Oral Anticoagulant Therapy

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

2009 • 10,717 citations

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

2011 • 8,749 citations

Hematological Problems in Pediatric Intensive Care

2013 • 3,403 citations

Oral Rivaroxaban for Symptomatic Venous Thromboembolism

2010 • 3,057 citations

Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

2009 • 2,469 citations

Pharmacology and Management of the Vitamin K Antagonists

2008 • 2,084 citations

Risk Factors for Stroke and Efficacy of Antithrombotic Therapy in Atrial Fibrillation

1994 • 1,970 citations

A Method to Determine the Optimal Intensity of Oral Anticoagulant Therapy

1993 • 1,962 citations

Summary of product characteristics

2013 • 1,917 citations

PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION

1989 • 1,845 citations

Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation

1999 • 1,655 citations

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

2009 • 1,526 citations

The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation

1990 • 1,503 citations

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty

2008 • 1,411 citations

Effect ofVKORC1Haplotypes on Transcriptional Regulation and Warfarin Dose

2005 • 1,397 citations

Dabigatran etexilate – a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity

2010 • 1,390 citations

Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT)

1996 • 1,331 citations

Effect of Intensity of Oral Anticoagulation on Stroke Severity and Mortality in Atrial Fibrillation

2003 • 1,281 citations

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Total Knee Arthroplasty

2008 • 1,271 citations

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1999 • 1,263 citations

Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone

1989 • 1,256 citations

Evidence-Based Management of Anticoagulant Therapy

2012 • 1,179 citations

Low-Dose Aspirin for the Prevention of Atherothrombosis

2005 • 1,162 citations

Canadian atrial fibrillation anticoaguiation (CAFA) study

1991 • 1,140 citations

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

2004 • 1,134 citations

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

1990 • 1,132 citations

Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial

2007 • 1,128 citations

Systematic Overview of Warfarin and Its Drug and Food Interactions

2005 • 1,122 citations

Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial

1996 • 1,088 citations

Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial

2008 • 1,069 citations

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

2002 • 1,052 citations

Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE‐MODEL randomized trial

2007 • 1,000 citations

Maternal and fetal sequelae of anticoagulation during pregnancy

1980 • 984 citations

Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial

2009 • 966 citations

Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (NRAF)

2006 • 956 citations

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

2005 • 946 citations

PSYCHOSOMATIC MEDICINE

1974 • 946 citations

Optimal Oral Anticoagulant Therapy in Patients with Mechanical Heart Valves

1995 • 931 citations

Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin

1994 • 926 citations

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

2007 • 893 citations

Benefit of Oral Anticoagulant Over Antiplatelet Therapy in Atrial Fibrillation Depends on the Quality of International Normalized Ratio Control Achieved by Centers and Countries as Measured by Time in Therapeutic Range

2008 • 858 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1998 • 820 citations

Long-Term, Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism

2003 • 818 citations

Risk of Bleeding With Single, Dual, or Triple Therapy With Warfarin, Aspirin, and Clopidogrel in Patients With Atrial Fibrillation

2010 • 817 citations

Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin

2008 • 805 citations

Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials

1994 • 794 citations

Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin ∗∗Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/

1998 • 789 citations

An Analysis of the Lowest Effective Intensity of Prophylactic Anticoagulation for Patients with Nonrheumatic Atrial Fibrillation

1996 • 780 citations

Antithrombotic Therapy in Atrial Fibrillation

2008 • 768 citations

Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk

1998 • 759 citations

Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis

1982 • 753 citations

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

1974 • 750 citations

Comparison of Low-Intensity Warfarin Therapy with Conventional-Intensity Warfarin Therapy for Long-Term Prevention of Recurrent Venous Thromboembolism

2003 • 735 citations

Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation

2007 • 731 citations

Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment

2008 • 726 citations

Influence of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate

2010 • 715 citations

Identification of the gene for vitamin K epoxide reductase

2004 • 710 citations

A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin

2004 • 708 citations

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

1993 • 682 citations

The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans

2007 • 676 citations

Drug Interactions with Tobacco Smoking

1999 • 653 citations

Oral Thrombin Inhibitor Dabigatran Etexilate vs North American Enoxaparin Regimen for Prevention of Venous Thromboembolism After Knee Arthroplasty Surgery

2008 • 641 citations

Clinical Pharmacokinetics and Pharmacodynamics of the Oral Direct Thrombin??Inhibitor Dabigatran Etexilate

2008 • 641 citations

Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939—an oral, direct Factor Xa inhibitor—after multiple dosing in healthy male subjects

2005 • 638 citations

Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939, an oral, direct factor Xa inhibitor

2005 • 625 citations

Comparison of an Anticoagulation Clinic With Usual Medical Care

1998 • 604 citations

In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939—an oral, direct Factor Xa inhibitor

2005 • 583 citations

Comparison of Outcomes Among Patients Randomized to Warfarin Therapy According to Anticoagulant Control

2007 • 572 citations

A Comparison of Aspirin with Placebo in Patients Treated with Warfarin after Heart-Valve Replacement

1993 • 563 citations

The Risk for and Severity of Bleeding Complications in Elderly Patients Treated with Warfarin

1996 • 559 citations

An analysis of the lowest effective intensity of prophylactic anticoagulation for patients with nonrheumatic atrial fibrillation

