The Biphasic Induction of p21 and p27 in Breast Cancer Cells by Modulators of cAMP Is Posttranscriptionally Regulated and Independent of the PKA Pathway

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Cancer Cell Cycles

1996 • 5,379 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

1991 • 468 citations

Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?

1989 • 451 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Viewpoint: Putting the Cell Cycle in Order

1996 • 357 citations

Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275

1992 • 344 citations

Lovastatin-mediated G ₁ arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

1999 • 344 citations

Cdk inhibitors: on the threshold of checkpoints and development

1994 • 326 citations

Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm

1994 • 312 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

Melatonin Production: Proteasomal Proteolysis in Serotonin N -Acetyltransferase Regulation

1998 • 284 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells

1997 • 238 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

Deregulation of cyclin E in breast cancer.

1995 • 227 citations

Proteasome-Dependent Regulation of p21WAF1/CIP1Expression

1996 • 223 citations

Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells

1977 • 222 citations

Cell cycle regulation by the ubiquitin pathway

1997 • 214 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

1997 • 193 citations

Cyclic Nucleotide-gated Channels on the Flagellum Control Ca2+ Entry into Sperm

1998 • 186 citations

Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53

1998 • 180 citations

Inhibition of the 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Pathway Induces p53-independent Transcriptional Regulation of p21 in Human Prostate Carcinoma Cells

1998 • 161 citations

Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP

1993 • 157 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis

1996 • 109 citations

Proteasomes regulate the motility of salmonid fish sperm through modulation of cAMP-dependent phosphorylation of an outer arm dynein light chain

1998 • 106 citations

Forskolin: A potential antimetastatic agent

1983 • 104 citations

Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion.

1997 • 89 citations

Cyclin dependent kinase inhibitors.

1997 • 86 citations

3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition.

1993 • 84 citations

Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.

1992 • 70 citations

Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin–proteasome pathway

1997 • 54 citations

Transcriptional Inactivation of c-myc and the Transferrin Receptor in Dibutyryl Cyclic AMP-Treated HL-60 Cells

1987 • 54 citations

A Proteasome Activator Subunit Binds Calcium

1995 • 49 citations

Differential control of cyclins D1 and D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss 3T3 cells

1997 • 47 citations

The Oxytocin‐induced Inward Current in Vagal Neurons of the Rat is Mediated by G Protein Activation but not by an Increase in the lntracellular Calcium Concentration

1997 • 41 citations

Lovastatin inhibits mesangial cell proliferation via p27Kip1.

1998 • 41 citations

The Ubiquitin–Proteasome System and Cellular Proliferation and Regulation in Osteoblastic Cells

1998 • 40 citations

Role of Cyclic Adenosine 3′,5′- Monophosphate-Dependent Protein Kinase in Hormone-Stimulated β-Endorphin Secretion in AtT20 Cells

1991 • 35 citations

Rapid transcriptional down-regulation of c-myc expression during cyclic adenosine monophosphate-promoted differentiation of leukemic cells.

1987 • 35 citations

Results of intensive long-term treatment of familial hypercholesterolemia

1996 • 34 citations

Regulation of the Cell Cycle at the G2/M Boundary in Metastatic Melanoma Cells by 12-O-Tetradecanoyl Phorbol-13-acetate (TPA) by Blocking p34cdc2Kinase Activity

1998 • 33 citations

Regulation of Cl- transport in T84 cell clones expressing a mutant regulatory subunit of cAMP-dependent protein kinase.

1990 • 33 citations

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells.

1987 • 31 citations

Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer.

1990 • 30 citations

Cyclin-dependent kinase inhibitor P27kip1 is expressed at high levels in cells that express a myelinating phenotype

1997 • 26 citations

Proliferative responses of epithelial cells to 8‐bromo‐cyclic AMP and to a phorbol ester change during breast Pathogenesis

1994 • 26 citations

The actions of lovastatin on platelet function and platelet eicosanoid receptors in type II hypercholesterolaemia

1993 • 22 citations

Biological activity of p27kip1 and its amino- and carboxy-terminal domains in G2/M transition of Xenopus oocytes

1997 • 19 citations

Lovastatin inhibits cAMP- and calcium-stimulated chloride secretion by T84 cells

1993 • 13 citations

Lovastatin decreases prolactin and growth hormone gene expression in GH4C1 cells through a cAMP dependent mechanism

1997 • 12 citations

Synchronization of mammalian cells by Lovastatin

1996 • 6 citations

cAMP effect on extracellular matrix synthesis in human breast cancer cells

1992 • 2 citations