Effects of Site-directed Mutations on the Chaperone-like Activity of αB-Crystallin

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Alpha-crystallin can function as a molecular chaperone.

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Short-range order of crystallin proteins accounts for eye lens transparency

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1989 • 703 citations

αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain

1989 • 546 citations

Alpha B-crystallin is a small heat shock protein.

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1995 • 278 citations

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1992 • 187 citations

Interaction of .alpha.-crystallin with Spin-Labeled Peptides

1995 • 185 citations

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1988 • 177 citations

αB-Crystallin is present in reactive glia in Creutzfeldt-Jakob disease

1992 • 165 citations

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1991 • 163 citations

Catalysis of Amide Proton Exchange by the Molecular Chaperones GroEL and SecB

1996 • 134 citations

Evidence that α-crystallin prevents non-specific protein aggregation in the intact eye lens

1995 • 128 citations

The C-terminal region of α-crystallin: involvement in protection against heat-induced denaturation

1993 • 118 citations

On the interaction of α-crystallin with unfolded proteins

1995 • 102 citations

Sense and antisense modification of glial alpha B-crystallin production results in alterations of stress fiber formation and thermoresistance.

1994 • 97 citations

αB Crystallin Accumulation Is a Specific Response to Ha-ras and v-mos Oncogene Expression in Mouse NIH 3T3 Fibroblasts

1991 • 95 citations

Characterization of the α-γ and α-β Complex: Evidence for an In Vivo Functional Role of α-Crystallin as a Molecular Chaperone

1994 • 80 citations

Low apparent aldose reductase activity produced by monosaccharide autoxidation

1985 • 61 citations

The Mutation Asp69→Ser Affects the Chaperone‐Like Activity of αA‐Crystallin

1995 • 59 citations

Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.

1991 • 50 citations

Interaction of ATP and lens alpha crystallin characterized by equilibrium binding studies and intrinsic tryptophan fluorescence spectroscopy

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Post-translational Modifications of Proteins

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1995 • 15 citations

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Heterologous expression in Escherichia coli of native and mutant forms of the major intrinsic protein of rat eye lens (MIP26)

1995 • 8 citations

A High-Yield Modification of Mutation by Overlap Extension Using Three Primers

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Heterologous Expression of γE-Crystallin Produces Protein with an Aberrant Tertiary Structure

1994 • 5 citations

On the stability of bovine gamma II crystallin

1992 • 4 citations