1997 • 556 citations

Bleeding complications in oral anticoagulant therapy. An analysis of risk factors

1993 • 553 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Effect of Study Setting on Anticoagulation Control

2006 • 495 citations

A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin

1997 • 478 citations

The Pathogenesis of Venous Limb Gangrene Associated with Heparin-Induced Thrombocytopenia

1997 • 478 citations

Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

2002 • 446 citations

Assessment of laboratory assays to measure rivaroxaban – an oral, direct factor Xa inhibitor

2010 • 440 citations

Self-monitoring of oral anticoagulation: a systematic review and meta-analysis

2006 • 439 citations

Dabigatran With or Without Concomitant Aspirin Compared With Warfarin Alone in Patients With Nonvalvular Atrial Fibrillation (PETRO Study)

2007 • 427 citations

Optimal Oral Anticoagulant Therapy in Patients with Nonrheumatic Atrial Fibrillation and Recent Cerebral Ischemia

1995 • 426 citations

Pharmacokinetics and Pharmacodynamics of the Direct Oral Thrombin Inhibitor Dabigatran in Healthy Elderly Subjects

2008 • 425 citations

Bleeding Complications in Oral Anticoagulant Therapy

1993 • 416 citations

Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II)

2011 • 397 citations

Acetaminophen and Other Risk Factors for Excessive Warfarin Anticoagulation

1998 • 389 citations

Pharmacokinetic and Pharmacodynamic Properties of Oral Anticoagulants, Especially Phenprocoumon

1999 • 387 citations

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1978 • 385 citations

Trial of Different Intensities of Anticoagulation in Patients with Prosthetic Heart Valves

1990 • 381 citations

CYP2C9 Genotype-guided Warfarin Prescribing Enhances the Efficacy and Safety of Anticoagulation: A Prospective Randomized Controlled Study

2007 • 367 citations

The vitamin K cycle

2005 • 364 citations

Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy

1997 • 364 citations

Role of prothrombin complex concentrates in reversing warfarin anticoagulation: A review of the literature

2007 • 364 citations

Bleeding during antithrombotic therapy in patients with atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators

1996 • 353 citations

Risk of Thromboembolism With Short-term Interruption of Warfarin Therapy

2008 • 347 citations

Effect of a Centralized Clinical Pharmacy Anticoagulation Service on the Outcomes of Anticoagulation Therapy

2005 • 345 citations

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance

2002 • 345 citations

Randomized Placebo-Controlled Study of Low-Dose Warfarin for the Prevention of Central Venous Catheter–Associated Thrombosis in Patients With Cancer

2005 • 332 citations

Oral Anticoagulant Therapy in Patients With Coronary Artery Disease: A Meta-analysis

1999 • 325 citations

RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT

1988 • 324 citations

Body Weight Has Limited Influence on the Safety, Tolerability, Pharmacokinetics, or Pharmacodynamics of Rivaroxaban (BAY 59‐7939) in Healthy Subjects

2007 • 324 citations

Trial of combined warfarin plus dipyridamole or aspirin therapy in prosthetic heart valve replacement: Danger of aspirin compared with dipyridamole

1983 • 311 citations

Hemorrhagic Complications of Anticoagulant Therapy

1974 • 310 citations

Fixed Minidose Warfarin and Aspirin Alone and in Combination vs Adjusted-Dose Warfarin for Stroke Prevention in Atrial Fibrillation

1998 • 305 citations

Calibration of Reference Thromboplastins and Standardisation of the Prothrombin Time Ratio

1983 • 301 citations

Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction

1997 • 301 citations

Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip Replacement

2005 • 291 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

Aspirin plus warfarin compared to aspirin alone after acute coronary syndromes: an updated and comprehensive meta-analysis of 25 307 patients

2005 • 286 citations

The Influence of Patient Adherence on Anticoagulation Control With Warfarin

2007 • 285 citations

Bleeding and Thromboembolism During Anticoagulant Therapy:A Population-Based Study in Rochester, Minnesota

1995 • 281 citations

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid.

1976 • 278 citations

Concise Review: Clinical Relevance of Drug–Drug and Herb–Drug Interactions Mediated by the ABC Transporter ABCB1 (MDR1, P-glycoprotein)

2007 • 277 citations

Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction

2004 • 273 citations

Population pharmacokinetics and pharmacodynamics of once and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement

2008 • 272 citations

Bleeding During Antithrombotic Therapy in Patients With Atrial Fibrillation

1996 • 270 citations

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1974 • 265 citations

Age as a determinant of sensitivity to warfarin.

1977 • 263 citations

Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty

2010 • 262 citations

VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation

2005 • 260 citations

Interindividual variability in sensitivity to warfarin-Nature or nurture?

