Bleomycin: A pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

A clinical review of bleomycin—a new antineoplastic agent

1973 • 860 citations

New antibiotics, bleomycin A and B.

1966 • 721 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Druginduced pulmonary disease. Part 1 : Cytotoxic drugs

1986 • 544 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse.

1979 • 425 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.

1979 • 306 citations

Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

1978 • 299 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Action of Bleomycin on DNA and RNA

1972 • 195 citations

Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice.

1976 • 194 citations

Bleomycin: Chemical, Biochemical, and Biological Aspects

1979 • 186 citations

The Role of Strain Variation in Murine Bleomycin-lnduced Pulmonary Fibrosis^1,2

1983 • 183 citations

STUDIES ON THE MECHANISM OF ANTITUMOR EFFECT OF BLEOMYCIN ON SQUAMOUS CELL CARCINOMA

1972 • 168 citations

Metabolism and action of anti-cancer drugs

1987 • 161 citations

High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis.

1987 • 141 citations

Bleomycin-induced interstitial pneumonia in dogs

1971 • 136 citations

Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.

1983 • 133 citations

Profiles of steady state levels of messenger RNAs coding for type I procollagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis.

1985 • 131 citations

Increased elastin and collagen content in the lungs of hamsters receiving an intratracheal injection of bleomycin.

1978 • 122 citations

Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs.

1986 • 116 citations

Bleomycin-Induced Diffuse Interstitial Pulmonary Fibrosis in Baboons

1978 • 110 citations

Pulmonary toxicity of bleomycin.

1976 • 105 citations

Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family

1989 • 102 citations

Sequence-Specific Isotope Effects on the Cleavage of DNA by Bleomycin

1989 • 101 citations

Role of single-breath carbon monoxide-diffusing capacity in monitoring the pulmonary effects of bleomycin in germ cell tumor patients.

1979 • 97 citations

Bleomycin-induced pulmonary fibrosis. Effects of steroid on lung collagen metabolism.

1981 • 95 citations

Effect of Murine Gamma Interferon on the Cellular Responses to Bleomycin in Mice

1988 • 90 citations

Bleomycin Chemotherapy

1985 • 89 citations

Pulmonary toxicity after radiation and bleomycin: A review

1979 • 86 citations

Effects of oxygen on the newborn.

1985 • 81 citations

High Levels of Transforming Growth Factor-β Are Present in the Epithelial Lining Fluid of the Normal Human Lower Respiratory Tract

1988 • 81 citations

Interstitial Lung Disease

1988 • 75 citations

Early Cellular Events in Pulmonary Fibrosis

1986 • 71 citations

Chronic Interstitial Pulmonary Fibrosis Produced in Hamsters by Endotracheal Bleomycin

2015 • 67 citations

Susceptibility to experimental interstitial lung disease is modified by immune- and non-immune-related genes.

1987 • 63 citations

Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells.

1984 • 61 citations

Acute pulmonary toxicity of bleomycin: DNA scission and matrix protein mRNA levels in bleomycin-sensitive and -resistant strains of mice.

1989 • 57 citations

Bronchoalveolar Lavage Procoagulant Activity in Bleomycin-Induced Lung Injury in Marmosets: Characterization and Relationship to Fibrin Deposition and Fibrosis

1987 • 55 citations

Augmentation of fibroblast proliferation by bleomycin.

1986 • 55 citations

The Effect of Deferoxamine on Bleomycin-induced Lung Fibrosis in the Hamster

1985 • 53 citations

Bleomycin selectively elevates mRNA levels for procollagen and fibronectin following acute lung injury

1985 • 52 citations

Intratracheal versus intravenous administration of bleomycin in mice: Acute effects*1

1986 • 50 citations

Evaluation of antifibrotic drugs in bleomycin-induced pulmonary fibrosis in hamsters.

1980 • 49 citations

Routine Pulmonary Function Tests During Bleomycin Therapy

1980 • 48 citations

Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase

1987 • 45 citations

Lipid peroxidation by bleomycin-iron complexes in vitro.

1985 • 43 citations

Bleomycin hydrolase activity in pulmonary cells.

1984 • 43 citations

Early increases in pulmonary mRNA encoding procollagens and transforming growth factor-beta in mice sensitive to cyclophosphamide-induced pulmonary fibrosis.

1989 • 41 citations

Pulmonary fate of [3H]bleomycin A2 in mice.

