Effects of Newer Antipsychotics on Extrapyramidal Function

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Risperidone in the treatment of schizophrenia

1994 • 1,205 citations

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1996 • 1,143 citations

Does Fast Dissociation From the Dopamine D₂ Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis

2001 • 1,113 citations

Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis

2000 • 1,079 citations

Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States

1993 • 948 citations

Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial

1997 • 906 citations

A Canadian Multicenter Placebo-Controlled Study of Fixed Doses of Risperidone and Haloperidol in the Treatment of Chronic Schizophrenic Patients

1993 • 884 citations

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials

1999 • 807 citations

Olanzapine versus Placebo and Haloperidol

1996 • 788 citations

Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo

1997 • 756 citations

Comparison of Risperidone and Placebo for Psychosis and Behavioral Disturbances Associated With Dementia

1999 • 726 citations

Double-Blind Comparison of Olanzapine Versus Risperidone in the Treatment of Schizophrenia and Other Psychotic Disorders

1997 • 722 citations

Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence

1998 • 719 citations

Clinical and Theoretical Implications of 5-HT₂ and D₂ Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

1999 • 706 citations

Tardive dystonia

1982 • 605 citations

Binding of antipsychotic drugs to human brain receptors

2000 • 594 citations

Olanzapine Versus Placebo in the Treatment of Acute Mania

1999 • 580 citations

Low-Dose Clozapine for the Treatment of Drug-Induced Psychosis in Parkinson's Disease

1999 • 577 citations

Risperidone in the Treatment of Patients with Chronic Schizophrenia: a Multi-National, Multi-Centre, Double-Blind, Parallel-Group Study versus Haloperidol

1995 • 558 citations

Efficacy of Olanzapine in Acute Bipolar Mania<subtitle>A Double-blind, Placebo-Controlled Study</subtitle>

2000 • 557 citations

Significance of Neuroleptic Dose and Plasma Level in the Pharmacological Treatment of Psychoses

1988 • 554 citations

Quetiapine in Patients With Schizophrenia

1997 • 487 citations

Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia

1994 • 391 citations

Olanzapine versus placebo: results of a double-blind, fixed-dose olanzapine trial

1996 • 387 citations

Evidence of Clozapine’s Effectiveness in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Trials

1999 • 357 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

Structural Evaluation of the Prefrontal Cortex in Schizophrenia

1998 • 314 citations

Receptor pharmacology of neuroleptics: relation to clinical effects.

1999 • 309 citations

Changes in Prevalence, Severity, and Recovery in Tardive Dyskinesia With Age

1980 • 308 citations

The Effects of Clozapine on Tardive Dyskinesia

1991 • 304 citations

Tolerability of Atypical Antipsychotics

2000 • 303 citations

Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: a multicentre double‐blind comparative study

1992 • 302 citations

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

1995 • 299 citations

The Risks and Benefits of Clozapine versus Chlorpromazine

1987 • 299 citations

Neuroleptic malignant syndrome: review and analysis of 115 cases

1987 • 289 citations

Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol

1997 • 287 citations

Risperidone Versus Clozapine in Treatment-Resistant Chronic Schizophrenia: A Randomized Double-Blind Study

1998 • 277 citations

ICI 204,636, an Atypical Antipsychotic

1996 • 275 citations

Understanding and Treating Tardive Dyskinesia

1983 • 269 citations

The Dopamine Receptors

1997 • 260 citations

Positive and Negative Symptom Response to Clozapine in Schizophrenic Patients With and Without the Deficit Syndrome

1998 • 258 citations

Akathisia Variants and Tardive Dyskinesia

1985 • 257 citations

Clozapine: neuroleptic-induced EPS and tardive dyskinesia

1989 • 256 citations

Lower Incidence of Tardive Dyskinesia with Risperidone Compared with Haloperidol in Older Patients

1999 • 231 citations

Agranulocytosis during treatment with clozapine

1977 • 229 citations

Prospective Study of Tardive Dyskinesia in the Elderly: Rates and Risk Factors

1998 • 227 citations

Reducing clozapine-related morbidity and mortality: 5 years of experience with the Clozaril National Registry.