2001 • 259 citations

Rivaroxaban: A New Oral Factor Xa Inhibitor

2010 • 256 citations

Effect of Food, an Antacid, and the H₂ Antagonist Ranitidine on the Absorption of BAY 59–7939 (Rivaroxaban), an Oral, Direct Factor Xa Inhibitor, in Healthy Subjects

2006 • 253 citations

Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects

2008 • 253 citations

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

2007 • 251 citations

Age and the Risk of Warfarin‐Associated Hemorrhage: The Anticoagulation and Risk Factors In Atrial Fibrillation Study

2006 • 242 citations

Aging and the Anticoagulant Response to Warfarin Therapy

1992 • 240 citations

Population Pharmacokinetics and Pharmacodynamics of Rivaroxaban – an Oral, Direct Factor Xa Inhibitor – in Patients Undergoing Major Orthopaedic Surgery

2008 • 239 citations

Vitamin K-dependent Proteins, Warfarin, and Vascular Calcification

2008 • 238 citations

Comparison of two levels of anticoagulant therapy in patients with substitute heart valves

1991 • 237 citations

Brief Communication: American Ginseng Reduces Warfarin's Effect in Healthy Patients

2004 • 236 citations

Warfarin Maintenance Dosing Patterns in Clinical Practice

2005 • 236 citations

Differentiation of metal ion-induced transitions of prothrombin fragment 1.

1977 • 235 citations

Multicentre randomised study of computerised anticoagulant dosage

1998 • 228 citations

Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

2005 • 226 citations

Comparison of Oral vs Intravenous Phytonadione (Vitamin K1) in Patients With Excessive Anticoagulation

2003 • 226 citations

Influence of CYP2C9 genotype on warfarin dose requirements—a systematic review and meta-analysis

2008 • 219 citations

Warfarin-Induced Skin Necrosis and Venous Limb Gangrene in the Setting of Heparin-Induced Thrombocytopenia

2004 • 219 citations

The Stereoselective Interaction of Warfarin and Metronidazole in Man

1976 • 216 citations

Studies on the optical enantiomorphs of warfarin in man

1974 • 215 citations

Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions

1989 • 212 citations

Comparison of 10-mg and 5-mg Warfarin Initiation Nomograms Together with Low-Molecular-Weight Heparin for Outpatient Treatment of Acute Venous Thromboembolism

2003 • 212 citations

Individual time within target range in patients treated with vitamin K antagonists: main determinant of quality of anticoagulation and predictor of clinical outcome. a retrospective study of 2300 consecutive patients with venous thromboembolism

2005 • 208 citations

Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I

2004 • 207 citations

Congenital malformations associated with the administration of oral anticoagulants during pregnancy

1975 • 205 citations

Interaction of Warfarin With Drugs, Natural Substances, and Foods

2005 • 203 citations

A Prospective, Randomized Pilot Trial of Model-Based Warfarin Dose Initiation using CYP2C9 Genotype and Clinical Data

2005 • 201 citations

Combined Aspirin–Oral Anticoagulant Therapy Compared With Oral Anticoagulant Therapy Alone Among Patients at Risk for Cardiovascular Disease

2007 • 201 citations

Quality Assessment of Anticoagulation Dose Management: Comparative Evaluation of Measures of Time-in-Therapeutic Range

2003 • 200 citations

Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial.

2003 • 199 citations

The Hemostatic Defect Produced by Carbenicillin

1974 • 196 citations

Role of Vitamin-K-Dependent Proteins in Bone Metabolism

1988 • 195 citations

A Randomized Trial Comparing 5-mg and 10-mg Warfarin Loading Doses

1999 • 194 citations

The international normalized ratio calibrated for cirrhosis (INRliver) normalizes prothrombin time results for model for end-stage liver disease calculation

2007 • 193 citations

Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration

1983 • 191 citations

Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin

2006 • 191 citations

Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype

2005 • 191 citations

Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: An exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials

2006 • 190 citations

Studies on Coumarin Anticoagulant Drugs

1968 • 190 citations

Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Rivaroxaban—an Oral, Direct Factor Xa Inhibitor—Are Not Affected by Aspirin

2006 • 183 citations

Factors affecting the maintenance dose of warfarin.

1992 • 182 citations

Low-Intensity Warfarin Is Ineffective for the Prevention of PTFE Graft Failure in Patients on Hemodialysis

2002 • 181 citations

Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor, Are Not Affected by Moderate Hepatic Impairment

2008 • 177 citations

Guidelines for the use of fresh frozen plasma

1992 • 173 citations

Evidence that warfarin anticoagulant action involves two distinct reductase activities.

1982 • 168 citations

Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients

1991 • 168 citations

Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban – an oral, direct Factor Xa inhibitor – in healthy subjects

2007 • 167 citations

Descriptive analysis of the process and quality of oral anticoagulation management in real-life practice in patients with chronic non-valvular atrial fibrillation: the international study of anticoagulation management (ISAM)

2007 • 165 citations

Oral Vitamin K Lowers the International Normalized Ratio More Rapidly Than Subcutaneous Vitamin K in the Treatment of Warfarin-Associated Coagulopathy

2002 • 163 citations

Duration of warfarin anticoagulant therapy and the probabilities of recurrent thromboembolism and hemorrhage

1986 • 161 citations

Risk of Upper Gastrointestinal Hemorrhage in Warfarin Users Treated With Nonselective NSAIDs or COX-2 Inhibitors

2005 • 160 citations

Rivaroxaban (BAY 59‐7939) – an oral, direct Factor Xa inhibitor – has no clinically relevant interaction with naproxen

2006 • 160 citations

Preadmission antithrombotic treatment and stroke severity in patients with atrial fibrillation and acute ischaemic stroke: an observational study

