The Cyclin-dependent Kinase Inhibitor p21WAF1/Cip1 Is an Antiestrogen-regulated Inhibitor of Cdk4 in Human Breast Cancer Cells

Cancer Cell Cycles

1996 • 5,379 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

The Pezcoller lecture: cancer cell cycles revisited.

2000 • 1,208 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Inhibition of cyclin-dependent kinases by p21.

1995 • 999 citations

Cyclins and cancer

1991 • 701 citations

Estrogen-induced Activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased Cyclin D1 Expression and Decreased Cyclin-dependent Kinase Inhibitor Association with Cyclin E-Cdk2

1997 • 438 citations

Cell-cycle inhibitors: three families united by a common cause

2000 • 428 citations

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.

1996 • 344 citations

Convergence of Mitogenic Signalling Cascades from Diverse Classes of Receptors at the Cyclin D–Cyclin-Dependent Kinase–pRb-Controlled G₁ Checkpoint

1996 • 331 citations

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

1994 • 299 citations

Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution

1997 • 277 citations

Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase.

1983 • 275 citations

c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry

1998 • 257 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells.

1996 • 233 citations

Down-regulation of p21 ^WAF1/CIP1 or p27 ^Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

2000 • 227 citations

Control of the G1/S transition.

1997 • 219 citations

Mammalian G1 cyclins

1994 • 219 citations

Tamoxifen induces accumulation of MCF 7 human mammary carcinoma cells in the G0/G1 phase of the cell cycle

1983 • 208 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 Function

2001 • 185 citations

Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins.

1995 • 185 citations

Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors

1999 • 179 citations

A Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase

1997 • 179 citations

Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation.

1995 • 179 citations

Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage

1996 • 173 citations

Dephosphorylation of Cdk2 Thr ¹⁶⁰ by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

1995 • 170 citations

The role of RB in cell cycle control

1995 • 156 citations

Reasoning With Statistics: How To Read Quantitative Research

1986 • 153 citations

A Pure Estrogen Antagonist Inhibits Cyclin E-Cdk2 Activity in MCF-7 Breast Cancer Cells and Induces Accumulation of p130-E2F4 Complexes Characteristic of Quiescence

2000 • 148 citations

Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells

1994 • 124 citations

Inducible overexpression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogens.

1997 • 113 citations

The Stockholm trial on adjuvant tamoxifen in early breast cancer

1987 • 109 citations

Complete inhibition of Cdk/cyclin by one molecule of p21^Cip1

1998 • 108 citations

Distinct Roles for PP1 and PP2A in Phosphorylation of the Retinoblastoma Protein

1999 • 106 citations

Human breast cancer cell cycle synchronization by estrogens and antiestrogens in culture.

1984 • 105 citations

The Protein SET Regulates the Inhibitory Effect of p21Cip1 on Cyclin E-Cyclin-dependent Kinase 2 Activity

1999 • 88 citations

D-Type Cyclins and Their Cyclin-dependent Kinases: G1 Phase Integrators of the Mitogenic Response

1994 • 74 citations

p27KIP1, an inhibitor of cyclin-dependent kinases

1995 • 52 citations

Constitutive overexpression of cyclin D1 does not prevent inhibition of hormone-responsive human breast cancer cell growth by antiestrogens.

1998 • 34 citations

The Biphasic Induction of p21 and p27 in Breast Cancer Cells by Modulators of cAMP Is Posttranscriptionally Regulated and Independent of the PKA Pathway

1999 • 19 citations

Stoichiometry of Cyclin A−Cyclin-Dependent Kinase 2 Inhibition by p21^Cip1/Waf1

2000 • 18 citations

The Cell Cycle Inhibitor p21CIPIs Phosphorylated by Cyclin A-CDK2 Complexes

1997 • 15 citations