Clock Genes in Cell Clocks: Roles, Actions, and Mysteries

Liver Regeneration

1997 • 2,731 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

2004 • 2,231 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

2000 • 1,733 citations

Suprachiasmatic nucleus : the mind's clock

1991 • 1,730 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Extensive and divergent circadian gene expression in liver and heart

2002 • 1,498 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

A retinohypothalamic projection in the rat

1972 • 1,255 citations

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

2002 • 1,216 citations

Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

2003 • 1,101 citations

Persistence of circadian rhythmicity in a mammalian hypothalamic "island" containing the suprachiasmatic nucleus.

1979 • 968 citations

The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila

1998 • 952 citations

Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

2003 • 910 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop

2002 • 748 citations

A Web of Circadian Pacemakers

2002 • 732 citations

Hypothalamic integration of central and peripheral clocks

2001 • 557 citations

Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

2001 • 551 citations

Molecular Mechanisms of the Biological Clock in Cultured Fibroblasts

2001 • 465 citations

Light acts directly on organs and cells in culture to set the vertebrate circadian clock

2000 • 448 citations

Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

2002 • 380 citations

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism

2001 • 374 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain

1998 • 305 citations

Adrenergic regulation of clock gene expression in mouse liver

2003 • 288 citations

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

2003 • 285 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

Instability of Hes7 protein is crucial for the somite segmentation clock

2004 • 246 citations

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT

1998 • 234 citations

Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster

2002 • 221 citations

Circadian Chronopharmacology

1971 • 221 citations

Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance

2002 • 179 citations

Light Regulates the Cell Cycle in Zebrafish

2003 • 176 citations

Regulation of hepatic growth

1986 • 173 citations

Posttranscriptional and Posttranslational Regulation of Clock Genes

2004 • 167 citations

Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

1999 • 163 citations

No Circadian Rhythms in Testis: Period1 Expression Is Clock Independent and Developmentally Regulated in the Mouse

2003 • 163 citations

Transcription Regulation within the Circadian Clock: The E-box and Beyond

2004 • 149 citations

Suprachiasmatic Nucleus Grafts Restore Circadian Behavioral Rhythms of Genetically Arrhythmic Mice

2003 • 145 citations

Non-cyclic and Developmental Stage-Specific Expression of Circadian Clock Proteins During Murine Spermatogenesis1

2003 • 137 citations

Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus

2004 • 135 citations

Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications

2000 • 102 citations

No Evidence for Extraocular Photoreceptors in the Circadian System of the Syrian Hamster

1999 • 100 citations

Clock Gene Evolution and Functional Divergence

2004 • 95 citations

Visualization of mPer1 transcription in vitro

2001 • 65 citations

Circadian rhythm of cell division

1996 • 48 citations

The effect of continuous light or darkness on the rhythm of the mitotic index in the corneal epithelium of the rat

1974 • 28 citations

Photooxidation and the evolution of circadian rhythmicity

1982 • 21 citations

Circadian system in the insect testes controls the rhythmic release of sperm.

1990 • 7 citations

Muscarinic sites in the amphibian central nervous system: characterization and temperature studies.

1980 • 7 citations