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Cognitive and emotional control of pain and its disruption in chronic pain

Data up to Jan 2025

Published2013
Citations1,663
References183

Total Citations Per Year

Abstract

References (183)

Control of goal-directed and stimulus-driven attention in the brain

2002 • 11,810 citations

SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION

1937 • 3,950 citations

Emotion, Decision Making and the Orbitofrontal Cortex

2000 • 3,415 citations

N‐back working memory paradigm: A meta‐analysis of normative functional neuroimaging studies

2005 • 3,237 citations

Human brain mechanisms of pain perception and regulation in health and disease

2005 • 2,917 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex

1997 • 2,540 citations

Neural consequences of enviromental enrichment

2000 • 2,376 citations

On the relationship between emotion and cognition

2008 • 2,034 citations

Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain

2004 • 1,961 citations

Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain

2010 • 1,870 citations

The neurobiology of stress: from serendipity to clinical relevance11Published on the World Wide Web on 22 November 2000.

2000 • 1,784 citations

Mindfulness practice leads to increases in regional brain gray matter density

2010 • 1,651 citations

Meditation experience is associated with increased cortical thickness

2005 • 1,607 citations

Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density

2004 • 1,330 citations

Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia

2002 • 1,228 citations

Endogenous pain control mechanisms: Review and hypothesis

1978 • 1,217 citations

Psychosomatic Disease and the "Visceral Brain"

1949 • 1,163 citations

Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe

1989 • 1,146 citations

Dissociating Pain from Its Anticipation in the Human Brain

1999 • 1,142 citations

Central modulation of pain

2010 • 997 citations

Chronic pain and medullary descending facilitation

2002 • 968 citations

The effect of pain on cognitive function: A review of clinical and preclinical research

2011 • 949 citations

Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems

1999 • 863 citations

Imaging how attention modulates pain in humans using functional MRI

2002 • 858 citations

Control over brain activation and pain learned by using real-time functional MRI

2005 • 847 citations

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

2001 • 832 citations

Social Modulation of Pain as Evidence for Empathy in Mice

2006 • 825 citations

Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections

1989 • 802 citations

Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia

2009 • 789 citations

The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil

2011 • 737 citations

Neurobiological Mechanisms of the Placebo Effect

2005 • 733 citations

Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain

2006 • 716 citations

Pain perception: Is there a role for primary somatosensory cortex?

1999 • 699 citations

Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—an fMRI analysis

2004 • 673 citations

Cognitive modulation of pain: how do attention and emotion influence pain processing?

2002 • 667 citations

Significance of the insula for the evolution of human awareness of feelings from the body

2011 • 595 citations

Brain Mechanisms Supporting the Modulation of Pain by Mindfulness Meditation

2011 • 590 citations

Pain “Relief” by Frontal Cingulumotomy

1962 • 573 citations

Imaging Attentional Modulation of Pain in the Periaqueductal Gray in Humans

2002 • 561 citations

Effective Treatment of Chronic Low Back Pain in Humans Reverses Abnormal Brain Anatomy and Function

2011 • 560 citations

Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation

2002 • 539 citations

Placebo effects on human μ-opioid activity during pain

2007 • 535 citations

Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch

1986 • 531 citations

Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study

2000 • 524 citations

Investigation of mindfulness meditation practitioners with voxel-based morphometry

2007 • 521 citations

Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain

2010 • 508 citations

Chronic pain patients are impaired on an emotional decision-making task

2004 • 504 citations

Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain

2009 • 493 citations

Decreased Central μ-Opioid Receptor Availability in Fibromyalgia

2007 • 491 citations

Reward Circuitry Activation by Noxious Thermal Stimuli

2001 • 490 citations

Conditioned Pain Modulation in Populations With Chronic Pain: A Systematic Review and Meta-Analysis

2012 • 487 citations

The Brain in Chronic CRPS Pain: Abnormal Gray-White Matter Interactions in Emotional and Autonomic Regions

2008 • 484 citations

Does Anticipation of Pain Affect Cortical Nociceptive Systems?

2002 • 464 citations

Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli

2003 • 445 citations

Asymbolia for pain: A sensory‐limbic disconnection syndrome

1988 • 435 citations

The underlying anatomical correlates of long-term meditation: Larger hippocampal and frontal volumes of gray matter

2009 • 435 citations

Pain-related cerebral activation is altered by a distracting cognitive task

2000 • 424 citations

The whole body receptive field of dorsal horn multireceptive neurones

2002 • 418 citations

PAIN IN MEN WOUNDED IN BATTLE

1946 • 416 citations

Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients

2009 • 409 citations

fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention

2002 • 399 citations

Region-specific encoding of sensory and affective components of pain in the human brain: A positron emission tomography correlation analysis

1999 • 396 citations

Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients

2006 • 395 citations

Fibromyalgia patients show an abnormal dopamine response to pain

2007 • 391 citations

Cortical thickness and pain sensitivity in zen meditators.

