volumetric imaging study
2008 • 262 citations
Variability of laser-evoked potentials: attention, arousal and lateralized differences
1993 • 260 citations
Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain
2012 • 256 citations
Brain–computer interface using fMRI: spatial navigation by thoughts
2004 • 252 citations
MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain
2009 • 250 citations
Cerebral and spinal modulation of pain by emotions
2009 • 248 citations
Pain Attenuation through Mindfulness is Associated with Decreased Cognitive Control and Increased Sensory Processing in the Brain
2011 • 247 citations
Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura
2006 • 245 citations
Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study
1999 • 238 citations
Pain affect without pain sensation in a patient with a postcentral lesion
1999 • 237 citations
Parsing Pain Perception Between Nociceptive Representation and Magnitude Estimation
2008 • 234 citations
Love hurts: An fMRI study
2010 • 232 citations
Reduced Brainstem Inhibition during Anticipated Pelvic Visceral Pain Correlates with Enhanced Brain Response to the Visceral Stimulus in Women with Irritable Bowel Syndrome
2008 • 232 citations
Emotional valence contributes to music-induced analgesia
2007 • 231 citations
Anticipatory brainstem activity predicts neural processing of pain in humans
2006 • 227 citations
Chapter 14 Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain
1996 • 226 citations
SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation
1988 • 222 citations
Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgeia
2012 • 207 citations
Distraction Modulates Anterior Cingulate Gyrus Activations during the Cold Pressor Test
2001 • 207 citations
Pain imaging in health and disease — how far have we come?
2010 • 204 citations
Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators
2012 • 203 citations
The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation
2003 • 199 citations
Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia
2008 • 192 citations
Histochemical and immunocytochemical compartments of the thalamic VPM nucleus in monkeys and their relationship to the representational map
1991 • 190 citations
Alteration of cortical excitability in patients with fibromyalgia
2010 • 189 citations
Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury
2009 • 187 citations
Empathy hurts: Compassion for another increases both sensory and affective components of pain perception
2007 • 185 citations
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome
2005 • 183 citations
Treating pain with pain: Supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
2011 • 176 citations
Patients With Irritable Bowel Syndrome Have Altered Emotional Modulation of Neural Responses to Visceral Stimuli
2010 • 175 citations
Executive Function and Decision-Making in Women with Fibromyalgia
2009 • 174 citations
Gray matter changes related to chronic posttraumatic headache
2009 • 167 citations
Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval
1990 • 167 citations
Disruption of cognitive function in Fibromyalgia Syndrome ☆
2008 • 161 citations
CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
1994 • 160 citations
Differential brain opioid receptor availability in central and peripheral neuropathic pain
2006 • 160 citations
Modulation of pain processing in hyperalgesia by cognitive demand
2005 • 159 citations
Efficacy and effectiveness of cognitive behaviour therapy for chronic pain: Progress and some challenges
2010 • 156 citations
Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET
2004 • 151 citations
The cerebellum: organization, functions and its role in nociception
2003 • 150 citations
Cerebral Responses to Noxious Thermal Stimulation in Chronic Low Back Pain Patients and Normal Controls
2002 • 136 citations
White matter brain and trigeminal nerve abnormalities in temporomandibular disorder
2012 • 134 citations
Distraction as a key determinant of impaired memory in patients with fibromyalgia.
2006 • 130 citations
Experience-dependent plasticity in white matter microstructure: reasoning training alters structural connectivity
2012 • 128 citations
The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats
2009 • 127 citations
Assessment of the Effects of Aquatic Therapy on Global Symptomatology in Patients With Fibromyalgia Syndrome: A Randomized Controlled Trial
2008 • 119 citations
The role of rostral cingulumotomy in "pain" relief.
