Antipsychotic Medications and the Elderly

“Mini-mental state”

1975 • 82,784 citations

Normative data on a battery of neuropsychological tests in the Han Chinese population

2010 • 20,181 citations

Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review

2013 • 20,010 citations

Older Adults' Reasons for Using Technology while Aging in Place

2015 • 19,091 citations

Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly

2014 • 18,386 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

APRIORITY

1961 • 1,293 citations

Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.

1998 • 792 citations

The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

1996 • 730 citations

Comparison of Risperidone and Placebo for Psychosis and Behavioral Disturbances Associated With Dementia

1999 • 726 citations

Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence

1998 • 719 citations

Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease

1983 • 712 citations

Clinical and Theoretical Implications of 5-HT₂ and D₂ Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

1999 • 706 citations

A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease

1992 • 618 citations

Neuroleptic sensitivity in patients with senile dementia of Lewy body type.

1992 • 609 citations

A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia

1999 • 599 citations

Low-Dose Clozapine for the Treatment of Drug-Induced Psychosis in Parkinson's Disease

1999 • 577 citations

Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys

1994 • 574 citations

Senile dementia of Lewy body type

1990 • 573 citations

Novel antipsychotics: comparison of weight gain liabilities.

1999 • 532 citations

Serotonin in Aging, Late-Life Depression, and Alzheimer's Disease: The Emerging Role of Functional Imaging

1998 • 493 citations

Is the mesocortical dopaminergic system involved in Parkinson disease?

1980 • 412 citations

The Mechanism of Action of Novel Antipsychotic Drugs

1991 • 410 citations

A Randomized Trial of a Program to Reduce the Use of Psychoactive Drugs in Nursing Homes

1992 • 401 citations

Novel Antipsychotics

1999 • 389 citations

Ziprasidone 80 mg/day and 160 mg/day in the Acute Exacerbation of Schizophrenia and Schizoaffective Disorder A 6-Week Placebo-Controlled Trial

1999 • 387 citations

Dopaminergic A10 neurones are involved in cognitive functions

1980 • 362 citations

Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia.

1989 • 357 citations

Acetylcholine, Aging, and Alzheimer's Disease

1997 • 355 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

Receptor pharmacology of neuroleptics: relation to clinical effects.

1999 • 309 citations

Risk of Tardive Dyskinesia in Older Patients

1995 • 302 citations

Anticholinergic Sensitivity in Patients With Dementia of the Alzheimer Type and Age-Matched Controls

1987 • 295 citations

Psychotic symptoms and the longitudinal course of senile dementia of the Alzheimer type

1989 • 293 citations

Tolerance of debility in elderly dependants by supporters at home: its significance for hospital practice.

1975 • 291 citations

Ziprasidone 40 and 120 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 4-week placebo-controlled trial

1998 • 273 citations

Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia.

1989 • 271 citations

Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys

1995 • 259 citations

Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up

1997 • 255 citations

A Randomized, Placebo-Controlled Dose-Comparison Trial of Haloperidol for Psychosis and Disruptive Behaviors in Alzheimer’s Disease

1998 • 236 citations

Prospective Study of Tardive Dyskinesia in the Elderly: Rates and Risk Factors

1998 • 227 citations

Clozapine in drug-induced psychosis in Parkinson's disease

1999 • 215 citations

Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques

1989 • 199 citations

Quetiapine for the treatment of drug-induced psychosis in Parkinson's disease

1999 • 195 citations

Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.

1989 • 184 citations

Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients

1982 • 175 citations

Olanzapine in the treatment of dopaminomimetic psychosis in patients with Parkinson's disease

1996 • 175 citations

Olanzapine in the Treatment of Delirium

1998 • 173 citations

Emergence of psychosis and depression in the longitudinal evaluation of Alzheimer's disease

1991 • 171 citations

The relationship of pharmacology to side effects.

1997 • 169 citations

Time course of central nervous dopamine-D 2 and 5-HT 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel ® ) in patients with schizophrenia

1998 • 167 citations

Quetiapine, A Novel Antipsychotic

1999 • 162 citations

In vitro and in vivo biochemistry of olanzapine: a novel, atypical antipsychotic drug.

1997 • 155 citations

Cognitive change following MPTP exposure

1990 • 146 citations

Does clozapine cause tardive dyskinesia?

1993 • 140 citations

Preclinical pharmacology of neuroleptics: focus on new generation compounds.

