Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3
Data up to Jan 2025
Total Citations Per Year
Abstract
References (37)
Atherosclerosis — An Inflammatory Disease
1999 • 21,494 citations
Calcium's Role in Mechanotransduction during Muscle Development
2014 • 14,293 citations
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
1994 • 3,219 citations
Flow-mediated endothelial mechanotransduction
1995 • 2,728 citations
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
1998 • 2,360 citations
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
1997 • 2,284 citations
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998 • 1,551 citations
TRAF6 is a signal transducer for interleukin-1
1996 • 1,287 citations
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1999 • 1,267 citations
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
1999 • 1,163 citations
Laminar Shear Stress
1998 • 1,052 citations
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
1995 • 1,046 citations
Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice
1997 • 791 citations
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
1997 • 712 citations
ASK1 Is Essential for JNK/SAPK Activation by TRAF2
1998 • 641 citations
Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State
1998 • 607 citations
Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death
1998 • 597 citations
Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx
1998 • 596 citations
Modulation of life and death by the TNF receptor superfamily
1998 • 543 citations
Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin
2000 • 533 citations
From receptors to stress-activated MAP kinases
1999 • 525 citations
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
1999 • 459 citations
TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival
1997 • 449 citations
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999 • 390 citations
Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways
1997 • 355 citations
Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction
1998 • 351 citations
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins
1999 • 351 citations
14-3-3 proteins block apoptosis and differentially regulate MAPK cascades
2000 • 285 citations
Differential Effect of Shear Stress on Extracellular Signal-regulated Kinase and N-terminal Jun Kinase in Endothelial Cells
1997 • 269 citations
Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
1999 • 254 citations
The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression
1996 • 234 citations
14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity
1998 • 219 citations
Stress-Activated Protein Kinases in Cardiovascular Disease
1996 • 204 citations
TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways.
1997 • 150 citations
Opposing Effects of Reactive Oxygen Species and Cholesterol on Endothelial Nitric Oxide Synthase and Endothelial Cell Caveolae
1999 • 141 citations
Stress-activated Protein Kinase/Jun N-terminal Kinase Is Required for Interleukin (IL)-1-induced IL-6 and IL-8 Gene Expression in the Human Epidermal Carcinoma Cell Line KB
1998 • 100 citations
The N-Terminal Domains Target TNF Receptor-Associated Factor-2 to the Nucleus and Display Transcriptional Regulatory Activity
1998 • 41 citations