Liver Damage using Suicide Genes

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

ON THE HISTOCHEMICAL DEMONSTRATION OF GLUCOSE-6-PHOSPHATASE

1956 • 381 citations

Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.

1994 • 378 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Is there a liver stem cell?

1990 • 304 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

The met Proto-Oncogene Receptor and Lumen Formation

1992 • 246 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse.

1994 • 168 citations

Transforming growth factor ? and tumor necrosis factor ? inhibit both apoptosis and proliferation of activated rat hepatic stellate cells

1999 • 162 citations

Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration

1998 • 154 citations

Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytesin vivo in the rat liver

1997 • 132 citations

Hepatocyte differentiation and liver progenitor cells

1990 • 125 citations

The extracellular matrix in hepatic regeneration. Localization of collagen types I, III, IV, laminin, and fibronectin.

1991 • 121 citations

Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase

1995 • 91 citations

Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells

1998 • 89 citations

Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

1991 • 87 citations

Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma

1999 • 83 citations

In vivo infusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2-acetylaminofluorene

1996 • 81 citations

Gene Transfer and Therapy with Adenoviral Vector in Rats with Diethylnitrosamine-Induced Hepatocellular Carcinoma

1997 • 75 citations

Coexpression of Stem Cell Factor andc-kitin Embryonic and Adult Liver

1996 • 75 citations

"Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan.

1993 • 72 citations

Significance of intestinal metaplasia for the evolution of cancer in the biliary tract

1984 • 71 citations

Blast-like cell compartment in carcinogen-induced proliferating bile ductules.

1996 • 70 citations

Role of TGF‐Beta in Normal Differentiation and Oncogenesis in Rat Liver

1989 • 61 citations

Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver

1993 • 52 citations

Biliary Proliferation and Adaptation in Furan-Induced Rat Liver Injury and Carcinogenesis

1996 • 49 citations

Ductular hepatocytes. Evidence for a bile ductular cell origin in furan-treated rats.

1994 • 48 citations

Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver

1997 • 47 citations

Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma

1997 • 46 citations

Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated “intestinal-type” biliary cancer chemically induced in rat liver

2000 • 44 citations

A unique rat model of bile ductular hyperplasia in which liver is almost totally replaced with well-differentiated bile ductules.

1994 • 38 citations

Phenotypic Heterogeneity within Clonogenic Ductal Cell Populations Isolated from Normal Adult Rat Liver

1993 • 32 citations

Characterization of a mature bile duct antigen expressed on a subpopulation of biliary ductular cells but absent from oval cells

1993 • 27 citations

Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma

1996 • 17 citations

Prolonged oval cell proliferation with Ito cell activation and extracellular matrix accumulation in galactosamine-induced acute hepatitis in mini rats.

1997 • 12 citations