Mechanisms of thrombopoiesis

Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools

1998 • 820 citations

Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions

2003 • 774 citations

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

2003 • 755 citations

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

2002 • 751 citations

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

1997 • 723 citations

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

1995 • 712 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

1997 • 683 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

2004 • 584 citations

Bernard-Soulier Syndrome

1998 • 552 citations

Blood Platelets Are Assembled Principally at the Ends of Proplatelet Processes Produced by Differentiated Megakaryocytes

1999 • 538 citations

Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts

2002 • 526 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 515 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes

2000 • 420 citations

Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing

2000 • 400 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

2003 • 378 citations

Transcript profiling of human platelets using microarray and serial analysis of gene expression

2003 • 375 citations

Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional

1995 • 369 citations

Fli-1 Is Required for Murine Vascular and Megakaryocytic Development and Is Hemizygously Deleted in Patients with Thrombocytopenia

2000 • 366 citations

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1999 • 354 citations

Platelet formation is the consequence of caspase activation within megakaryocytes

2002 • 335 citations

Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets

1999 • 327 citations

Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors

1995 • 285 citations

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

2004 • 278 citations

Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL

1997 • 266 citations

Generation and rescue of a murine model of platelet dysfunction: The Bernard-Soulier syndrome

2000 • 262 citations

Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly

2000 • 249 citations

A lineage-restricted and divergent β-tubulin isoform is essential for the biogenesis, structure and function of blood platelets

2001 • 246 citations

Natural history of GATA1 mutations in Down syndrome

2003 • 244 citations

Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice

2002 • 232 citations

Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice)

2002 • 224 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

Origins of leukaemia in children with Down syndrome

2005 • 210 citations

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S ₁₂

2003 • 209 citations

A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation

1996 • 206 citations

The mechanism of spindle assembly

2004 • 206 citations

Murine Hermansky–Pudlak syndrome genes: regulators of lysosome‐related organelles

2004 • 196 citations

When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin

1998 • 188 citations

A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration

2001 • 185 citations

Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins

2003 • 173 citations

The demarcation membrane system of the megakaryocyte: a misnomer?

1982 • 173 citations

The mechanism of platelet release

1980 • 171 citations

Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to Megakaryocytes

1998 • 171 citations

Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome

2003 • 170 citations

Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2

2000 • 170 citations

Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation

1992 • 167 citations

GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

2002 • 166 citations

Identification of the phosphotyrosine proteome from thrombin activated platelets

2002 • 161 citations

Mechanisms and implications of platelet discoid shape

2003 • 155 citations

Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis

2000 • 151 citations

Thrombopoietin-induced Polyploidization of Bone Marrow Megakaryocytes Is Due to a Unique Regulatory Mechanism in Late Mitosis

1997 • 143 citations

Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets

1999 • 142 citations

Megakaryocyte-Osteoblast Interaction Revealed in Mice Deficient in Transcription Factors GATA-1 and NF-E2

2004 • 134 citations

The birth of the platelet

2003 • 134 citations

Parasinusoidal location of megakaryocytes in marrow: A determinant of platelet release

1978 • 114 citations

Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice

2004 • 112 citations

Cell-Intrinsic Timers and Thyroid Hormone Regulate the Probability of Cell-Cycle Withdrawal and Differentiation of Oligodendrocyte Precursor Cells

1998 • 107 citations

Differential regulation of actin stress fiber assembly and proplatelet formation by α2β1 integrin and GPVI in human megakaryocytes

2004 • 101 citations

Atlas of Blood Cells. Function and Pathology.

1981 • 100 citations

Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol

2003 • 99 citations

Human marrow megakaryocyte differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes

2004 • 98 citations

Thrombocytopoiesis--analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes.

1984 • 97 citations

A role for Rab27b in NF-E2-dependent pathways of platelet formation

2003 • 97 citations

Genetic deletion of mouse platelet glycoprotein Ibβ produces a Bernard-Soulier phenotype with increased α-granule size

2004 • 88 citations

Perinatal synthetic lethality and hematopoietic defects in compound mafG::mafK mutant mice

2000 • 84 citations

Characterization of adhesive interactions between human endothelial cells and megakaryocytes.

1993 • 84 citations

p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes

1997 • 79 citations

Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage

2004 • 66 citations

Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen

2004 • 56 citations

Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibα

2004 • 50 citations

Caspase-12: a developmental link between G-protein–coupled receptors and integrin αIIbβ3 activation

2004 • 41 citations

Gene Expression Profile of Megakaryocytes from Human Cord Blood CD34+ Cells Ex Vivo Expanded by Thrombopoietin

2002 • 41 citations

Megakaryocyte–Bone Marrow Stromal Cell Aggregates Demonstrate Increased Colony Formation and Alkaline Phosphatase Expressionin Vitro

2004 • 40 citations

Zinc Finger Protein, Hzf, Is Required for Megakaryocyte Development and Hemostasis

2002 • 39 citations

Expression of osteoprotegerin mRNA and protein in murine megakaryocytes

2003 • 37 citations

Molecular Mechanisms of Megakaryocyte Differentiation

2004 • 35 citations

Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors α and β

2004 • 32 citations

Cell-to-cell variability in the differentiation program of human megakaryocytes

2003 • 29 citations

Interactions between the megakaryocyte/platelet-specific β1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions

2004 • 28 citations

Atlas of Blood Cells: Function and Pathology

1989 • 25 citations

Bernard–Soulier syndrome with a homozygous 13 base pair deletion in the signal peptide-coding region of the platelet glycoprotein Ibβ gene

2003 • 21 citations

Antigenic differences between human platelets and megakaryocytes.

1987 • 18 citations

Thrombopoietin responsiveness reflects the number of doublings undergone by megakaryocyte progenitors

2004 • 10 citations

The relative population sizes of megakaryocytic cells in mouse bone marrow as determined by mpl ligand responsiveness.

1997 • 7 citations

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