Structure and function of desmosomal proteins and their role in development and disease

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

2000 • 1,167 citations

Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)

2000 • 1,079 citations

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma

2000 • 777 citations

C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms

2002 • 663 citations

Mutation in Human Desmoplakin Domain Binding to Plakoglobin Causes a Dominant Form of Arrhythmogenic Right Ventricular Cardiomyopathy

2002 • 647 citations

Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

2000 • 535 citations

Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1

2000 • 472 citations

Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

1997 • 428 citations

The p120 catenin family: Complex roles in adhesion, signaling and cancer

2000 • 427 citations

Role of plectin in cytoskeleton organization and dynamics

1998 • 404 citations

Are desmosomes more than tethers for intermediate filaments?

2000 • 388 citations

Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome

1997 • 369 citations

Desmoplakin Is Required Early in Development for Assembly of Desmosomes and Cytoskeletal Linkage

1998 • 336 citations

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.

1996 • 335 citations

Embryonic Heart and Skin Defects in Mice Lacking Plakoglobin

1996 • 323 citations

Cadherins and tissue formation: integrating adhesion and signaling

1999 • 318 citations

Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture

1997 • 317 citations

Plakins: a family of versatile cytolinker proteins

2002 • 311 citations

Desmoplakin is essential in epidermal sheet formation

2001 • 304 citations

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.

1996 • 278 citations

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma [published erratum appears in Hum Mol Genet 1999 May;8(5):943]

1999 • 260 citations

Defining the Interactions Between Intermediate Filaments and Desmosomes

1998 • 257 citations

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus

2000 • 251 citations

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

2001 • 249 citations

The Armadillo Family of Structural Proteins

1998 • 246 citations

Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and Desmocollin, Contributes to Cell–Cell Adhesion

1997 • 242 citations

The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

1997 • 237 citations

Desmosomes: Intercellular Adhesive Junctions Specialized for Attachment of Intermediate Filaments

1998 • 234 citations

Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.

1996 • 227 citations

Protein Binding and Functional Characterization of Plakophilin 2

2002 • 223 citations

N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma

1999 • 221 citations

Multiple cadherin extracellular repeats mediate homophilic binding and adhesion

2001 • 219 citations

Molecular map of the desmosomal plaque

1999 • 214 citations

Periplakin, a Novel Component of Cornified Envelopes and Desmosomes That Belongs to the Plakin Family and Forms Complexes with Envoplakin

1997 • 206 citations

Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of α-Catenin from the E-Cadherin·Catenin Complex

1998 • 206 citations

Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1

2002 • 200 citations

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

2001 • 194 citations

A Central Role for the Armadillo Protein Plakoglobin in the Autoimmune Disease Pemphigus Vulgaris

2001 • 193 citations

Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein)

1995 • 190 citations

Desmosomal adhesion inhibits invasive behavior

1998 • 189 citations

Desmosomes and cytoskeletal architecture in epithelial differentiation: cell type-specific plaque components and intermediate filament anchorage.

1994 • 185 citations

Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature

2001 • 181 citations

Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage

1993 • 178 citations

Autoimmunity against desmosomal cadherins in pemphigus

1999 • 177 citations

The Function of Plakophilin 1 in Desmosome Assembly and Actin Filament Organization

2000 • 174 citations

Cadherin Function Is Required for Human Keratinocytes to Assemble Desmosomes and Stratify in Response to Calcium

1994 • 172 citations

Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components

1997 • 170 citations

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin.