2006 • 160 citations

Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin

2006 • 159 citations

Thrombotic and Hemorrhagic Complications in Patients with Mechanical Heart Valve Prosthesis Attending an Anticoagulation Clinic

1993 • 159 citations

INTRAVENOUS FAT

1976 • 155 citations

Evolving models of warfarin management: Anticoagulation clinics, patient self-monitoring, and patient self-management

1996 • 155 citations

Thromboembolic and Bleeding Complications Following St. Jude Medical Valve Replacement

2005 • 154 citations

Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects

2004 • 152 citations

Coagulation Abnormalities in Liver Disease

1992 • 152 citations

Combining Antiplatelet and Anticoagulant Therapies

2009 • 152 citations

Human Sources and Absorption of Vitamin K in Relation to Anticoagulation Stability

1965 • 151 citations

The warfarin-sulfinpyrazone interaction: stereochemical considerations

1986 • 150 citations

Influence of CYP2C9 and VKORC1 on Warfarin Dose, Anticoagulation Attainment and Maintenance Among European–Americans and African–Americans

2008 • 149 citations

Vitamin K deficiency from dietary vitamin K restriction in humans

1988 • 147 citations

Drug-Induced Liver Injury in Humans: The Case of Ximelagatran

2009 • 146 citations

Treatment of coumarin‐associated coagulopathy: a systematic review and proposed treatment algorithms

2006 • 145 citations

Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial

2002 • 145 citations

Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. The Medical Research Council's General Practice Research Framework.

1998 • 145 citations

Warfarin

1984 • 144 citations

Effects of the Oral, Direct Factor Xa Inhibitor Rivaroxaban on Platelet‐Induced Thrombin Generation and Prothrombinase Activity¹

2007 • 143 citations

Warfarin and its interactions with foods, herbs and other dietary supplements

2006 • 139 citations

Biochemical basis of hereditary resistance to warfarin in the rat

1974 • 138 citations

Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon

2008 • 137 citations

Mechanism of the anticoagulant effect of warfarin as evaluated in rabbits by selective depression of individual procoagulant vitamin K-dependent clotting factors.

1993 • 136 citations

Effect of 3.2%vs3.8% Sodium Citrate Concentration on Routine Coagulation Testing

1997 • 136 citations

Guidelines for implementation of patient self-testing and patient self-management of oral anticoagulation. International consensus guidelines prepared by International Self-Monitoring Association for Oral Anticoagulation

2004 • 134 citations

Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation

2008 • 133 citations

Time Course of Reversal of Anticoagulant Effect of Warfarin by Intravenous and Subcutaneous Phytonadione

1999 • 132 citations

Clinical Pharmacokinetics of Oral Anticoagulants

1979 • 131 citations

The kinetics of activation of normal and gamma-carboxyglutamic acid-deficient prothrombins.

1985 • 131 citations

Risk factors for nonadherence to warfarin: results from the IN‐RANGE study

2008 • 130 citations

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 • 130 citations

Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts.

1992 • 130 citations

A modified international normalized ratio as an effective way of prothrombin time standardization in hepatology†

2007 • 130 citations

Mechanisms of thrombopoiesis

2005 • 129 citations

Oral Anticoagulation and Hemorrhagic Complications in an Elderly Population With Atrial Fibrillation

2001 • 128 citations

Outcomes and predictors of very stable INR control during chronic anticoagulation therapy

2009 • 127 citations

Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. An overview

2007 • 126 citations

The influence of sequence variations in factor VII, γ-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement

2006 • 125 citations

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1

2004 • 125 citations

Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid-binding site on prothrombin.

1986 • 124 citations

The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review

2002 • 123 citations

Prevention of thromboembolism in atrial fibrillation

2000 • 123 citations

Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation

2005 • 123 citations

Prospective comparative study of computer programs used for management of warfarin.

1993 • 122 citations

An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage

2008 • 121 citations

Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy).

1997 • 115 citations

Impact of Anticoagulation on Rebleeding Following Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Hemorrhage

2006 • 115 citations

Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans

1987 • 114 citations

A Review of Enzyme Induction of Warfarin Metabolism with Recommendations for Patient Management

1997 • 113 citations

Effectiveness of fixed minidose warfarin in the prevention of thromboembolism and vascular death in nonrheumatic atrial fibrillation∗∗The investigators and institutions participating in the study are listed in the Appendix.

1998 • 112 citations

Stereoselective Interaction of Trimethoprim-Sulfamethoxazole with the Separated Enantiomorphs of Racemic Warfarin in Man

1980 • 112 citations

Reduced Bone Density in Children on Long-Term Warfarin

2005 • 112 citations

Successful Progressive Anticoagulation in a Severe Protein C Deficiency and Previous Skin Necrosis at the Initiation of Oral Anticoagulant Treatment

1984 • 109 citations

The relationship between inhibition of vitamin K1 2,3‐epoxide reductase and reduction of clotting factor activity with warfarin.