2010 • 385 citations

Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

2009 • 381 citations

Mood Influences Supraspinal Pain Processing Separately from Attention

2009 • 364 citations

Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation

2010 • 360 citations

Age effects on gray matter volume and attentional performance in Zen meditation

2007 • 357 citations

Responses of primate SI cortical neurons to noxious stimuli

1983 • 351 citations

The Spinothalamic System Targets Motor and Sensory Areas in the Cerebral Cortex of Monkeys

2009 • 343 citations

Effects of odors on pain perception: deciphering the roles of emotion and attention

2003 • 342 citations

Central Mechanisms of Pain Revealed Through Functional and Structural MRI

2012 • 340 citations

Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex

2008 • 339 citations

Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain

2009 • 339 citations

Cerebral Activation in Patients With Irritable Bowel Syndrome and Control Subjects During Rectosigmoid Stimulation

2001 • 332 citations

Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms

2005 • 331 citations

Elevated insular glutamate in fibromyalgia is associated with experimental pain

2009 • 296 citations

Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study

2000 • 294 citations

Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: A longitudinal voxel‐based morphometric study

2010 • 290 citations

Pain sensitivity alterations as a function of lesion location in the parasylvian cortex

1999 • 287 citations

Regular Exercise Reverses Sensory Hypersensitivity in a Rat Neuropathic Pain Model

2011 • 282 citations

A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators

2010 • 280 citations

Induction of Depressed Mood Disrupts Emotion Regulation Neurocircuitry and Enhances Pain Unpleasantness

2010 • 270 citations

Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala

2005 • 262 citations

A Comparison of Visceral and Somatic Pain Processing in the Human Brainstem Using Functional Magnetic Resonance Imaging

2005 • 262 citations

White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion‐tensor and volumetric imaging study

2008 • 262 citations

Variability of laser-evoked potentials: attention, arousal and lateralized differences

1993 • 260 citations

Mindfulness meditation-related pain relief: Evidence for unique brain mechanisms in the regulation of pain

2012 • 256 citations

Brain–computer interface using fMRI: spatial navigation by thoughts

2004 • 252 citations

MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain

2009 • 250 citations

Cerebral and spinal modulation of pain by emotions

2009 • 248 citations

Pain Attenuation through Mindfulness is Associated with Decreased Cognitive Control and Increased Sensory Processing in the Brain

2011 • 247 citations

Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura

2006 • 245 citations

Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study

1999 • 238 citations

Pain affect without pain sensation in a patient with a postcentral lesion

1999 • 237 citations

Parsing Pain Perception Between Nociceptive Representation and Magnitude Estimation

2008 • 234 citations

Love hurts: An fMRI study

2010 • 232 citations

Reduced Brainstem Inhibition during Anticipated Pelvic Visceral Pain Correlates with Enhanced Brain Response to the Visceral Stimulus in Women with Irritable Bowel Syndrome

2008 • 232 citations

Emotional valence contributes to music-induced analgesia

2007 • 231 citations

Anticipatory brainstem activity predicts neural processing of pain in humans

2006 • 227 citations

Chapter 14 Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain

1996 • 226 citations

SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation

1988 • 222 citations

Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgeia

2012 • 207 citations

Distraction Modulates Anterior Cingulate Gyrus Activations during the Cold Pressor Test

2001 • 207 citations

Pain imaging in health and disease — how far have we come?

2010 • 204 citations

Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators

2012 • 203 citations

The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation

2003 • 199 citations

Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia

2008 • 192 citations

Histochemical and immunocytochemical compartments of the thalamic VPM nucleus in monkeys and their relationship to the representational map

1991 • 190 citations

Alteration of cortical excitability in patients with fibromyalgia

2010 • 189 citations

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

2009 • 187 citations

Empathy hurts: Compassion for another increases both sensory and affective components of pain perception

2007 • 185 citations

Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome

2005 • 183 citations

Treating pain with pain: Supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation

2011 • 176 citations

Patients With Irritable Bowel Syndrome Have Altered Emotional Modulation of Neural Responses to Visceral Stimuli

2010 • 175 citations

Executive Function and Decision-Making in Women with Fibromyalgia

2009 • 174 citations

Gray matter changes related to chronic posttraumatic headache

2009 • 167 citations

Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval

1990 • 167 citations

Disruption of cognitive function in Fibromyalgia Syndrome ☆

2008 • 161 citations

CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

1994 • 160 citations

Differential brain opioid receptor availability in central and peripheral neuropathic pain

2006 • 160 citations

Modulation of pain processing in hyperalgesia by cognitive demand

2005 • 159 citations

Efficacy and effectiveness of cognitive behaviour therapy for chronic pain: Progress and some challenges

2010 • 156 citations

Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET

2004 • 151 citations

The cerebellum: organization, functions and its role in nociception

2003 • 150 citations

Cerebral Responses to Noxious Thermal Stimulation in Chronic Low Back Pain Patients and Normal Controls

2002 • 136 citations

White matter brain and trigeminal nerve abnormalities in temporomandibular disorder

2012 • 134 citations

Distraction as a key determinant of impaired memory in patients with fibromyalgia.

