The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

Oral anticoagulants: mechanism of action, clinical effectiveness, and optimal therapeutic range.

2001 • 1,801 citations

Heparin

1991 • 809 citations

A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial

2004 • 424 citations

Pharmacokinetic Profile of the Oral Direct Thrombin Inhibitor Dabigatran Etexilate in Healthy Volunteers and Patients Undergoing Total Hip Replacement

2005 • 291 citations

Ximelagatran versus Warfarin for the Prevention of Venous Thromboembolism after Total Knee Arthroplasty

2002 • 212 citations

The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review

2003 • 152 citations

Combined administration of aspirin and a specific thrombin inhibitor in man.

1991 • 102 citations

Management of Venous Thromboembolism

2003 • 83 citations

Monitoring of Anticoagulant Effects of Direct Thrombin Inhibitors

2002 • 61 citations

Clinical Monitoring of Hirudin and Direct Thrombin Inhibitors

2001 • 56 citations

TopFit: a PC-based pharmacokinetic/pharmacodynamic data analysis program.

1993 • 55 citations

Comparing Direct Thrombin Inhibitors Using aPTT, Ecarin Clotting Times, and Thrombin Inhibitor Management Testing

2004 • 54 citations

Ximelagatran versus Warfarin for the Prevention of Venous Thromboembolism after Total Knee Arthroplasty

2002 • 53 citations

A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays

2004 • 32 citations

Laboratory Assessment of Antithrombotic Therapy: What Tests and If So Why?

1997 • 20 citations

Population modelling of the effect of inogatran, at thrombin inhibitor, on ex vivo coagulation time (APTT) in healthy subjects and patients with coronary artery disease

2001 • 20 citations

Oral Direct Thrombin Inhibition

2004 • 14 citations

Clinical pharmacology and drug safety: Lessons from hirudin*

1995 • 11 citations

Clinical Potential of Oral Direct Thrombin Inhibitors in the Prevention and Treatment of Venous Thromboembolism

2004 • 7 citations

Visuvalve Software: An Aid to the Diagnosis of Shunt Failure

1997 • 7 citations

New Blood Thinner Offers First Potential Alternative in 50 Years

2004 • 5 citations

Orally Active Direct Thrombin Inhibitors

2003 • 3 citations

Deleted Work

1955 • 0 citations