1988 • 108 citations

In Vitro Metabolism of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans

2009 • 106 citations

Major haemorrhagic complications during oral anticoagulant therapy in a Danish Population‐based cohort

1997 • 106 citations

Warfarin dosing and cytochrome P450 2C9 polymorphisms

2004 • 106 citations

Stroke Prevention Using the Oral Direct Thrombin Inhibitor Ximelagatran in Patients with Non-Valvular Atrial Fibrillation

2006 • 105 citations

Effect of computer-aided management on the quality of treatment in anticoagulated patients: a prospective, randomized, multicenter trial of APROAT (Automated PRogram for Oral Anticoagulant Treatment).

2001 • 105 citations

A spectrum of partially carboxylated prothrombins in the plasmas of coumarin-treated patients

1977 • 104 citations

Are Capillary Whole Blood Coagulation Monitors Suitable for the Control of Oral Anticoagulant Treatment by the International Normalized Ratio?

1993 • 104 citations

Population Pharmacokinetic Analysis of the New Oral Thrombin Inhibitor Dabigatran Etexilate (BIBR 1048) in Patients Undergoing Primary Elective Total Hip Replacement Surgery

2007 • 103 citations

haplotype structure in European American warfarin patients and association with clinical outcomes

2005 • 103 citations

Poor anticoagulation quality in the first 3 months after unprovoked venous thromboembolism is a risk factor for long‐term recurrence

2005 • 103 citations

Vitamin K and the Oral Anticoagulant Drugs

1976 • 102 citations

Initiation of warfarin therapy in elderly medical inpatients: A safe and accurate regimen

2005 • 101 citations

Local Haemorrhage and Necrosis of the Skin and Underlying Tissues, During Anti‐Coagulant Therapy with Dicumarol or Dicumacyl

1954 • 101 citations

Risks factors for highly unstable response to oral anticoagulation: a case‐control study

2005 • 99 citations

Bleeding during acetylsalicylic acid and anticoagulant therapy in patients with reduced platelet reactivity after aortic valve replacement

1980 • 98 citations

Coadministration of Dabigatran Etexilate and Atorvastatin

2009 • 97 citations

New oral antithrombotics: a need for laboratory monitoring. For

2010 • 95 citations

Accuracy of Laboratory and Portable Monitor International Normalized Ratio Determinations

1995 • 95 citations

Safety assessment of new antithrombotic agents: Lessons from the EXTEND study on ximelagatran

2008 • 94 citations

The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon

2004 • 93 citations

A Comparison of Point-of-Care Instruments Designed for Monitoring Oral Anticoagulation with Standard Laboratory Methods

2000 • 92 citations

Venous Limb Gangrene during Warfarin Treatment of Cancer-Associated Deep Venous Thrombosis

2001 • 92 citations

A Novel Whole Blood Capillary Technic for Measuring the Prothrombin Time

1987 • 92 citations

Accuracy of a Portable International Normalization Ratio Monitor in Outpatients Receiving Long-Term Oral Anticoagulant Therapy

1998 • 92 citations

Computer control of anticoagulant dose for therapeutic management.

1989 • 90 citations

The Risk of Hemorrhage Among Patients With Warfarin-Associated Coagulopathy

2006 • 89 citations

Necrosis of skin induced by coumarin in a patient deficient in protein S.

1989 • 89 citations

An evidence‐based review and guidelines for patient self‐testing and management of oral anticoagulation

2005 • 88 citations

Paracetamol (acetaminophen) warfarin interaction: NAPQI, the toxic metabolite of paracetamol, is an inhibitor of enzymes in the vitamin K cycle

2004 • 87 citations

Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation11The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Defense or other Departments of the US Government.

1999 • 86 citations

Predictors of Noncompliance with Warfarin Therapy in an Outpatient Anticoagulation Clinic

2005 • 85 citations

Thrombotic Events during Oral Anticoagulant Treatment: Results of the Inception-cohort, Prospective, Collaborative ISCOAT Study

1997 • 85 citations

Oral anticoagulant drugs: pharmacokinetic aspects.

1978 • 85 citations

Accuracy and Precision of a Portable Anticoagulation Monitor in a Clinical Setting

1992 • 85 citations

Management patterns and outcomes of patients with venous thromboembolism in the usual community practice setting

2004 • 85 citations

Successful Warfarin Anticoagulation Despite Protein C Deficiency and a History of Warfarin Necrosis

1986 • 84 citations

Ecarin Chromogenic Assay – A New Method for Quantitative Determination of Direct Thrombin Inhibitors Like Hirudin

2003 • 83 citations

Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man

1980 • 83 citations

Daily vitamin K supplementation improves anticoagulant stability

2007 • 82 citations

Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats

2007 • 82 citations

Patient education and oral anticoagulant therapy.

2002 • 82 citations

Randomized, Placebo‐Controlled Trial of Oral Phytonadione for Excessive Anticoagulation

2000 • 82 citations

Fibrate/Statin Initiation in Warfarin Users and Gastrointestinal Bleeding Risk

2010 • 80 citations

Therapeutic quality control of oral anticoagulant therapy comparing the short‐acting acenocoumarol and the long‐acting phenprocoumon

2002 • 79 citations

The Effect of Extreme Age, and Gender, on the Pharmacology and Tolerability of Rivaroxaban - An Oral, Direct Factor Xa Inhibitor.

2006 • 79 citations

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

1997 • 78 citations

College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: laboratory monitoring of oral anticoagulant therapy.