2006 • 130 citations

Experience-dependent plasticity in white matter microstructure: reasoning training alters structural connectivity

2012 • 128 citations

The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats

2009 • 127 citations

Assessment of the Effects of Aquatic Therapy on Global Symptomatology in Patients With Fibromyalgia Syndrome: A Randomized Controlled Trial

2008 • 119 citations

The role of rostral cingulumotomy in "pain" relief.

1968 • 109 citations

Novel Evidence for Hypersensitivity of Visceral Sensory Neural Circuitry in Irritable Bowel Syndrome Patients

2006 • 109 citations

Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study

2001 • 109 citations

Multiple white matter tract abnormalities underlie cognitive impairment in RRMS

2011 • 107 citations

Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain

2009 • 106 citations

Altered associative learning and emotional decision making in fibromyalgia

2010 • 104 citations

Flexible Cerebral Connectivity Patterns Subserve Contextual Modulations of Pain

2010 • 103 citations

Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain

2006 • 103 citations

Distraction and Placebo

2012 • 99 citations

White matter microstructural alterations in migraine: A diffusion-weighted MRI study

2012 • 98 citations

Bridging the hemispheres in meditation: Thicker callosal regions and enhanced fractional anisotropy (FA) in long-term practitioners

2012 • 94 citations

Experimentally Induced Mood Changes Preferentially Affect Pain Unpleasantness

2008 • 94 citations

Brain chemistry reflects dual states of pain and anxiety in chronic low back pain

2002 • 93 citations

Chronic pain‐induced emotional dysfunction is associated with astrogliosis due to cortical δ‐opioid receptor dysfunction

2006 • 92 citations

Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts

2008 • 92 citations

Long‐term potentiation of neuronal excitation by neuron–glia interactions in the rat spinal dorsal horn

2007 • 85 citations

Altered processing of pain‐related information in patients with fibromyalgia

2004 • 85 citations

Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory

2010 • 84 citations

Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems

2009 • 76 citations

Olfactory dysfunction, gambling task performance and intracranial lesions after traumatic brain injury.

2010 • 73 citations

1H-MR spectroscopic detection of metabolic changes in pain processing brain regions in the presence of non-specific chronic low back pain

2010 • 73 citations

The modulation of pain by attention and emotion: A dissociation of perceptual and spinal nociceptive processes

2011 • 70 citations

Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls

2007 • 70 citations

Attentional modulation of visceral and somatic pain

2007 • 70 citations

Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study.

2011 • 67 citations

Alterations in attentional mechanisms in response to acute inflammatory pain and morphine administration

2007 • 62 citations

Diffusion-Weighted and Diffusion Tensor Imaging in Fibromyalgia Patients: A Prospective Study of Whole Brain Diffusivity, Apparent Diffusion Coefficient, and Fraction Anisotropy in Different Regions of the Brain and Correlation With Symptom Severity

2007 • 61 citations

Fibromyalgia unique temporal brain activation during experimental pain: a controlled fMRI Study

2009 • 58 citations

Enriched environment and the recovery from inflammatory pain: Social versus physical aspects and their interaction

2009 • 57 citations

The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain

2012 • 52 citations

Thermoreceptive lamina I trigeminothalamic neurons project to the nucleus submedius in the cat

1991 • 52 citations

Differential SPECT Activation Patterns Associated with PASAT Performance May Indicate Frontocerebellar Functional Dissociation in Chronic Mild Traumatic Brain Injury

2009 • 48 citations

Nerve injury causes long-term attentional deficits in rats

2012 • 48 citations

Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in rats

2008 • 45 citations

Dynamic assessment of the right lateral frontal cortex response to painful stimulation

2010 • 44 citations

Behavioral and Neuronal Investigations of Hypervigilance in Patients with Fibromyalgia Syndrome

2012 • 43 citations

Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment

2007 • 38 citations

The opioid placebo analgesia is mediated exclusively through µ-opioid receptor in rat

2012 • 38 citations

Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running

2006 • 37 citations

Subjective estimates of chronic pain before and after psychosurgery or treatment in a pain unit

1981 • 37 citations

Pain Mechanisms and Management

1997 • 36 citations

The lateral ventromedial thalamic nucleus spreads nociceptive signals from the whole body surface to layer I of the frontal cortex

2005 • 34 citations

Proprioceptive pathways to posterior parietal areas MIP and LIPv from the dorsal column nuclei and the postcentral somatosensory cortex

2011 • 33 citations

Neurophysiological processes underlying the phantom limb pain experience and the use of hypnosis in its clinical management: An intensive examination of two patients

2001 • 30 citations

Mild head injury and sympathetic arousal: Investigating relationships with decision-making and neuropsychological performance in university students

2011 • 29 citations

Environmental housing affects the duration of mechanical allodynia and the spinal astroglial activation in a rat model of chronic inflammatory pain

2009 • 22 citations

Attentional modulation fails to attenuate the subjective pain experience in chronic, unexplained pain

2009 • 20 citations

Preoperative housing in an enriched environment significantly reduces the duration of post-operative pain in a rat model of knee inflammation

2009 • 17 citations

Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice

2009 • 13 citations

Environmental enrichment reduces mechanical hypersensitivity in neuropathic mice, but fails to abolish the phenotype of CCK2 receptor deficient mice

2009 • 6 citations

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