1968 • 109 citations
Novel Evidence for Hypersensitivity of Visceral Sensory Neural Circuitry in Irritable Bowel Syndrome Patients
2006 • 109 citations
Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study
2001 • 109 citations
Multiple white matter tract abnormalities underlie cognitive impairment in RRMS
2011 • 107 citations
Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain
2009 • 106 citations
Altered associative learning and emotional decision making in fibromyalgia
2010 • 104 citations
Flexible Cerebral Connectivity Patterns Subserve Contextual Modulations of Pain
2010 • 103 citations
Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain
2006 • 103 citations
Distraction and Placebo
2012 • 99 citations
White matter microstructural alterations in migraine: A diffusion-weighted MRI study
2012 • 98 citations
Bridging the hemispheres in meditation: Thicker callosal regions and enhanced fractional anisotropy (FA) in long-term practitioners
2012 • 94 citations
Experimentally Induced Mood Changes Preferentially Affect Pain Unpleasantness
2008 • 94 citations
Brain chemistry reflects dual states of pain and anxiety in chronic low back pain
2002 • 93 citations
Chronic pain‐induced emotional dysfunction is associated with astrogliosis due to cortical δ‐opioid receptor dysfunction
2006 • 92 citations
Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts
2008 • 92 citations
Long‐term potentiation of neuronal excitation by neuron–glia interactions in the rat spinal dorsal horn
2007 • 85 citations
Altered processing of pain‐related information in patients with fibromyalgia
2004 • 85 citations
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory
2010 • 84 citations
Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems
2009 • 76 citations
Olfactory dysfunction, gambling task performance and intracranial lesions after traumatic brain injury.
2010 • 73 citations
1H-MR spectroscopic detection of metabolic changes in pain processing brain regions in the presence of non-specific chronic low back pain
2010 • 73 citations
The modulation of pain by attention and emotion: A dissociation of perceptual and spinal nociceptive processes
2011 • 70 citations
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls
2007 • 70 citations
Attentional modulation of visceral and somatic pain
2007 • 70 citations
Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study.
2011 • 67 citations
Alterations in attentional mechanisms in response to acute inflammatory pain and morphine administration
2007 • 62 citations
Diffusion-Weighted and Diffusion Tensor Imaging in Fibromyalgia Patients: A Prospective Study of Whole Brain Diffusivity, Apparent Diffusion Coefficient, and Fraction Anisotropy in Different Regions of the Brain and Correlation With Symptom Severity
2007 • 61 citations
Fibromyalgia unique temporal brain activation during experimental pain: a controlled fMRI Study
2009 • 58 citations
Enriched environment and the recovery from inflammatory pain: Social versus physical aspects and their interaction
2009 • 57 citations
The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain
2012 • 52 citations
Thermoreceptive lamina I trigeminothalamic neurons project to the nucleus submedius in the cat
1991 • 52 citations
Differential SPECT Activation Patterns Associated with PASAT Performance May Indicate Frontocerebellar Functional Dissociation in Chronic Mild Traumatic Brain Injury
2009 • 48 citations
Nerve injury causes long-term attentional deficits in rats
2012 • 48 citations
Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in rats
2008 • 45 citations
Dynamic assessment of the right lateral frontal cortex response to painful stimulation
2010 • 44 citations
Behavioral and Neuronal Investigations of Hypervigilance in Patients with Fibromyalgia Syndrome
2012 • 43 citations
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
2007 • 38 citations
The opioid placebo analgesia is mediated exclusively through µ-opioid receptor in rat
2012 • 38 citations
Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running
2006 • 37 citations
Subjective estimates of chronic pain before and after psychosurgery or treatment in a pain unit
1981 • 37 citations
Pain Mechanisms and Management
1997 • 36 citations
The lateral ventromedial thalamic nucleus spreads nociceptive signals from the whole body surface to layer I of the frontal cortex
2005 • 34 citations
Proprioceptive pathways to posterior parietal areas MIP and LIPv from the dorsal column nuclei and the postcentral somatosensory cortex
2011 • 33 citations
Neurophysiological processes underlying the phantom limb pain experience and the use of hypnosis in its clinical management: An intensive examination of two patients
2001 • 30 citations
Mild head injury and sympathetic arousal: Investigating relationships with decision-making and neuropsychological performance in university students
2011 • 29 citations
Environmental housing affects the duration of mechanical allodynia and the spinal astroglial activation in a rat model of chronic inflammatory pain
2009 • 22 citations
Attentional modulation fails to attenuate the subjective pain experience in chronic, unexplained pain
2009 • 20 citations
Preoperative housing in an enriched environment significantly reduces the duration of post-operative pain in a rat model of knee inflammation
2009 • 17 citations
Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice
2009 • 13 citations
Environmental enrichment reduces mechanical hypersensitivity in neuropathic mice, but fails to abolish the phenotype of CCK2 receptor deficient mice
2009 • 6 citations