Implications of HIV specific cytotoxic T lymphocytes in AIDS

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

Transfer of a functional human immune system to mice with severe combined immunodeficiency

1988 • 1,248 citations

Nucleotide sequence of the AIDS virus, LAV

1985 • 1,225 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.

1983 • 852 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)

1985 • 718 citations

Biologic Features of HIV-1 That Correlate with Virulence in the Host

1988 • 679 citations

Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III

1985 • 629 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.

1988 • 462 citations

Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

1988 • 462 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

A Formalin-Inactivated Whole SIV Vaccine Confers Protection in Macaques

1989 • 419 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Specificity of Virus‐Immune Effector T Cells for H‐2K or H‐2D Compatible Interactions: Implications for H‐Antigen Diversity

1976 • 385 citations

Infection and Replication of HIV-1 in Purified Progenitor Cells of Normal Human Bone Marrow

1988 • 375 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Infection of the SCID-hu Mouse by HIV-1

1988 • 368 citations

ANTIBODY-DEPENDENT ENHANCEMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION

1988 • 362 citations

Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS

1984 • 325 citations

Vaccine protection against simian immunodeficiency virus infection.

1989 • 324 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.

1989 • 318 citations

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.

1981 • 317 citations

T cells can present antigens such as HIV gp120 targeted to their own surface molecules

1988 • 294 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

1989 • 241 citations

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

1986 • 240 citations

Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

1987 • 226 citations

Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees

1987 • 197 citations

Incubation periods for paediatric AIDS patients

1988 • 196 citations

Expression of AIDS virus envelope gene in recombinant vaccinia viruses

1986 • 192 citations

A group specific anamnestic immune reaction against HIV-1 induced by a candidate vaccine against AIDS

1988 • 183 citations

Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.

1988 • 157 citations

Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins

1989 • 152 citations

T cell receptor gamma/delta+ lymphocyte subsets during HIV infection.

1989 • 148 citations

T-Lymphocyte Priming and Protection Against Friend Leukemia by Vaccinia-RetrovirusenvGene Recombinant

1986 • 141 citations

Human Immunodeficiency Virus-related Lymphocytic Alveolitis

1988 • 130 citations

Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones

1988 • 129 citations

Group-specific, major histocompatibility complex class I-restricted cytotoxic responses to human immunodeficiency virus 1 (HIV-1) envelope proteins by cloned peripheral blood T cells from an HIV-1-infected individual.

1988 • 129 citations

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89

1988 • 128 citations

Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes.

1989 • 124 citations

Immunology of Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome

1987 • 122 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS

1988 • 119 citations

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.

1988 • 117 citations

INTERACTIONS BETWEEN HOST AND VIRAL GENOMES IN MOUSE LEUKEMIA

1977 • 109 citations

Human immunodeficiency virus type 1 (HIV-1) infection of the nervous system: a review.

1988 • 109 citations

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.

1980 • 100 citations

AIDS virus env Protein Expressed from a Recombinant Vaccinia Virus

1986 • 97 citations

Evidence for a cytotoxic T-lymphocyte alveolitis in human immunodeficiency virus-infected patients.

1988 • 96 citations

An antigenic peptide of the HIV‐1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA‐B

1989 • 91 citations

The gag-specific cytotoxic T lymphocytes in rhesus monkeys infected with the simian immunodeficiency virus of macaques.

1990 • 87 citations

Retrovirus antigens recognized by cytolytic T lymphocytes activate tumor rejection in vivo

1987 • 85 citations

Superinfection of a chimpanzee with a second strain of human immunodeficiency virus

1987 • 82 citations

T‐immunogenic peptides are constituted of rare sequence patterns. Use in the identification of T epitopes in the human immunodeficiency virus gag protein

1988 • 73 citations

Immunohistochemical, electron microscopic and in situ hybridization evidence for the involvement of lymphatics in the spread of HIV-1

1988 • 70 citations

T cell-mediated immunity to oncornavirus-induced tumors. II. Ability of different T cell sets to prevent tumor growth in vivo.

1980 • 63 citations

Effects and virulences of recombinant vaccinia viruses derived from attenuated strains that express the human T-cell leukemia virus type I envelope gene

1988 • 62 citations

Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes.

1988 • 60 citations

Functional activity in vivo of effector T cell populations. II. Anti-tumor activity exhibited by syngeneic anti-MoMULV-specific cytolytic T cell clones.

1984 • 53 citations

Friend virus-specific cytotoxic T lymphocytes recognize both gag and env gene-encoded specificities.

1986 • 53 citations

Detection of primary cytotoxic T lymphocytes specific for the envelope glycoprotein of HIV‐1 by deletion of the env amino‐terminal signal sequence

1990 • 49 citations

Immune recognition of AIDS virus antigens by human and murine cytotoxic T lymphocytes.

1988 • 46 citations

Multiple subsets of HIV‐specific cytotoxic T lymphocytes in humans and in mice

1989 • 44 citations

Epstein-Barr virus-specific cytotoxic T lymphocytes as probes of HLA polymorphism. Heterogeneity of T cell-restricting determinants associated with the serologically defined HLA-A2 antigen.

1983 • 42 citations

Impaired T-lymphocyte-dependent immune responses to microbial antigens in patients with HIV-1-associated persistent generalized lymphadenopathy

1988 • 40 citations

Enhancement of tumor growth correlates with suppression of the tumor-specific cytolytic T lymphocyte response in mice chronically infected by Trypanosoma cruzi.

1985 • 37 citations

Human allospecific cytolytic T lymphocyte lysis of a murine cell transfected with HLA-A2.

1987 • 35 citations

Human T cell recognition of cloned HL A class I gene products expressed on DNA transfectants of mouse mastocytoma P815

1985 • 34 citations

Cloned cytotoxic T lymphocytes recognize cells expressing discrete fragments of the SV40 tumor antigen.

1984 • 33 citations

Infection of B lymphocytes by the human immunodeficiency virus and their susceptibility to cytotoxic cells

1988 • 32 citations

CLINICAL AND IMMUNOLOGICAL RESTORATION IN PATIENTS WITH AIDS AFTER MARROW TRANSPLANTATION, USING LYMPHOCYTE TRANSFUSIONS FROM THE MARROW DONOR

1987 • 32 citations

Virus-triggered AIDS: a T-cell-mediated immunopathology?

1988 • 32 citations

The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens.

1985 • 29 citations

Antigen-specific primary cytotoxic T lymphocyte (CTL) responses in acquired immune deficiency syndrome (AIDS) and AIDS-related complexes (ARC).

1985 • 27 citations

HLA-B27, A dominant restricting element in antiviral responses?

1984 • 25 citations

Factors affecting the natural history of human immunodeficiency virus infection.

1988 • 25 citations

HIV‐specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus

1988 • 22 citations

H-2-restricted cytolysis of L cells doubly transformed with a cloned H-2Kb gene and cloned retroviral DNA.

1985 • 17 citations

Tumors induced by murine sarcoma virus contain precursor cells capable of generating tumor-specific cytolytic T lymphocytes.

1979 • 17 citations

Cytotoxic Capabilities of Lymphocytes from Patients with the Acquired Immunodeficiency Syndrome

1985 • 15 citations

AIDS as a consequence of la antigen recognition: a closer look

1986 • 11 citations

CD4+ proliferative T-cell clones reactive to autologous Epstein-Barr virus-transformed B cells (EBV-LCL) can be restricted by HLA class I molecules

1988 • 5 citations

Why high levels of virus-specific CTL persist in HIV1-infected individuals

1989 • 3 citations