1998 • 78 citations

Results of the performance verification of the CoaguChek XS system

2008 • 76 citations

Does Statin Therapy Decrease the Risk for Bleeding in Patients Who Are Receiving Warfarin?

2007 • 75 citations

Pharmacokinetics of the enantiomers of acenocoumarol in man.

1981 • 73 citations

Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects

2009 • 73 citations

The optimal intensity of vitamin k antagonists in patients with mechanical heart valves

2003 • 72 citations

The Dependence of the International Sensitivity Index on the Coagulometer Used to Perform the Prothrombin Time

1990 • 71 citations

The risk of bleeding with warfarin: A systematic review and performance analysis of clinical prediction rules

2007 • 70 citations

Twelve‐month outcomes and predictors of very stable INR control in prevalent warfarin users

2010 • 70 citations

The Association of Age with Dosage Requirement for Warfarin

1991 • 70 citations

Frequency and effect of optimal anticoagulation before onset of ischaemic stroke in patients with known atrial fibrillation

2005 • 69 citations

The Effect of Some Instruments for Prothrombin Time Testing on the International Sensitivity Index (ISI) of Two Rabbit Tissue Thromboplastin Reagents

1989 • 69 citations

A comparative study on the quality of oral anticoagulant therapy (warfarin versus acenocoumarol).

1994 • 69 citations

Drug interactions update: drugs, herbs, and oral anticoagulation.

2001 • 68 citations

Effects of Penicillin G on Platelet Aggregation, Release, and Adherence to Collagen

1973 • 68 citations

Interaction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized study.

2006 • 67 citations

What Is the Evidence for the Off-label Use of Recombinant Factor VIIa (rFVIIa) in the Acute Reversal of Warfarin?

2008 • 67 citations

Prevention and treatment of bleeding complications in patients receiving vitamin K antagonists, Part 1: Prevention

2009 • 67 citations

Comparison of Two Automated Coagulometers and the Manual Tilt-Tube Method for the Determination of Prothrombin Time

1989 • 66 citations

Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban – an oral, direct factor Xa inhibitor – in elderly Chinese subjects

2009 • 66 citations

Anticoagulant Associated Hematuria: A Prospective Study

1995 • 65 citations

Systematic review of studies of self-management of oral anticoagulation

2004 • 65 citations

A Randomized Comparison of a Computer-Based Dosing Program with a Manual System to Monitor Oral Anticoagulant Therapy

1998 • 65 citations

Significance of occult gastrointestinal bleeding during anticoagulation therapy

1987 • 64 citations

Computer assisted management of warfarin treatment.

1984 • 64 citations

Potential Interactions between Exercise and Drug Therapy

2004 • 63 citations

Prediction of hemorrhage during long-term oral coumarin anticoagulation by excessive prothrombin ratio

1982 • 62 citations

Effect of automation on prothrombin time test in NEQAS surveys.

1989 • 62 citations

Over-the-counter vitamin K1-containing multivitamin supplements disrupt warfarin anticoagulation in vitamin K1-depleted patients

2004 • 61 citations

The Significance of Hematuria in the Anticoagulated Patient

1994 • 61 citations

Effect of Sodium Dextrothyroxine in Patients Receiving Anticoagulants

1962 • 61 citations

Effect of Concentration of Trisodium Citrate Anticoagulant on Calculation of the International Normalised Ratio and the International Sensitivity Index of Thromboplastin

1994 • 61 citations

LONG-TERM ORAL ANTICOAGULANT THERAPY IN ELDERLY PATIENTS

1988 • 60 citations

A Computer Generated Induction System for Hospitalized Patients Starting on Oral Anticoagulant Therapy

2000 • 60 citations

Prevention and treatment of bleeding complications in patients receiving vitamin K antagonists, part 2: Treatment

2009 • 60 citations

The challenges of new drugs benefits and risks analysis: Lessons from the ximelagatran FDA Cardiovascular Advisory Committee

2006 • 58 citations

Interaction of Dietary Factors with Oral Anticoagulants

1995 • 58 citations

Comparison of a daily fixed 2.5-mg warfarin dose with a 5-mg, international normalized ratio adjusted, warfarin dose initially following heart valve replacement

2001 • 56 citations

Bleeding during antithrombotic therapy in patients with atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators.

1996 • 56 citations

Evaluation of the Ciba Corning Biotrack 512 coagulation monitor for the control of oral anticoagulation.

1991 • 56 citations

Mini-series: I. Basic science. Uncertainty and inaccuracy of predicting CYP-mediated in vivo drug interactions in the ICU from in vitro models: focus on CYP3A4

2009 • 56 citations

Point-of-care testing for patients with diabetes, hyperlipidaemia or coagulation disorders in the general practice setting: a systematic review

2009 • 55 citations

Gastrointestinal bleeding in patients receiving long-term anticoagulant therapy

1988 • 55 citations

Influence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy

2009 • 55 citations

Correction of instrument- and reagent-based differences in determination of the International Normalized Ratio (INR) for monitoring anticoagulant therapy.