1996 • 135 citations

Olanzapine in dementia with Lewy bodies: a clinical study

1999 • 117 citations

Efficacy of risperidone treatment for psychoses associated with schizophrenia, schizoaffective disorder, bipolar disorder, or senile dementia in 11 geriatric patients: a case series.

1995 • 111 citations

Delusions in dementia syndromes: investigation of behavioral and neuropsychological correlates

1991 • 108 citations

Alzheimer's disease and its Lewy body variant: a clinical analysis of postmortem verified cases

1996 • 108 citations

Withdrawal of Haloperidol, Thioridazine, and Lorazepam in the Nursing Home

1999 • 107 citations

Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer’s disease

1999 • 102 citations

A Pilot Study of Haloperidol Treatment of Psychosis and Behavioral Disturbance in Alzheimer's Disease

1989 • 102 citations

Differential effect of antipsychotics on place navigation of rats in the Morris water maze

1996 • 100 citations

Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and11C-raclopride

1993 • 98 citations

The efficacy, safety, and tolerability of antipsychotics in the elderly.

1999 • 95 citations

The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease

1997 • 94 citations

Muscarinic m4 receptor activation by some atypical antipsychotic drugs

1997 • 93 citations

Nursing home placement is related to dementia progression

1999 • 93 citations

Psychotic features and the course of Alzheimer's disease: relationship to cognitive, electroencephalographic and computerized tomography findings

1993 • 87 citations

Dopamine D 4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys

1999 • 86 citations

Quetiapine (Seroquel) in the Treatment of Psychosis in Patients With Parkinson's Disease

1998 • 84 citations

A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers

1999 • 84 citations

Treatment of agitation in dementia.

1999 • 83 citations

The Efficacy and Safety of Clozapine Versus Chlorpromazine in Geriatric Schizophrenia

1999 • 82 citations

Effects of Antipsychotic Withdrawal in Elderly Nursing Home Residents

1994 • 82 citations

Risperidone in the Elderly

1997 • 81 citations

Physical Restraint Use and Cognitive Decline among Nursing Home Residents

1992 • 81 citations

Olanzapine in the treatment of hallucinosis in idiopathic parkinson's disease: a cautionary note

1998 • 80 citations

Radiofrequency lesion of the ventral mesencephalic tegmentum: Neurological and behavioral considerations

1976 • 77 citations

Potential Adverse Outcomes of Psychotropic and Narcotic Drug Use in Canadian Seniors

1997 • 76 citations

Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match to position paradigm

1995 • 72 citations

Neuroleptic Sensitivity to Clozapine in Dementia With Lewy Bodies

1998 • 71 citations

Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 64 citations

Lewy Body Disease and Dementia

1996 • 64 citations

Olanzapine can worsen parkinsonism

1998 • 63 citations

Substituting clozapine for olanzapine in psychiatrically stable Parkinson's disease patients: results of an open label pilot study.

1998 • 53 citations

Institutionalization of Alzheimer's Disease Patients

1987 • 50 citations

Psychoses in the elderly: a spectrum of disorders.

1999 • 44 citations

Olanzapine for Psychotic Conditions in the Elderly

2000 • 43 citations

Antipsychotics in the elderly

1990 • 39 citations

Risperidone for the Treatment of Behavioral Disturbances in Dementia

1998 • 38 citations

Pharmacological differentation of classical and novel antipsychotics

1998 • 37 citations

Preferential activation of cortical dopamine neurotransmission by clozapine: functional significance.

1994 • 36 citations

Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man

1975 • 34 citations

Treatment of agitation in dementia

1997 • 30 citations

Risperidone in Elderly Schizophrenic Patients: An Open-Label Trial

1996 • 30 citations

Olanzapine therapy in elderly patients with schizophrenia.

1998 • 29 citations

Antipsychotic drug use in older adults

1994 • 27 citations

Clozapine as a treatment for psychosis in Parkinson's disease: a review

1996 • 26 citations

Neuroleptic dose reduction in older psychotic patients

1997 • 26 citations

Antipsychotics in Older Patients

1995 • 24 citations

Pharmacological Management of Schizophrenia in Older Patients

1994 • 18 citations

Dementia Testing in the Elderly

1993 • 17 citations

Neuroleptic treatment of elderly patients.

1995 • 15 citations

Chronic neuroleptic effects on spatial reversal learning in monkeys

1989 • 7 citations

Effects of haloperidol on motor and cognitive functioning in aged mice

1991 • 7 citations

Influence of thioridazine on human cognitive, psychomotor, and reaction performance as well as subjective feelings.

1983 • 6 citations