Extracellular Calcium Controls the Dynamic Range of Neuronal Metabotropic Glutamate Receptor Responses

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

1993 • 2,625 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Ionic Channels of Excitable Membranes, 2nd Ed.

1992 • 1,283 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

2000 • 1,197 citations

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction

1993 • 905 citations

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

1994 • 884 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

1994 • 730 citations

Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity

1994 • 713 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Principles of Drug Action: The Basis of Pharmacology.

1975 • 616 citations

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice

1994 • 607 citations

Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors

2001 • 558 citations

Calcium control of transmitter release at a cerebellar synapse

1995 • 532 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites

1998 • 521 citations

Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer

1996 • 512 citations

Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

1999 • 451 citations

Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization

1994 • 420 citations

A new class of synaptic response involving calcium release in dendritic spines

1998 • 415 citations

mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination

2000 • 412 citations

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

1991 • 405 citations

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

2001 • 397 citations

Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites

1997 • 391 citations

Persistent Multiple Climbing Fiber Innervationof Cerebellar Purkinje Cellsin Mice Lacking mGluR1

1997 • 300 citations

A Promoter That Drives Transgene Expression in Cerebellar Purkinje and Retinal Bipolar Neurons

1990 • 282 citations

Calcium-induced calcium release in cerebellar purkinje cells

1994 • 279 citations

Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells

1994 • 274 citations

Quisqualate receptors are specifically involved in cerebellar synaptic plasticity

1987 • 273 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

Structural Basis for a Ca ²⁺ -Sensing Function of the Metabotropic Glutamate Receptors

1998 • 216 citations

Neuronal Glutamate Transporters Control Activation of Postsynaptic Metabotropic Glutamate Receptors and Influence Cerebellar Long-Term Depression

2001 • 202 citations

Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway

1997 • 197 citations

Roles of metabotropic glutamate receptors in LTP and LTD in

1999 • 196 citations

3,5-Dihydroxyphenylglycine

1992 • 195 citations

High endogenous calcium buffering in Purkinje cells from rat cerebellar slices.

1996 • 184 citations

Calcium transients in cerebellar granule cell presynaptic terminals

1995 • 166 citations

Intradendritic release of calcium induced by glutamate in cerebellar purkinje cells

1991 • 158 citations

Principles of Drug Action. The Basis of Pharmacology

1991 • 158 citations

Postsynaptic Current Mediated by Metabotropic Glutamate Receptors in Cerebellar Purkinje Cells

1998 • 150 citations

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

1996 • 139 citations

Pharmacological and immunocytochemical characterization of metabotropic glutamate receptors in cultured Purkinje cells

1992 • 116 citations

Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

1991 • 103 citations

Characterization of the mGluR₁-Mediated Electrical and Calcium Signaling in Purkinje Cells of Mouse Cerebellar Slices

2001 • 83 citations

Assessment of frequency-dependent alterations in the level of extracellular Ca2+ in the synaptic cleft

1997 • 82 citations

A reliable method for culture of dissociated mouse cerebellar cells enriched for Purkinje neurons

2000 • 79 citations

The conductance underlying the parallel fibre slow EPSP in rat cerebellar Purkinje neurones studied with photolytic release of L‐glutamate

2001 • 75 citations

Immunolocalization of the mGluR1b Splice Variant of the Metabotropic Glutamate Receptor 1 at Parallel Fiber‐Purkinje Cell Synapses in the Rat Cerebellar Cortex

2000 • 73 citations

Group I Metabotropic Glutamate Receptors Mediate an Inward Current in Rat Substantia Nigra Dopamine Neurons That Is Independent From Calcium Mobilization

1999 • 70 citations

The C‐Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists

1996 • 67 citations

Phospholipase C-Independent Group I Metabotropic Glutamate Receptor-Mediated Inward Current in Mouse Purkinje Cells

1998 • 57 citations

Reassessment of the Ca2+ Sensing Property of a Type I Metabotropic Glutamate Receptor by Simultaneous Measurement of Inositol 1,4,5-Trisphosphate and Ca2+ in Single Cells

2001 • 50 citations

A modulatory effect of extracellular Ca2+ on type 1α metabotropic glutamate receptor-mediated signalling

1998 • 50 citations

Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate

1996 • 26 citations

Extracellular Ca2+ sensitivity of mGluR1alpha associated with persistent glutamate response in transfected CHO cells.

2000 • 21 citations

A subpopulation of cerebellar granule neurons in culture expresses a functional mGluR1 metabotropic glutamate receptor: effect of depolarizing growing conditions.

1993 • 15 citations

Modulation of metabotropic glutamate receptor responses by extracellular calcium in cerebellar Purkinje cells

2000 • 2 citations