1989 • 54 citations

Reliability of international normalised ratios from two point of care test systems: comparison with conventional methods

2003 • 54 citations

Results of an open-label, prospective study of anticoagulant therapy for atrial fibrillation in an outpatient anticoagulation clinic

2004 • 54 citations

Validation of the international normalized ratio (INR) in a new point‐of‐care system designed for home monitoring of oral anticoagulation therapy

2007 • 53 citations

A Comparison of INRs Determined with a Whole Blood Prothrombin Time Device and two International Reference Preparations for Thromboplastin

2000 • 53 citations

Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy

2009 • 53 citations

INTERACTION OF IBUPROFEN AND WARFARIN ON PRIMARY HAEMOSTASIS

1989 • 53 citations

Dietary supplements, herbs and oral anticoagulants: the nature of the evidence

2007 • 53 citations

Low-Dose Vitamin K to Augment Anticoagulation Control

2005 • 53 citations

CYP2C9 and oral anticoagulation therapy with acenocoumarol and warfarin: similarities yet differences

2004 • 53 citations

Accuracy of a Portable Prothrombin Time Monitor (Coagucheck) in Patients on Chronic Oral Anticoagulant Therapy

2000 • 52 citations

Warfarin Necrosis of the Skin and Subcutaneous Tissue of the Male External Genitalia

1983 • 52 citations

Failure of the International Normalized Ratio to Generate Consistent Results Within a Local Medical Community

1993 • 52 citations

Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis

2007 • 52 citations

Effect of erythromycin in patients receiving long-term warfarin therapy.

1989 • 52 citations

Age-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8

1990 • 51 citations

New Anticoagulant Agents: Direct Thrombin Inhibitors

2008 • 51 citations

Sequence of the precursor to rat bone gamma-carboxyglutamic acid protein that accumulates in warfarin-treated osteosarcoma cells.

1985 • 50 citations

Clinical Significance of Hematuria in Patients on Anticoagulant Therapy

1987 • 49 citations

Hematologic perturbations associated with salicylate

1979 • 49 citations

The reliability of point‐of‐care prothrombin time testing. A comparison of CoaguChek S^® and XS^® INR measurements with hospital laboratory monitoring

2008 • 49 citations

Thromboembolic Consequences of Subtherapeutic Anticoagulation in Patients Stabilized on Warfarin Therapy: The Low INR Study

2008 • 48 citations

International Normalized Ratio Self-Management Lowers the Risk of Thromboembolic Events After Prosthetic Heart Valve Replacement

2008 • 48 citations

Herbal remedies and anticoagulant therapy

2004 • 47 citations

Anticoagulation clinics and the monitoring of anticoagulant therapy

1988 • 47 citations

Warfarin Interactions With Substances Listed in Drug Information Compendia and in the FDA-Approved Label for Warfarin Sodium

2009 • 47 citations

Controlled Vitamin K Content Diet for Improving the Management of Poorly Controlled Anticoagulated Patients: A Clinical Practice Proposal

1993 • 47 citations

Low Dose Oral Vitamin K to Reverse Acenocoumarol-induced Coagulopathy: A Randomized Controlled Trial

2002 • 47 citations

Automation and prothrombin time: a United Kingdom field study of two widely used coagulometers.

1990 • 46 citations

Point-of-care testing of the international normalized ratio in patients with antiphospholipid antibodies

2005 • 45 citations

Decentralized testing for prothrombin time and activated partial thromboplastin time using a dry chemistry portable analyzer.

1993 • 45 citations

Prospective study of supplemental vitamin K therapy in patients on oral anticoagulants with unstable international normalized ratios

2007 • 45 citations

Reliability of the international normalized ratio for monitoring the induction phase of warfarin: Comparison with the prothrombin time ratio

1996 • 44 citations

Lack of Effect of Fortified Wine Ingested During Fasting and Anticoagulant Therapy

1981 • 42 citations

Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients*

1998 • 41 citations

Determination of the International Sensitivity Index of a new near-patient testing device to monitor oral anticoagulant therapy--overview of the assessment of conformity to the calibration model.

1997 • 41 citations

Studies on the Interaction of Warfarin and Clofibrate in Man

1972 • 40 citations

Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy

2010 • 40 citations

Transfusion-Related Acute Lung Injury: Incidence, Pathogenesis and the Role of Multicomponent Apheresis in Its Prevention

2008 • 39 citations

Low-Intensity Anticoagulation in Mechanical Cardiac Prosthetic Valves

1991 • 38 citations

Comparison of INR stability between self-monitoring and standard laboratory method: Preliminary results of a prospective study in 67 mechanical heart valve patients

2008 • 37 citations

Influence of Fever Upon the Action of 3,3′-Methylene-Bis-(4-Hydroxycoumarin) (Dicumarol)

1943 • 36 citations

Self-Management of Oral Anticoagulant Therapy: A Review

2004 • 36 citations

Does heart failure exacerbation increase response to warfarin?A critical review of the literature

2006 • 36 citations

Point-of-Care Prothrombin Time Measurement for Professional and Patient Self-Testing Use

2001 • 35 citations

Bedside monitoring of warfarin therapy by a whole blood capillary coagulation monitor

1992 • 33 citations

Reversal of excessive oral anticoagulation with a low oral dose of vitamin K1 compared with acenocoumarine discontinuation. A prospective, randomized, open study

2001 • 33 citations

Evaluation of a capillary whole-blood prothrombin time measurement system.

