Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

The role of hepatocytes and oval cells in liver regeneration and repopulation

2002 • 639 citations

The Liver: Biology and Pathobiology

1995 • 629 citations

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

2002 • 500 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Oval Cell Numbers in Human Chronic Liver Diseases Are Directly Related to Disease Severity

1999 • 445 citations

Oxidative Stress and Oval Cell Accumulation in Mice and Humans with Alcoholic and Nonalcoholic Fatty Liver Disease

2003 • 435 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Hepatic stem cells in liver regeneration

1996 • 308 citations

Is there a liver stem cell?

1990 • 304 citations

Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man

1998 • 288 citations

Origin and Structural Evolution of the Early Proliferating Oval Cells in Rat Liver

2001 • 284 citations

Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway

2000 • 256 citations

Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration.

1993 • 246 citations

Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells

2003 • 197 citations

Occurrence of oval-type cells in hepatitis B virus—associated human hepatocarcinogenesis

1992 • 195 citations

High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease

2003 • 192 citations

Hepatic progenitor cells in human liver diseases

2002 • 191 citations

Deep intralobular extension of human hepatic ?progenitor cells? correlates with parenchymal inflammation in chronic viral hepatitis: can ?progenitor cells? migrate?

2000 • 189 citations

Role of cholangioles in restoration of the liver of the mouse after dietary injury

1958 • 185 citations

CELL TYPES IN LONG‐TERM PROPAGABLE CULTURES OF RAT LIVER*

1980 • 180 citations

Neuroendocrine features of reactive bile ductules in cholestatic liver disease.

1990 • 165 citations

Ductular reaction and its diagnostic significance.

1998 • 163 citations

The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells

2000 • 161 citations

THE PATHOGENESIS OF TUMORS OF THE LIVER PRODUCED BY BUTTER YELLOW

1944 • 158 citations

Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light- and electron-microscopic analysis.

1987 • 143 citations

Promotion of growth and differentiation of rat ductular oval cells in primary culture.

1988 • 142 citations

Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury

1998 • 138 citations

Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6.

1998 • 135 citations

Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytesin vivo in the rat liver

1997 • 132 citations

Morphologic identification by electron microscopy of "oval" cells in experimental hepatic degeneration.

1961 • 131 citations

A cytokeratin immunohistochemical study of cholestatic liver disease: Evidence that hepatocytes can express “bile duct‐type” cytokeratins

1989 • 128 citations

Hepatic Progenitor Cells in Hepatocellular Adenomas

2001 • 125 citations

Hepatocyte differentiation and liver progenitor cells

1990 • 125 citations

Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes.

1996 • 124 citations

Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction.

1992 • 122 citations

Hepatic stem cells

1998 • 118 citations

‘Undifferentiated progenitor cells’ in focal nodular hyperplasia of the liver

1996 • 113 citations

Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.

1989 • 111 citations

Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non‐cirrhotic and cirrhotic chronic viral hepatitis

2001 • 109 citations

Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.

1989 • 107 citations

Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene.

1985 • 101 citations

Liver stem cells: a two compartment system

1998 • 99 citations

Identification of bipotential progenitor cells in human liver regeneration.

1996 • 98 citations

Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver.

1983 • 98 citations

Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells.

1992 • 93 citations

Update on hepatic stem cells

2001 • 82 citations

Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-fluorenylacetamide or ethionine in a choline-deficient diet.

1985 • 81 citations

Wound healing in the liver with particular reference to stem cells

1998 • 78 citations

Precursor-product relationship between oval cells and hepatocytes: comparison between tritiated thymidine and bromodeoxyuridine as tracers

1996 • 74 citations

Differential cytokeratin and alpha-fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis.

1985 • 72 citations

Models for Hepatic Progenitor Cell Activation

1993 • 68 citations

Sequential Observation of Liver Cell Regeneration after Massive Hepatic Necrosis in Auxiliary Partial Orthotopic Liver Transplantation

2000 • 67 citations

Bile duct changes in alcoholic liver disease

1993 • 64 citations

Expression of cyclin-dependent kinase inhibitor p21 in human liver

1998 • 62 citations

Expression of neural cell adhesion molecule in human liver development and in congenital and acquired liver diseases

2001 • 62 citations

Small epithelial cells in human liver cirrhosis exhibit features of hepatic stem‐like cells: immunohistochemical, electron microscopic and immunoelectron microscopic findings

2003 • 62 citations

The role of progenitor cells in repair of liver injury and in liver transplantation

2001 • 60 citations

Cells with neuroendocrine features in regenerating human liver.

1991 • 55 citations

Destruction of canals of hering in primary biliary cirrhosis

2002 • 51 citations

Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver

1997 • 47 citations

Cells with neuroendocrine features in regenerating human liver

1991 • 46 citations

Liver Damage using Suicide Genes

2000 • 38 citations

Small epithelial cells in extrahepatic biliary atresia: electron microscopic and immunoelectron microscopic findings suggest a close relationship to liver progenitor cells

1999 • 37 citations

AFP‐PRODUCING CELLS IN HEPATITIS AND IN LIVER CIRRHOSIS

1975 • 36 citations

Inhibition ofin vivorat liver regeneration by 2-acetylaminofluorene affects the regulation of cell cycle-related proteins

1998 • 31 citations

Effect of Acute and Chronic Ethanol Intoxication on Hepatic Regeneration

1980 • 19 citations

Neoductular progenitor cells regenerate hepatocytes in severely damaged liver: a comparative ultrastructural study

2002 • 10 citations

The carcinogen 2-acetylaminofluorene inhibits activation and nuclear accumulation of cyclin-dependent kinase 2 in growth-induced rat liver

2000 • 10 citations

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