Evidence of Clozapine’s Effectiveness in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Trials

Meta-analysis in clinical trials

1986 • 36,193 citations

Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials

1995 • 5,696 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Improving the quality of reporting of randomized controlled trials. The CONSORT statement

1996 • 3,395 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Publication bias in clinical research

1991 • 3,034 citations

Systematic Reviews: Rationale for systematic reviews

1994 • 1,609 citations

Statistics Notes: Detecting skewness from summary information

1996 • 1,283 citations

Meta-Analyses of Randomized Controlled Trials

1987 • 1,278 citations

Language bias in randomised controlled trials published in English and German

1997 • 1,002 citations

Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States

1993 • 948 citations

Bias in Treatment Assignment in Controlled Clinical Trials

1983 • 889 citations

Understanding controlled trials: What are pragmatic trials?

1998 • 670 citations

Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews

1996 • 543 citations

A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia

1997 • 512 citations

The Science of Reviewing Researcha

1993 • 465 citations

Cochrane Collaboration Handbook

1996 • 405 citations

Childhood-Onset Schizophrenia

1996 • 395 citations

Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia

1994 • 391 citations

The Risks and Benefits of Clozapine versus Chlorpromazine

1987 • 299 citations

Positive and Negative Symptom Response to Clozapine in Schizophrenic Patients With and Without the Deficit Syndrome

1998 • 258 citations

Effects of clozapine on cognitive function in schizophrenia.

1994 • 200 citations

CLOZAPINE AND HALOPERIDOL IN A SINGLE‐BLIND CROSS‐OVER TRIAL: THERAPEUTIC AND BIOCHEMICAL ASPECTS IN THE TREATMENT OF SCHIZOPHRENIA

1974 • 198 citations

Clozapine's effectiveness for patients in state hospitals: results from a randomized trial.

1996 • 171 citations

Clozapine in tardive dyskinesia: observations from human and animal model studies.

1994 • 158 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

1975 • 138 citations

Clozapine Eligibility Among State Hospital Patients

1996 • 107 citations

Ergebnisse eines Doppelblindversuches von HF 1854^*(8-Chlor-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b, e) (1,4) diazepin) im Vergleich zu Levomepromazin

1971 • 90 citations

An example of European multicenter trials: multispectral analysis of clozapine.

1976 • 89 citations

Clozapine in China: a review and preview of US/PRC collaboration

1989 • 81 citations

Clozapine versus chlorpromazine for the treatment of schizophrenia: preliminary results from a double-blind study.

1979 • 72 citations

Clozapine (Leponex) compared with chlorpromazine: a double-blind evaluation of pharmacological and clinical properties.

1974 • 71 citations

A double-blind comparative study of clozapine versus chlorpromazine on Chinese patients with treatment-refractory schizophrenia

1997 • 57 citations

Double-Blind Comparison of Clozapine with Chlorpromazine in Acute Schizophrenic Illness

1976 • 45 citations

Clozapine versus Perphenazine: The Value of the Biochemical Mode of Action of Neuroleptics in Predicting their Therapeutic Activity

1976 • 43 citations

The tolerabilitv and efficacv of the atypical neuroleptic remoxipride cokpared with clozapine and haloperidol in acute schizophrenia

1994 • 28 citations

Clinical observations with beta-endorphin injections.

1978 • 15 citations

Some Methodological Considerations for the Clinical Evaluation of Neuroleptics-Comparative Effects of Clozapine and Haloperidol on Schizophrenics

1977 • 15 citations

Efficacy of clozapine versus haloperidol in a long-term clinical trial

1996 • 12 citations

[Application of NOSIE in the study of neuroleptic treatment].

1987 • 9 citations

[A double-blind study on the effect of clozapine penfluridol and chlorpromazine in the treatment of schizophrenia].

1988 • 7 citations

Utprøving av et nytt nevroleptikum, Leponex (clozapin) hos schizofrene med lang sykehistorie

1981 • 5 citations

[Three antipsychotic drugs in the treatment of schizophrenia--a controlled and double-blind study].

1988 • 4 citations

Effectiveness of clozapine in treatment resistant schizophrenia

1997 • 3 citations

Clozapine vs. haloperidol: Drug intolerance in a controlled six month trial

1997 • 2 citations