A role for reduced oxygen species in heat induced cell killing and the induction of thermotolerance

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

1982 • 754 citations

Lipid Peroxides in Biology and Medicine

1982 • 640 citations

Stress protein systems of mammalian cells

1986 • 564 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 530 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Synthesis and degradation of heat shock proteins during development and decay of thermotolerance.

1982 • 433 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

AppppA, heat-shock stress, and cell oxidation.

1983 • 379 citations

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1980 • 343 citations

Induction of thermotolerance and enhanced heat shock protein synthesis in chinese hamster fibroblasts by sodium arsenite and by ethanol

1983 • 306 citations

Mammalian Cells Are Not Killed by DNA Single-Strand Breaks Caused by Hydroxyl Radicals from Hydrogen Peroxide

1985 • 305 citations

AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress

1984 • 303 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Superoxide Radical and Hydrogen Peroxide in Mitochondria

1982 • 273 citations

Interaction of Hyperthermia and Radiation in CHO Cells: Recovery Kinetics

1976 • 238 citations

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

1984 • 229 citations

Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen

1983 • 227 citations

Induction of four proteins in chick embryo cells by sodium arsenite.

1980 • 219 citations

[32] Chemistry of lipid peroxidation

1984 • 219 citations

The Actions and Metabolic Fate of Disulfiram

1981 • 213 citations

The Toxicology of Molecular Oxygen

1984 • 210 citations

Ethanol-induced tolerance to heat and to adriamycin

1978 • 201 citations

Experimental activation of specific loci in polytene chromosomes of Drosophila

1964 • 200 citations

The biochemical mechanism of selective heat sensitivity of cancer cells

1969 • 174 citations

Elevated levels of 70,000 dalton heat shock protein in transiently thermotolerant chinese hamster fibroblasts and in their stable heat resistant variants

1985 • 173 citations

Modulation of heat shock polypeptide synthesis in HeLa cells during hyperthermia and recovery

1982 • 162 citations

Generation of H2O2 in biomembranes

1982 • 158 citations

Involvement of Membranes in Cellular Responses to Hyperthermia

1982 • 154 citations

Relationship between hyperthermia-induced heat-shock proteins and thermotolerance in Morris hepatoma cells

1983 • 148 citations

Thiols, Thiol Depletion, and Thermosensitivity

1983 • 132 citations

Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion.

1983 • 131 citations

Hypoxia and drug metabolism

1981 • 122 citations

Rapid increases in inositol trisphosphate and intracellular Ca++ after heat shock

1986 • 114 citations

Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage

1985 • 108 citations

Induced thermal tolerance and heat shock protein synthesis in Chinese hamster ovary cells

1982 • 100 citations

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin.

1986 • 96 citations

The Radiosensitization of Hypoxic Tumor Cells by Hyperthermia

1975 • 90 citations

The effect of changes in the respiratory metabolism upon genome activity in Drosophila

1972 • 88 citations

Interrelation between lipid peroxidation and other hepatotoxic events

1984 • 88 citations

Review: Metabolic changes during and after hyperthermia

1985 • 82 citations

Effect of extracellular pH on thermotolerance and recovery of hyperthermic damage in vitro.

1979 • 79 citations

Heat-Stress Proteins and Thermal Resistance in Rat Mammary Tumor Cells

1983 • 78 citations

COULD SUPEROXIDE CAUSE CIRRHOSIS?

1982 • 77 citations

Similarities in Cellular Inactivation by Hyperthermia or by Ethanol

1980 • 77 citations

Induction of the Drosophila heat shock response in isolated polytene nuclei

1978 • 75 citations

Factors Influencing the Oxidation of Cysteamine and Other Thiols: Implications for Hyperthermic Sensitization and Radiation Protection

1984 • 74 citations

Superoxide dismutase levels in Chinese hamster ovary cells and ovarian carcinoma cells after hyperthermia or exposure to cycloheximide.