1996 • 167 citations

Dominant Autoimmune Epitopes Recognized by Pemphigus Antibodies Map to the N-Terminal Adhesive Region of Desmogleins

2001 • 165 citations

The α Isoform of Protein Kinase C Is Involved in Signaling the Response of Desmosomes to Wounding in Cultured Epithelial Cells

2000 • 163 citations

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome

2002 • 161 citations

Desmoglein 3 anchors telogen hair in the follicle

1998 • 157 citations

Intermediate filament–membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength

2002 • 152 citations

Two-hybrid Analysis Reveals Fundamental Differences in Direct Interactions between Desmoplakin and Cell Type-specific Intermediate Filaments

1997 • 151 citations

Compound Heterozygosity for Non-Sense and Mis-Sense Mutations in Desmoplakin Underlies Skin Fragility/Woolly Hair Syndrome

2002 • 145 citations

Identification of Plakoglobin Domains Required for Association with N-cadherin and α-Catenin

1995 • 144 citations

Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation.

1996 • 144 citations

Homophilic adhesion by cadherins

1999 • 143 citations

The Head Domain of Plakophilin-1 Binds to Desmoplakin and Enhances Its Recruitment to Desmosomes

1999 • 142 citations

Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin.

1994 • 140 citations

Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins

1996 • 139 citations

Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules.

1995 • 135 citations

The Fate of Desmosomal Proteins in Apoptotic Cells

2001 • 134 citations

Direct Measurements of Multiple Adhesive Alignments and Unbinding Trajectories between Cadherin Extracellular Domains

2001 • 133 citations

Initiation of Assembly of the Cell Envelope Barrier Structure of Stratified Squamous Epithelia

1999 • 132 citations

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure

2002 • 131 citations

Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells

1999 • 130 citations

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

2000 • 130 citations

Desmoglein Isoform Distribution Affects Stratum Corneum Structure and Function

2001 • 129 citations

Protection against Pemphigus Foliaceus by Desmoglein 3 in Neonates

2000 • 126 citations

Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review)

2002 • 125 citations

Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks.

1994 • 124 citations

Desmosomal Cadherin Binding Domains of Plakoglobin

1996 • 122 citations

Immunolocalization of the intermediate filament-associated protein plectin at focal contacts and actin stress fibers.

1992 • 122 citations

Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion

1998 • 122 citations

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation

2002 • 118 citations

Plakophilin 3 – a novel cell-type-specific desmosomal plaque protein

1999 • 116 citations

Desmosomal localization of β-catenin in the skin of plakoglobin null-mutant mice

1999 • 114 citations

Roles of plakoglobin end domains in desmosome assembly

1997 • 114 citations

Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders

2001 • 114 citations

The Differential Fate of Cadherins during T-Cell-Induced Keratinocyte Apoptosis Leads to Spongiosis in Eczematous Dermatitis

2001 • 114 citations

Molecular interactions between desmosomal cadherins

2002 • 110 citations

Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle.

1995 • 109 citations

Transmembrane Signaling for Adhesive Regulation of Desmosomes and Hemidesmosomes, and for Cell-Cell Detachment Induced by Pemphigus IgG in Cultured Keratinocytes: Involvement of Protein Kinase C

1999 • 109 citations

Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: Identification of unique and shared domains

1996 • 108 citations

Plectin and human genetic disorders of the skin and muscle

1996 • 105 citations

Skin fragility and hypohidrotic ectodermal dysplasia resulting from ablation of plakophilin 1

1999 • 103 citations

Extracellular Domain of Pemphigus Vulgaris Antigen (Desmoglein 3) Mediates Weak Homophilic Adhesion

1994 • 103 citations

Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma

2001 • 102 citations

Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis.

1996 • 102 citations

IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions.

1994 • 92 citations

Analysis of Desmosomal Cadherin–Adhesive Function and Stoichiometry of Desmosomal Cadherin-Plakoglobin Complexes

1996 • 89 citations

Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover

2002 • 87 citations

The Expression of Desmoglein Isoforms in Cultured Human Keratinocytes Is Regulated by Calcium, Serum, and Protein Kinase C

1998 • 86 citations

Tyrosine-phosphorylated Plakoglobin Is Associated with Desmogleins but Not Desmoplakin after Epidermal Growth Factor Receptor Activation

