The role of calcium ions in toxic cell injury.

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction.

1985 • 300 citations

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

1986 • 249 citations

Altered thiol and calcium homeostasis in oxidative hepatocellular injury

1985 • 249 citations

tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1989 • 222 citations

Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle

1969 • 208 citations

Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes.

1985 • 196 citations

Prevention by chlorpromazine of ischemic liver cell death.

1977 • 188 citations

Mechanisms of the killing of cultured hepatocytes by hydrogen peroxide

1984 • 172 citations

Early, reversible plasma membrane injury in galactosamine-induced liver cell death.

1975 • 163 citations

Calcium-dependent and calcium-independent mechanisms of irreversible cell injury in cultured hepatocytes.

1986 • 149 citations

Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.

1984 • 133 citations

Increase in cytosolic Ca²⁺ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca²⁺ stores

1984 • 107 citations

On the relationship between Ca²⁺ efflux and membrane damage during t‐butylhydroperoxide metabolism by liver mitochondria

1983 • 93 citations

Mitochondrial glutathione status during Ca2+ ionophore-induced injury to isolated hepatocytes

1988 • 83 citations

Galactosamine-induced cell death in primary cultures of rat hepatocytes.

1980 • 52 citations

Calcium Reversal of Nerve Blockade by Alcohols, Anesthetics, Tranquilizers, and Barbiturates

1974 • 47 citations

The disruption of immunoglobulin caps by local anesthetics

1976 • 42 citations

Protection of rat hepatocytes from tert-butyl hydroperoxide-induced injury by catechol

1986 • 28 citations

Effect of antihistamines and chlorpromazine on the calcium-induced hyperpolarization of the Amphiuma red cell membrane

1976 • 23 citations

Effects of membrane stabilizers on pancreatic amylase release

1977 • 14 citations

THE ACTION OF GUANETHIDINE ON THE ADRENAL MEDULLA OF THE CAT

1968 • 5 citations