1985 • 74 citations

The possible role of the superoxide ion in the induction of heat-shock and specific proteins in aerobic Drosophila cells during return to normoxia after a period of anaerobiosis

1983 • 73 citations

Modification of the Heat Response and Thermotolerance by Cycloheximide, Hydroxyurea, and Lucanthone in CHO Cells

1982 • 73 citations

Superoxide dismutase: an evolutionary puzzle.

1985 • 72 citations

The effect of low pH on thermotolerance induction using fractionated 45 degrees C hyperthermia.

1981 • 71 citations

Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat

1985 • 69 citations

Menkes' disease: Abnormal metallothionein gene regulation in response to copper

1985 • 62 citations

The role of energy in hyperthermia‐induced mammalian cell inactivation: A study of the effects of glucose starvation and an uncoupler of oxidative phosphorylation

1981 • 61 citations

Enhancement of mitochondrial, cyanide-resistant superoxide dismutase in the livers of rats treated with 2,4-dinitrophenol.

1980 • 60 citations

Dexamethasone can modulate glucose‐regulated and heat shock protein synthesis

1983 • 60 citations

Diethyldithiocarbamate Enhancement of Radiation and Hyperthermic Effects on Chinese Hamster Cells in Vitro

1979 • 58 citations

The effects of glutathione depletion on thermotolerance and heat stress protein synthesis

1984 • 55 citations

Heat protection by glycerol in vitro.

1982 • 53 citations

Quantitative and mechanistic aspects of the hydroperoxide‐induced release of Ca²⁺ from rat liver mitochondria

1985 • 52 citations

Enhancement of hyperthermia-induced cytotoxicity by polyamines.

1980 • 50 citations

Enhancement of cysteamine cytotoxicity by hyperthermia and its modification by catalase and superoxide dismutase in Chinese hamster ovary cells.

1984 • 45 citations

Cellular glutathione, thermal sensitivity, and thermotolerance in Chinese hamster fibroblasts and their heat-resistant variants.

1986 • 45 citations

Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells.

1979 • 45 citations

Metabolite regulation of heat shock protein levels.

1983 • 45 citations

Preparation of a Plasma Membrane Fraction from Rat Liver by Zonal Centrifugation

1970 • 45 citations

Mechanism of Spermidine Cytotoxicity at 37°C and 43°C in Chinese Hamster Ovary Cells

1986 • 44 citations

Heat-Induced Thermotolerance Expressed in the Energy Metabolism of Mammalian Cells

1983 • 44 citations

The Effect of Low pH on Thermotolerance Induction Using Fractionated 45°C Hyperthermia

1981 • 44 citations

Heat Shock Protein Levels Are Not Elevated in Heat-Resistant B16 Melanoma Cells

1986 • 43 citations

Molecular Structure and Expression of the Gene Locus on Chromosome 21 Encoding the Cu/Zn Superoxide Dismutase and Its Relevance to Down Syndromea

1985 • 43 citations

Effects of Thermal Treatment on Mitochondria of Brain, Liver and Ascites Cells

1969 • 42 citations

A genetic approach to the role of energy metabolism in the growth of tumor cells: Tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration

1981 • 40 citations

Separate glucocorticoid, heavy metal, and heat shock domains in thymic lymphocytes.

1983 • 40 citations

Nitrogen metabolism and lipid peroxidation during hyperthermic perfusion of human livers with cancer.

1986 • 39 citations

Selective potentiation of hyperthermic killing of hypoxic cells by 5-thio-D-glucose.

1978 • 39 citations

Catalase is Induced by Ecdysterone and Ethanol in Drosophila Cells

1982 • 38 citations

Comparison of the effects of heat shock and metal-ion stress on gene expression in cells undergoing myogenesis

1983 • 37 citations

Selective killing of glucose and oxygen-deprived HeLa cells by hyperthermia.

1980 • 37 citations

MICROSOMAL LIPID PEROXIDATION: MECHANISM AND SOME BIOMEDICAL IMPLICATIONS

1982 • 37 citations

Induction of puffs in Drosophila salivary gland cells by mitochondrial factor(s)

1975 • 35 citations

Role of glutathione in cell survival after hyperthermic treatment of Chinese hamster ovary cells.

