Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections

1989 • 2,357 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex.

1991 • 628 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

1989 • 318 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Techniques in HIV Research

1990 • 263 citations

Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine.

1992 • 240 citations

Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals

1989 • 225 citations

CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. Evidence for a soluble inhibitor.

1990 • 196 citations

Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.

1993 • 196 citations

CD8⁺Cell Anti-HIV Activity: Nonlytic Suppression of Virus Replication

1992 • 194 citations

A Single Amino Acid Interchange Yields Reciprocal CTL Specificities for HIV-1 gp160

1989 • 181 citations

Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope.

1994 • 179 citations

Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals.

1991 • 150 citations

Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.

1992 • 139 citations

Induction of Broadly Cross-Reactive Cytotoxic T Cells Recognizing an HIV-1 Envelope Determinant

1992 • 139 citations

Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual.

1988 • 129 citations

Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone

1993 • 112 citations

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals

1990 • 110 citations

An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself.

1990 • 110 citations

Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types.

1991 • 100 citations

Comparative clonal analysis of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ and CD8+ cytolytic T lymphocytes isolated from seronegative humans immunized with candidate HIV-1 vaccines.

1992 • 94 citations

Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.

1991 • 85 citations

Interference with human immunodeficiency virus (HIV) replication by CD8+ T cells in peripheral blood leukocytes of asymptomatic HIV carriers in vitro

1990 • 76 citations

T cell multideterminant regions in the human immunodeficiency virus envelope: toward overcoming the problem of major histocompatibility complex restriction

1989 • 75 citations

Neutralization of multiple laboratory and clinical isolates of human immunodeficiency virus type 1 (HIV-1) by antisera raised against gp120 from the MN isolate of HIV-1

1992 • 74 citations

Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine

1994 • 66 citations

Induction of HIV-Specific CTL and Antibody Responses in Mice Using Retroviral Vector-Transduced Cells

1991 • 45 citations

Virus Isolation and Production

1990 • 42 citations

Induction of Antigen-Specific Killer T Lymphocyte Responses Using Subunit SIV_mac251gagandenvVaccines Containing QS-21 Saponin Adjuvant

1994 • 42 citations

Expression and immunogenicity of the extracellular domain of the human immunodeficiency virus type 1 envelope glycoprotein, gp160

1989 • 42 citations

Effects of GLQ223™ on HIV Replication in Human Monocyte/Macrophages Chronically Infected In Vitro with HIV

1990 • 40 citations

Persisting Human Immunodeficiency Virus Type 1 gp160-Specific Human T Lymphocyte Responses Including CD8+ Cytotoxic Activity after Receipt of Envelope Vaccines

1993 • 40 citations

Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Infection: Responses to Structural Proteins

1994 • 37 citations

Cross-reactive lysis of human targets infected with prototypic and clinical human immunodeficiency virus type 1 (HIV-1) strains by murine anti-HIV-1 IIIB env-specific cytotoxic T lymphocytes

1993 • 32 citations

Cytotoxic T Lymphocytes Specific for HIV-1 gp160 Antigen and Synthetic P18III_BPeptide in an HLA-A11-Immunized Individual

1994 • 22 citations

Strain Specificity of Cell-Mediated Cytotoxic Responses Specific for the Human Immunodeficiency Virus Type 1 (HIV-1) Envelope Protein in Seropositive Donors: HIV-1Lai Is More Commonly Recognized than HIV-1MN

1994 • 7 citations

Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.

1994 • 7 citations

Use of fixed autologous stimulator cells to correctly present human immunodeficiency virus type 1 viral peptides to nonhuman primate lymphocytes in proliferation and cytotoxic T-lymphocyte assays

1994 • 7 citations

Implications of HIV specific cytotoxic T lymphocytes in AIDS

1992 • 5 citations

Systematic identification of T-cell activating epitopes on the human immunodeficiency virus type 1 envelope glycoprotein gp120 in primates immunized with synthetic peptides

1993 • 3 citations