Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

DNA gyrase: an enzyme that introduces superhelical turns into DNA.

1976 • 1,175 citations

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

1977 • 828 citations

Pneumococcal resistance to antibiotics

1990 • 820 citations

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1991 • 784 citations

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

1976 • 719 citations

New topoisomerase essential for chromosome segregation in E. coli

1990 • 558 citations

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

1990 • 538 citations

Energy coupling in DNA gyrase and the mechanism of action of novobiocin

1978 • 403 citations

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

1994 • 376 citations

Topoisomerase IV is a target of quinolones in Escherichia coli.

1995 • 372 citations

The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

1992 • 337 citations

A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA

1979 • 325 citations

Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus

1995 • 278 citations

Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone‐resistant isolates

1994 • 271 citations

Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions.

1993 • 254 citations

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

1993 • 250 citations

DNA gyrase action involves the introduction of transient double-strand breaks into DNA.

1980 • 237 citations

Structure and function of the region of the replication origin of theBacillus subtilischromosome. III. Nucleotide sequence of some 10,000 base pairs in the origin region

1985 • 224 citations

Mapping the active site tyrosine of Escherichia coli DNA gyrase.

1987 • 207 citations

Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones

1989 • 205 citations

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction

1991 • 190 citations

DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli

1990 • 172 citations

Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition

1994 • 161 citations

Cloning and simplified purification of Escherichia coli DNA gyrase A and B proteins.

1984 • 143 citations

Mechanism of action of quinolones against Escherichia coli DNA gyrase

1993 • 115 citations

New quinolones and gram-positive bacteria

1994 • 115 citations

Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins

1992 • 100 citations

Analysis by PCR and direct DNA sequencing of gyrA mutations associated with fluoroquinolone resistance in Enterococcus faecalis

1994 • 77 citations

DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance

1990 • 61 citations

Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance

1995 • 54 citations

IS861, a group B streptococcal insertion sequence related to IS150 and IS3 of Escherichia coli

1989 • 51 citations

In Vitro Activity of Fluoroquinolones against Gram-Positive Bacteria

1995 • 50 citations

Inhibition by quinolones of DNA gyrase from Staphylococcus aureus

1991 • 44 citations

Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae

1994 • 43 citations

The Role of New Quinolones in the Treatment of Respiratory Tract Infections

1995 • 25 citations

Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants

1995 • 14 citations