1998 • 216 citations

Physiology of Basal Ganglia Disorders: An Overview

1993 • 215 citations

Clozapine in drug-induced psychosis in Parkinson's disease

1999 • 215 citations

New atypical antipsychotic medications

1998 • 215 citations

Atypical antipsychotics in the treatment of drug-induced psychosis in Parkinson's disease

2000 • 213 citations

Cognitive-behavioral therapy and treatment for late-life depression.

1996 • 204 citations

Olanzapine

2001 • 202 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Clozapine and Risperidone in Chronic Schizophrenia: Effects on Symptoms, Parkinsonian Side Effects, and Neuroendocrine Response

1999 • 198 citations

Quetiapine for the treatment of drug-induced psychosis in Parkinson's disease

1999 • 195 citations

Neuroleptic malignant syndrome. Review of response to therapy

1989 • 189 citations

Tardive dyskinesia: summary of a Task Force Report of the American Psychiatric Association. By the Task Force on Late Neurological Effects of Antipsychotic Drugs

1980 • 185 citations

A comparison of the effects of quetiapine (‘Seroquel’) and haloperidol in schizophrenic patients with a history of and a demonstrated, partial response to conventional antipsychotic treatment

2000 • 180 citations

Olanzapine in the treatment of dopaminomimetic psychosis in patients with Parkinson's disease

1996 • 175 citations

Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report

1995 • 172 citations

Neuroleptic Malignant Syndrome

1989 • 168 citations

Time course of central nervous dopamine-D 2 and 5-HT 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel ® ) in patients with schizophrenia

1998 • 167 citations

The trial use of clozapine for abnormal involuntary movement disorders

1979 • 162 citations

Quetiapine, A Novel Antipsychotic

1999 • 162 citations

Low Incidence of Persistent Tardive Dyskinesia in Elderly Patients With Dementia Treated With Risperidone

2000 • 161 citations

Relationship between dopaminergic and serotonergic neuronal activity in the frontal cortex and the action of typical and atypical antipsychotic drugs

1999 • 160 citations

Therapeutic Strategies Against Tardive Dyskinesia

1982 • 159 citations

Clozapine in tardive dyskinesia: observations from human and animal model studies.

1994 • 158 citations

Risperidone versus clozapine in the treatment of psychosis in six patients with Parkinson's disease and other akinetic-rigid syndromes.

1995 • 157 citations

Clozapine and Risperidone Treatment of Psychosis in Parkinson's Disease

2000 • 156 citations

Clozapine in the treatment of parkinsonian patients with dopaminomimetic psychosis

1990 • 150 citations

Risperidone in Treatment-Refractory Schizophrenia

1999 • 149 citations

Clozapine-Induced Neuroleptic Malignant Syndrome

1995 • 147 citations

The Prevalence of Acute Extrapyramidal Signs and Symptoms in Patients Treated With Clozapine, Risperidone, and Conventional Antipsychotics

1998 • 147 citations

The emergin role of clozapine in the treatment of movement disorders

1997 • 143 citations

Does clozapine cause tardive dyskinesia?

1993 • 140 citations

Predicting the long-term risk of tardive dyskinesia in outpatients maintained on neuroleptic medications.

1993 • 139 citations

Long-term safety and efficacy of amisulpride in subchronic or chronic schizophrenia

2000 • 138 citations

Managing Antipsychotic-Induced Acute and Chronic Akathisia

2000 • 136 citations

Clozapine in tardive dyskinesia

1978 • 131 citations

Clozapine-Associated Neuroleptic Malignant Syndrome: Two New Cases and a Review of the Literature

1999 • 130 citations

Do Central Antiadrenergic Actions Contribute to the Atypical Properties of Clozapine?

1992 • 130 citations

Clozapine in the treatment of tremor

2009 • 130 citations

Antipsychotic-Induced Movement Disorders in the Elderly

2000 • 129 citations

Treatment of drug-induced exogenous psychosis in Parkinsonism with clozapine and fluperlapine

1985 • 127 citations

Clozapine Treatment for Neuroleptic-Induced Tardive Dyskinesia, Parkinsonism, and Chronic Akathisia in Schizophrenic Patients

1997 • 123 citations

Neurologic side effects in neuroleptic-naive patients treated with haloperidol or risperidone

1999 • 119 citations

Treatment outcome with clozapine in tardive dyskinesia, neuroleptic sensitivity, and treatment-resistant psychosis.

