Id proteins in cell growth and tumorigenesis

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 • 919 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis

2000 • 671 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

2001 • 627 citations

Transcriptional profiling identifies Id2 function in dendritic cell development

2003 • 513 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

Id helix—loop—helix proteins in cell growth and differentiation

1998 • 413 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Regulation of the Expression of Cyclin-Dependent Kinase Inhibitor p21 by E2A and Id Proteins

1997 • 326 citations

Id proteins in cell cycle control and cellular senescence

2001 • 280 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Id proteins at the cross-road of development and cancer

2001 • 255 citations

High Incidence of T-Cell Tumors in E2A-Null Mice and E2A/Id1 Double-Knockout Mice

1997 • 238 citations

A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.

2000 • 237 citations

Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a

2001 • 222 citations

Thymocyte Selection Is Regulated by the Helix-Loop-Helix Inhibitor Protein, Id3

2000 • 220 citations

Id and development

2001 • 208 citations

Suppression of Mammary Epithelial Cell Differentiation by the Helix-Loop-Helix Protein Id-1

1995 • 189 citations

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

2002 • 184 citations

Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β

2001 • 166 citations

Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer.

2001 • 163 citations

Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene

1999 • 163 citations

Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC.

2001 • 159 citations

Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis

1999 • 154 citations

A Novel Pathway for Mammary Epithelial Cell Invasion Induced by the Helix-Loop-Helix Protein Id-1

1998 • 150 citations

Overexpression of Id‐1 is associated with poor clinical outcome in node negative breast cancer

2003 • 143 citations

Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages

1999 • 141 citations

Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors.

2003 • 138 citations

Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma.

2002 • 137 citations

Immortalization of primary human keratinocytes by the helix–loop–helix protein, Id-1

1999 • 137 citations

Id-1 Delays Senescence but Does Not Immortalize Keratinocytes

2000 • 133 citations

Over Expression of ID-1 in Prostate Cancer

2002 • 133 citations

Massive Apoptosis of Thymocytes in T-Cell-Deficient Id1 Transgenic Mice

1999 • 133 citations

Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index.

2001 • 133 citations

Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors

1997 • 129 citations

Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

2003 • 122 citations

Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth.

2000 • 115 citations

Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma.

2000 • 114 citations

Expression and distribution of id helix‐loop‐helix proteins in human astrocytic tumors

2002 • 114 citations

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors

2002 • 106 citations

Regulation of Id3 Cell Cycle Function by Cdk-2-Dependent Phosphorylation

1997 • 103 citations

The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas.

2001 • 96 citations

Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis

2001 • 91 citations

Forced Expression of Id-1 in the Adult Mouse Small Intestinal Epithelium Is Associated with Development of Adenomas

1998 • 84 citations

Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function.

1998 • 82 citations

Id gene expression as a key mediator of tumor cell biology.

1999 • 77 citations

The Helix–Loop–Helix Protein Id-1 Delays Onset of Replicative Senescence in Human Endothelial Cells

2002 • 75 citations

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma

2001 • 69 citations

Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex

2002 • 65 citations

Expression of Id1 Results in Apoptosis of Cardiac Myocytes through a Redox-dependent Mechanism

1998 • 62 citations

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial Cells

2003 • 56 citations

Id4 Expression Induces Apoptosis in Astrocytic Cultures and Is Down-regulated by Activation of the cAMP-Dependent Signal Transduction Pathway

1999 • 54 citations

The helix-loop-helix transcription factor, Id-1, is overexpressed in medullary thyroid cancer

2000 • 51 citations

Emc, a negative HLH regulator with multiple functions in Drosophila development

2001 • 51 citations

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

2003 • 44 citations

Evidence of increased Id‐1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells

2002 • 33 citations

ID2 expression is not associated with MYCN amplification or expression in human neuroblastomas.

2003 • 29 citations

Expression of the Helix–Loop–Helix Protein ID1 in Keratinocytes Is Upregulated by Loss of Cell–Matrix Contact

2001 • 17 citations

Deleted Work

1955 • 0 citations