1985 • 35 citations

The crucial role of hypoxia in halothane-induced lipid peroxidation

1984 • 34 citations

Chemically Induced Resistance to Heat Treatment and Stress Protein Synthesis in Cultured Mammalian Cells

1986 • 29 citations

Effect of temperature on biochemical functions in the isolated perfused rat liver

1978 • 28 citations

Antagonistic effects of insulin and dexamethasone on glucose‐regulated and heat shock protein synthesis

1985 • 28 citations

Effects of 2,4-dinitrophenol and dinactin on heat-sensitive and ecdysone-specific puffs of Drosophila salivary gland chromosomes in vitro

1973 • 26 citations

On the adaptation of cultured chick embryo cells to growth in the presence of chloramphenicol

1979 • 26 citations

On the Importance of the Level of Glutathione and the Activity of the Pentose Phosphate Pathway in Heat Sensitivity and Thermotolerance

1985 • 25 citations

Hyperthermia-induced cell death, thermotolerance, and heat shock proteins in normal, respiration-deficient, and glycolysis-deficient Chinese hamster cells.

1986 • 24 citations

Enhancing hyperthermic cytotoxicity in L929 cells by energy source restriction and insulin exposure.

1986 • 23 citations

Reversible uncoupling of oxidative phosphorylation at low oxygen tension.

1983 • 22 citations

Decreased intracellular glutathione concentration and increased hyperthermic cytotoxicity in an acid environment.

1985 • 22 citations

Synthesis of diadenosine‐5',5'''‐p¹,p³‐triphosphate in yeast at heat shock

1984 • 21 citations

Chromosomal puff induction in salivary glands from Drosophila hydei by arsenite

1977 • 19 citations

Induction of stress proteins in chicken embryo cells by low‐level zinc contamination in amino acid‐free media

1985 • 19 citations

Induction of thermotolerance and heat shock protein synthesis in normal and respiration-deficient chick embryo fibroblasts.

1985 • 18 citations

Reduction of rat thymocyte interphase death by hyperthermia.

1980 • 18 citations

Enhancement of heat sensitivity and modification of repair of potentially lethal heat damage in plateau-phase cultures of mammalian cells by diethyldithiocarbamate.

1983 • 18 citations

Polyamines: A Dual Role in the Modulation of Cellular Sensitivity to Heat

1982 • 17 citations

Cellular ATP Content of Heated Chinese Hamster Ovary Cells

1984 • 16 citations

Invitro synthesis of superoxide dismutases of rat liver

1985 • 15 citations

Hydrogen peroxide toxicity may be enhanced by heat shock gene induction in Drosophila

1986 • 15 citations

Enhancement of Heat Sensitivity and Modification of Repair of Potentially Lethal Heat Damage in Plateau-Phase Cultures of Mammalian Cells by Diethyldithiocarbamate

1983 • 14 citations

Induction of self-tolerance and enhanced stress protein synthesis in L-132 cells by cadmium chloride and by hyperthermia

1985 • 11 citations

Sensitization of Cultured Chinese Hamster Cells to 42°C Hyperthermia by Pentalenolactone, an Inhibitor of Glycolytic ATP Synthesis

1985 • 10 citations

Reduction of Rat Thymocyte Interphase Death by Hyperthermia

1980 • 10 citations

Influence of Hypoxia on the Development of Thermotolerance

1982 • 8 citations

Assessment of the Role of Oxygen and Mitochondria in Heat Shock Induction of Radiation and Thermal Resistance in Saccharomyces cerevisiae

1983 • 7 citations

Sensitization to Heat by the Polyamines and Their Analogs

1983 • 7 citations

Responses of Oxic and Hypoxic Human Colon Tumor Cells to Hyperthermia

1982 • 7 citations

Role of Tumor Cell Membrane in Hyperthermia

2019 • 5 citations

Heat Shock Proteins and Cell Thermotolerance

2019 • 5 citations

Effect of Hyperthermia on DNA Synthesis

2019 • 4 citations