1987 • 119 citations

Clozapine--a new antipsychotic agent.

1974 • 116 citations

Paradoxical response to dopamine agonists in tardive dyskinesia

1977 • 112 citations

Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment.

2001 • 112 citations

Incidence of tardive dyskinesia: five-year data from a prospective study.

1984 • 112 citations

Treatment of severe axial tardive dystonia with clozapine: Case report and hypothesis

1994 • 110 citations

Neuroleptic malignant syndrome: a review of the literature.

1986 • 110 citations

Brain Dopamine Receptors: A Primer on Their Current Status, Basic and Clinical

1996 • 110 citations

Risperidone Versus Haloperidol and Amitriptyline in the Treatment of Patients With a Combined Psychotic and Depressive Syndrome

1998 • 106 citations

Review of quetiapine and its clinical applications in schizophrenia

2000 • 106 citations

Extrapyramidal Signs and Clinical Symptoms in First-Episode Schizophrenia

1997 • 106 citations

Clozapine‐responsive tremor in Parkinson's disease

1990 • 105 citations

Efficacy of Quetiapine in Parkinson's Patients With Psychosis

2000 • 104 citations

Atypical Antipsychotics and Neuroleptic Malignant Syndrome

2000 • 103 citations

A combined analysis of double‐blind studies with risperidone vs. placebo and other antipsychotic agents: factors associated with extrapyramidal symptoms

1999 • 98 citations

Benztropine versus clozapine for the treatment of tremor in Parkinson's disease

1997 • 97 citations

Dopamine- and serotonin-receptors in schizophrenia: results of imaging-studies and implications for pharmacotherapy in schizophrenia

1999 • 96 citations

The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease

1997 • 94 citations

The treatment of tardive dyskinesia—a systematic review and meta-analysis

1999 • 94 citations

Neuroleptic Malignant Syndrome

1986 • 93 citations

Prevalence and severity of akathisia in patients on clozapine

1991 • 93 citations

Antipsychotic Medications and the Elderly

2001 • 92 citations

ICI 204,636, a novel, atypical antipsychotic: early indication of safety and efficacy in patients with chronic and subchronic schizophrenia

1995 • 92 citations

An example of European multicenter trials: multispectral analysis of clozapine.

1976 • 89 citations

Low-dose clozapine improves dyskinesias in Parkinson's disease

1997 • 88 citations

The new generation of antipsychotic drugs: how atypical are they?

2000 • 87 citations

Quetiapine (Seroquel) in the Treatment of Psychosis in Patients With Parkinson's Disease

1998 • 84 citations

Movement disorders in neurology and neuropsychiatry

1992 • 83 citations

Clozapine in Parkinson's disease tremor

1997 • 81 citations

Suppression of dyskinesias in advanced Parkinson's disease

1993 • 81 citations

Olanzapine in the treatment of hallucinosis in idiopathic parkinson's disease: a cautionary note

1998 • 80 citations

Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia

1998 • 80 citations

Suppression of dyskinesias in advanced Parkinson's disease: Moderate daily clozapine doses provide long‐term dyskinesia reduction

1994 • 78 citations

Worsening of motor features of Parkinsonism with olanzapine

1999 • 77 citations

Olanzapine for Psychosis in Patients With Parkinson's Disease With and Without Dementia

1999 • 77 citations

The Safety of Olanzapine Compared With Other Antipsychotic Drugs

2000 • 75 citations

Different side effect profiles of risperidone and clozapine in 20 outpatients with schizophrenia or schizoaffective disorder: a pilot study

1996 • 74 citations

Clozapine in Huntington's chorea

1994 • 73 citations

Risperidone versus clozapine in treatment-resistant schizophrenia: A randomized pilot study

2000 • 73 citations

Dopamine D4 receptors: significance for molecular psychiatry at the millennium

1999 • 71 citations

Clozapine versus typical antipsychotics a retro- and prospective study of extrapyramidal side effects

1996 • 71 citations

Tardive Dyskinesia: Research & Treatment

2012 • 70 citations

Low-dose olanzapine for levodopa induced dyskinesias

2000 • 69 citations

Clozapine-induced neuroleptic malignant syndrome.