1984 • 39 citations

Reduction in rabbit serum and pulmonary angiotensin converting enzyme activity after subacute bleomycin treatment

1981 • 38 citations

Radioautographic studies on the intracellular distribution of bleomycin-14C in mouse tumor cells.

1974 • 38 citations

Plasma and pulmonary pharmacokinetics of bleomycin in murine strains that are sensitive and resistant to bleomycin-induced pulmonary fibrosis.

1988 • 37 citations

Bleomycin treatment of chick fibroblasts causes an increase of polysomal type I procollagen mRNAs. Reversal of the bleomycin effect by dexamethasone.

1983 • 37 citations

Ferric bleomycin catalyzed reduction of 10-hydroperoxy-8,12-octadecadienoic acid: evidence for homolytic oxygen-oxygen bond scission

1988 • 35 citations

Biochemical indices of cyclophosphamide-induced lung toxicity

1984 • 35 citations

beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster.

1982 • 34 citations

Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline.

1981 • 33 citations

Intra-alveolar Release of a Competence-type Growth Factor after Lung Injury^1–3

1986 • 33 citations

Anticancer Drug Resistance

1994 • 32 citations

Assessment of preferential cleavage of an actively transcribed retroviral hybrid gene in murine cells by deoxyribonuclease I, bleomycin, neocarzinostatin, or ionizing radiation

1987 • 31 citations

Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin.

1989 • 30 citations

Role of DNA topology in altering the site/sequence specificity of cleavage of DNA by bleomycin and talisomycin

1983 • 30 citations

Advances in Bleomycin Studies

1979 • 30 citations

Phenotypic plasticity of extracellular matrix gene expression in cultured hamster lung fibroblasts. Regulation of type I procollagen and fibronectin synthesis.

1987 • 26 citations

Studies on the interaction of bleomycin A2 with rat lung microsomes. I. Characterization of factors which influence bleomycin-mediated DNA chain breakage.

1982 • 26 citations

Ameliorating effect of an interferon inducer polyinosinic-polycytidylic acid on bleomycin-induced lung fibrosis in hamsters. Morphologic and biochemical evidence.

1988 • 26 citations

Metabolic inactivation of bleomycin analogs by bleomycin hydrolase

1988 • 25 citations

Angiotensin converting enzyme activity in mice after subacute bleomycin administration

1981 • 24 citations

Bleomycin Induces the hsp 70 Heat Shock Promoter in Cultured Cells

1989 • 24 citations

The role of soluble factors in bleomycin-induced pulmonary fibrosis.

1982 • 22 citations

Biosynthesis of interstitial and basement membrane collagens in pulmonary fibrosis.

1986 • 21 citations

Bleomycin hydrolase is a unique thiol aminopeptidase

1989 • 19 citations

Deferoxamine Infusion Does Not Inhibit Bleomycin-induced Lung Damage in the Rat

1988 • 18 citations

Different Sensitivity to Bleomycin-Induced Pulmonary Fibrosis among Various Strains of Mice

1987 • 18 citations

Bleomycin inhibition of angiotensin-converting enzyme activity from serum, lungs, and cultured pulmonary artery endothelial cells.

1986 • 17 citations

Ultrastructural study of the effect of bleomycin A2 on the nucleolus and its possibly related cytoplasmic constituents in Novikoff hepatoma cells.

1975 • 16 citations

The effects of prior exposure to bleomycin on the incidence of pulmonary toxicities in a group of patients with disseminated testicular carcinomas

1978 • 15 citations

The effect of cyclosporin A on pulmonary fibrosis induced by butylated hydroxytoluene, bleomycin and beryllium sulfate

1985 • 15 citations

Biosynthesis of Collagen Crosslinks. III. In Vivo Labeling and Stability of Lung Collagen in Rats with Bleomycin-induced Pulmonary Fibrosis

1989 • 15 citations

Peplomycin and liblomycin, a new analogues of bleomycin.

1987 • 10 citations

Effect of intratracheally administered anticancer drugs on lung hydroxyproline content

1986 • 10 citations

The effect of endotoxin on bleomycin-induced lung fibrosis in the rat

1985 • 10 citations

Metabolism of bleomycin and bleomycin like compounds

1987 • 10 citations

The crypto-OH· radical in the damage of dna by bleomycin-Fe2+?

1982 • 8 citations

Routine pulmonary function tests during bleomycin therapy. Tests may be ineffective and potentially misleading

1980 • 3 citations

Deleted Work

1955 • 0 citations