1989 • 33 citations

European Concerted Action on Anticoagulation (ECAA): multicentre international sensitivity index calibration of two types of point‐of‐care prothrombin time monitor systems

2002 • 33 citations

Long-term anticoagulation therapy for atrial fibrillation in elderly patients: efficacy, risk, and current patterns of use.

1999 • 32 citations

The cost‐effectiveness of computer‐assisted anticoagulant dosage: results from the European Action on Anticoagulation (EAA) multicentre study

2009 • 32 citations

The interval between prothrombin time tests and the quality of oral anticoagulants treatment in patients with chronic atrial fibrillation

2006 • 32 citations

Point-of-care International Normalised Ratios: UK NEQAS experience demonstrates necessity for proficiency testing of three different monitors

2006 • 31 citations

Influence of Physical Activity on Warfarin Therapy

1998 • 31 citations

Managing oral anticoagulation therapy: Clinical and operational guidelines

2002 • 31 citations

Evaluation of Warfarin Initiation Regimens in Elderly Inpatients

2000 • 31 citations

Decreased Thrombin Activity of Fibrin Clots Prepared in Cord Plasma Compared with Adult Plasma

1996 • 31 citations

Ximelagatran and melagatran vs. low‐molecular‐weight heparin in major orthopedic surgery: relationship between efficacy and safety and timing of initial administration

2005 • 30 citations

A Comparison Between Six- and Four-Week Intervals in Surveillance of Oral Anticoagulant Treatment

2003 • 29 citations

Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: Evidence for multiple pathways of hydroxyvitamin K formation

1988 • 27 citations

Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction. Coumadin Aspirin Reinfarction Study (CARS) Investigators.

1997 • 27 citations

External quality assessment (EQA) for CoaguChek monitors

2010 • 25 citations

Determination of the International Sensitivity Index of a New Near-Patient Testing Device to Monitor Oral Anticoagulant Therapy

1997 • 25 citations

CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese

2006 • 25 citations

Azathioprine and inhibition of the anticoagulant effect of warfarin: Evidence from a case report and a literature review

2006 • 25 citations

Monitoring oral anticoagulant treatment with the TAS near-patient test system: comparison with conventional thromboplastins.

1997 • 25 citations

Evaluation of International Normalized Ratios by a Controlled Field Survey with 4 Different Thromboplastin Reagents

1990 • 24 citations

Incidence of thromboembolic complications in patients with mechanical heart valves with a subtherapeutic international normalized ratio

2008 • 24 citations

Status of Present and Candidate International Reference Preparations (IRP) of Thromboplastin for the Prothrombin Time

1993 • 24 citations

Accuracy and precision of the TAS analyser for near-patient INR testing by non-pathology staff in the community.

1998 • 23 citations

Enantiomers of Warfarin and Phenobarbital

1976 • 23 citations

Falsely Elevated International Normalized Ratio Values in Patients Undergoing Anticoagulation Therapy

2007 • 22 citations

Purple Toes Syndrome Associated with Warfarin Therapy in a Patient with Antiphospholipid Syndrome

2003 • 22 citations

Thromboplastin Composition Affects the Sensitivity of Prothrombin Time (PT) Clotting Tests To Direct Factor Xa Inhibitors.

2007 • 22 citations

RIVAROXABAN - AN ORAL, DIRECT FACTOR XA INHIBITOR - BINDS RAPIDLY TO FACTOR XA

2007 • 18 citations

Increase in International Normalized Ratio After Smoking Cessation in a Patient Receiving Warfarin

2005 • 18 citations

European Concerted Action on Anticoagulation (ECAA). An assessment of lyophilised plasmas for ISI calibration of CoaguChek and TAS whole blood prothrombin time monitors

2003 • 18 citations

Clinical impact of interlaboratory variation in International Normalized Ratio determinations

2001 • 16 citations

Potentiation of warfarin anticoagulation by topical testosterone ointment.

1985 • 16 citations

Computer control of anticoagulant dose

1989 • 16 citations

WHO Expert Committee on Biological Standardization. Thirty-third report.

1983 • 16 citations

Thromboplastin standards

2010 • 15 citations

Purple toe syndrome following anticoagulant therapy

2001 • 14 citations

A novel sequence variant in exon 7 of CYP2C9 gene (CYP2C9*24) ina patient on warfarin therapy

2006 • 14 citations

Possible Warfarin Failure Due to Interaction with Smokeless Tobacco

2004 • 13 citations

Lessons From Ximelagatran: Issues for Future Studies Evaluating New Oral Direct Thrombin Inhibitors for Venous Thromboembolism Prophylaxis in Orthopedic Surgery

2008 • 12 citations

Clinically significant differences in the International Normalized Ratio measured with reagents of different sensitivities

1999 • 12 citations

The Importance of Factor Xa Regulatory Pathways in Vascular Thromboresistance: Focus on Protein Z

2005 • 10 citations

Assessing agreement between point of care and pathology laboratory results for INR: experiences from the Point of Care Testing in General Practice Trial

2010 • 8 citations

A Comparison Between Six- and Four-Week Intervals in Surveillance of Oral Anticoagulant Treatment

2003 • 7 citations

Prothrombin measurement using a patient self-testing system. Oral Anticoagulation Monitoring Study Group.

2001 • 7 citations

Deleted Work

1955 • 0 citations