1991 • 69 citations

Effect of clozapine in severe tardive dyskinesia: a case report.

1984 • 68 citations

Clozapine in the treatment of tremor in Parkinson's disease

2009 • 68 citations

Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells

1991 • 68 citations

Risperidone treatment of drug-related psychosis in patients with parkinsonism

2000 • 68 citations

Risperidone

1994 • 67 citations

Hypokinesia in Huntington's disease

1996 • 66 citations

Ten-year outcome of tardive dyskinesia

1994 • 65 citations

Clozapine-related tardive dyskinesia

1994 • 64 citations

Clozapine use in diffuse Lewy body disease

1993 • 64 citations

Clozapine treatment of psychosis in patients with tardive dystonia: Report of three cases

1994 • 62 citations

Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias

1974 • 62 citations

Tardive Dyskinesia

1984 • 62 citations

Risperidone in levodopa‐induced psychosis in advanced parkinson's disease: An open‐label, long‐term study

1997 • 62 citations

Differences between antipsychotic drugs in persistence of brain levels and behavioral effects

1992 • 61 citations

Experimental neurological syndromes and thenew drug therapies in psychiatry

1960 • 61 citations

Nocturnal akathisia in parkinson's disease: Treatment with clozapine

1993 • 59 citations

Treatment of parkinsonian tremor with clozapine

1990 • 58 citations

Motor and mental side effects of clozapine.

1994 • 55 citations

Zotepine in the prevention of recurrence: a randomised, double-blind, placebo-controlled study for chronic schizophrenia

2000 • 54 citations

[Antipsychotic drugs and cardiovascular safety: current studies of prolonged QT interval and risk of ventricular arrhythmia].

2001 • 53 citations

Substituting clozapine for olanzapine in psychiatrically stable Parkinson's disease patients: results of an open label pilot study.

1998 • 53 citations

Prevalence of extrapyramidal syndromes in psychiatric inpatients and the relationship of clozapine treatment to tardive dyskinesia

2000 • 53 citations

Clozapine treatment of psychiatric symptoms resistant to neuroleptic treatment in patients with Huntington's chorea

1991 • 52 citations

Drug Evaluations: Drug Evaluation Central & Peripheral Nervous Systems: ‘Seroquel’ (quetiapine): Preclinical and clinical findings of a new atypical antipsychotic

1996 • 52 citations

Effect of Clozapine in Severe Tardive Dyskinesia

1984 • 52 citations

Reversal by Physostigmine of Clozapine-Induced Delirium

1977 • 52 citations

Brief report: risperidone for severely disturbed behavior and tardive dyskinesia in developmentally disabled adults.

1997 • 51 citations

A Structured Trial of Risperidone for the Treatment of Agitation in Dementia

1998 • 49 citations

Clozapine replacement by quetiapine for the treatment of drug-induced psychosis in Parkinson's disease

2000 • 48 citations

Clozapine treatment of spasmodic torticollis

1994 • 47 citations

The prevalence of akathisia in patients receiving stable doses of clozapine.

1994 • 45 citations

Modulatory effect of clozapine on levodopa response in parkinson's disease: A preliminary study

1993 • 45 citations

Reduction of Tardive Dystonia With Olanzapine

1999 • 44 citations

Clozapine versus Perphenazine: The Value of the Biochemical Mode of Action of Neuroleptics in Predicting their Therapeutic Activity

1976 • 43 citations

Quetiapine as an alternative to clozapine in the treatment of dopamimetic psychosis in patients with Parkinson's disease.

