Evaluation of Susceptibility Testing To Detect Fluoroquinolone Resistance Mechanisms in Streptococcus pneumoniae

Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically

2000 • 16,578 citations

Decreased Susceptibility ofStreptococcus pneumoniaeto Fluoroquinolones in Canada

1999 • 1,012 citations

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae

1996 • 430 citations

Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong

1999 • 241 citations

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA

1996 • 232 citations

Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones

2000 • 230 citations

Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae

1998 • 202 citations

Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro

1996 • 176 citations

Primary Targets of Fluoroquinolones in Streptococcus pneumoniae

1999 • 166 citations

Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

1996 • 155 citations

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

1996 • 136 citations

Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae

1997 • 131 citations

The New Fluoroquinolones: A Critical Review

1999 • 128 citations

Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae : Contributions of Type II Topoisomerase Mutations and Efflux to Levels of Resistance

2000 • 122 citations

Activities of Newer Fluoroquinolones against Streptococcus pneumoniae Clinical Isolates Including Those with Mutations in the gyrA , parC , and parE Loci

1999 • 111 citations

Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus : Different Patterns of Quinolone- Induced Inhibition of DNA Synthesis

2000 • 97 citations

Contribution of Topoisomerase IV and DNA Gyrase Mutations in Streptococcus pneumoniae to Resistance to Novel Fluoroquinolones

1999 • 81 citations

THE SPECIFIC POLYSACCHARIDE CONTENT OF PNEUMONIC LUNGS

1942 • 56 citations

Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance

1995 • 54 citations