2001 • 86 citations

Assembly Pathway of Desmoglein 3 to Desmosomes and Its Perturbation by Pemphigus Vulgaris-IgG in Cultured Keratinocytes, as Revealed by Time-Lapsed Labeling Immunoelectron Microscopy

2000 • 86 citations

Polycystin-1 Interacts with Intermediate Filaments

2001 • 85 citations

Binding of protein kinase B to the plakin family member periplakin

2002 • 82 citations

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis

2000 • 82 citations

Interaction of periplakin and envoplakin with intermediate filaments

2002 • 80 citations

Cadherin binding sites of plakoglobin: localization, specificity and role in targeting to adhering junctions

1996 • 78 citations

Genomic Amplification of the Human Plakophilin 1 Gene and Detection of a New Mutation in Ectodermal Dysplasia/Skin Fragility Syndrome

2000 • 76 citations

Aspects of the structure and assembly of desmosomes

1998 • 76 citations

Delayed Assembly of Desmosomes in Keratinocytes with Disrupted Classic-Cadherin-Mediated Cell Adhesion by a Dominant Negative Mutant

1995 • 74 citations

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion

2002 • 73 citations

Epithelial differentiation in the mouse preimplantation embryo: making adhesive cell contacts for the first time

1995 • 72 citations

Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains

2003 • 70 citations

Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin

2002 • 69 citations

Gene Targeting of Envoplakin, a Cytoskeletal Linker Protein and Precursor of the Epidermal Cornified Envelope

2001 • 68 citations

Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells

1998 • 65 citations

The Armadillo Family Protein p0071 Is a VE-cadherin- and Desmoplakin-binding Protein

2003 • 63 citations

Molecular organization of the desmoglein-plakoglobin complex

1998 • 63 citations

Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes

2000 • 58 citations

Immunopathology of paraneoplastic pemphigus

2001 • 58 citations

Molecular Diversity of Plaques of Epithelial‐Adhering Junctions

2000 • 56 citations

Assembly of Desmosomal Cadherins into Desmosomes is Isoform Dependent

2001 • 47 citations

Isolation of cDNAs encoding desmosomal plaque proteins: evidence that bovine desmoplakins I and II are derived from two mRNAs and a single gene.

1988 • 47 citations

Functional polycystin-1 expression is developmentally regulated during epithelial morphogenesis in vitro: downregulation and loss of membrane localization during cystogenesis

2002 • 45 citations

Central Role of the Plakoglobin-Binding Domain for Desmoglein 3 Incorporation into Desmosomes

2001 • 43 citations

The amino- and carboxyl-terminal tails of β-catenin reduce its affinity for desmoglein 2

2000 • 42 citations

Desmosome Assembly in MDCK Cells: Transport of Precursors to the Cell Surface Occurs by Two Phases of Vesicular Traffic and Involves Major Changes in Centrosome and Golgi Location during a Ca2+ Shift

2002 • 38 citations

Plakophilin, armadillo repeats, and nuclear localization

1999 • 36 citations

Clustered Cadherin Genes: A Sequence-Ready Contig for the Desmosomal Cadherin Locus on Human Chromosome 18

1999 • 36 citations

Trangenic Misexpression of the Differentiation-Specific Desmocollin Isoform 1 in Basal Keratinocytes

2001 • 29 citations

Involvement of Desmoplakin Phosphorylation in the Regulation of Desmosomes by Protein Kinase C, in HeLa Cells

1999 • 24 citations

Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression

1998 • 20 citations

Isoform-Specific Differences in the Size of Desmosomal Cadherin/Catenin Complexes

2001 • 19 citations

Postnatal Lethality of P-Cadherin/Desmoglein 3 Double Knockout Mice: Demonstration of a Cooperative Effect of these Cell Adhesion Molecules in Tissue Homeostasis of Stratified Squamous Epithelia

2000 • 19 citations

Physical characterization of plakophilin 1 reconstituted with and without zinc

2000 • 9 citations