1999 • 41 citations

Risperidone‐induced tardive dyskinesia and parkinsonism

1997 • 41 citations

Clozapine in the Treatment of Tardive Dyskinesia: an Interim Report

1980 • 40 citations

The Role of Atypical Antipsychotics in the Treatment of Movement Disorders

1999 • 40 citations

Clozapine and Risperidone Treatment of Psychosis in Parkinson's Disease

2000 • 40 citations

GILLES DE LA TOURETTE'S SYNDROME

1964 • 39 citations

Therapeutic Value of Thioproperazine and the Importance of the Associated Neurological Disturbances

1961 • 39 citations

Olanzapine Use in the Elderly: A Retrospective Analysis

2000 • 39 citations

The use of fluoxetine and buspirone for treatment-refractory depersonalization disorder.

1995 • 39 citations

Risperidone for the Treatment of Behavioral Disturbances in Dementia

1998 • 38 citations

An assessment of iloperidone for the treatment of schizophrenia

2000 • 36 citations

Ziprasidone: comprehensive overview and clinical use of a novel antipsychotic

2000 • 35 citations

Quetiapine as an Alternative to Clozapine in the Treatment of Dopamimetic Psychosis in Patients with Parkinson's Disease

1999 • 35 citations

Neuroleptic Malignant Syndrome Associated With Clozapine Monotherapy

1993 • 34 citations

Risperidone Treatment of Behavioral Disturbances in Outpatients With Dementia

1999 • 32 citations

American Psychiatry After World War II (1944–1994)

2000 • 32 citations

Clozapine and jaw dyskinesia: a case report.

1991 • 32 citations

Risperidone in the Treatment of Patients With Alzheimer's Disease With Negative Symptoms

2000 • 32 citations

Clozapine, negative symptoms, and extrapyramidal side effects.

1994 • 31 citations

THE EFFECT OF CLOZAPINE on Preexisting Tardive Dyskinesia

1993 • 30 citations

Olanzapine vs placebo in the treatment of acute mania

1998 • 30 citations

Clozapine for the Control of Hemiballismus

1994 • 28 citations

Medial prefrontal cortical D2 and striatolimbic D4 dopamine receptors: Common targets for typical and atypical antepsychotic drugs

1998 • 27 citations

Drug Trials in Persistent Dyskinesia

1980 • 26 citations

Dopamine Receptors and Clinical Medicine

1997 • 24 citations

Comparative Efficacy of Risperidone and Clozapine in the Treatment of Patients With Refractory Schizophrenia or Schizoaffective Disorder

2000 • 23 citations

Tardive dyskinesia

2000 • 23 citations

Risperidone and Neuroleptic Malignant Syndrome

1996 • 23 citations

Psychiatric Manifestations of Olivo-Ponto-Cerebellar Atrophy and Treatment with Clozapine

1993 • 22 citations

Does clozapine cause neuroleptic malignant syndrome?

1993 • 22 citations

[Extrapyramidal symptoms following Clozapine therapy. Case report].

1975 • 19 citations

Barriers to progress-the impact of tolerability problems

2001 • 18 citations

Tolerability and effectiveness of atypical antipsychotics in male geriatric inpatients

2001 • 18 citations

Rapid onset tardive dyskinesia ("fly catcher tongue") in a neuroleptically naive patient induced by risperidone.

1998 • 18 citations

Quetiapine

2000 • 18 citations

Risperidone and neuroleptic malignant syndrome.

1996 • 17 citations

Successful treatment of hemichorea with olanzapine

1999 • 13 citations

Affinity of neuroleptics for D1 receptor of human brain striatum.

1994 • 11 citations

Role of Newer Atypical Antipsychotics in the Management of Treatment- Resistant Schizophrenia

2000 • 11 citations

Trastornos neuropsiquiátricos en la enfermedad de Parkinson

2001 • 11 citations

Olanzapine treatment of clozapine-induced NMS

2000 • 8 citations

Antipsychotic drug use in neurodegenerative disease in the elderly: problems and potential from a pharmacological perspective

2001 • 6 citations

Movement Disorders in Neurology and Neuropsychiatry, 2nd ed

2000 • 6 citations

Multireceptor atypical antipsychotic drugs

2000 • 5 citations

Amisulpride: its role in the therapeutic management of the schizophrenia patient. Conclusions.

2000 • 2 citations

Psychopharmacologic issues in the maintenance treatment of schizophrenia.

1984 • 2 citations

Deleted Work

1955 • 0 citations