Inhibition ofin vivorat liver regeneration by 2-acetylaminofluorene affects the regulation of cell cycle-related proteins

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Mammalian G1 cyclins

1993 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1995 • 552 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.

1994 • 363 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

Cyclins and oncogenesis

1993 • 199 citations

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

1995 • 162 citations

Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration.

1994 • 135 citations

A Simplified Method for the Preparation of Transcriptionally Active Liver Nuclear Extracts

1990 • 134 citations

P21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation

1996 • 132 citations

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

1992 • 131 citations

Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect

1983 • 85 citations

Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol

1994 • 63 citations

Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate

1992 • 62 citations

Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis.

1982 • 55 citations

ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoter

1996 • 52 citations

Expression of the c-myc, c-fos and c-ras_Ha protooncogenes during sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model

1989 • 30 citations

Characterization of mutations induced by 2-(N-acetoxy-N-acetyl)aminofluorene in the dihydrofolate reductase gene of cultured hamster cells.

1986 • 27 citations

Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules

1993 • 24 citations

Sex-differentiated and growth-hormone-regulated mitoinhibition in rat liver during treatment with 2-acetylaminofluorene and partial hepatectomy in the resistant hepatocyte model

1991 • 22 citations

The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo

1989 • 18 citations

Loss of sexual differentiation of metabolism of steroids and xenobiotics in nodular hepatic hepatic tissue from male and female Wistar rats treated according to the resistant hepatocyte model

1990 • 6 citations

Ribonucleotide reductase: a possible target for orotic acid induced mitoinhibition in normal hepatocytes in primary culture

1993 • 6 citations