Activation of Transcriptionally Active Nuclear Factor-κB by Tumor Necrosis Factor-α and Its Inhibition by Antioxidants in Rat Thyroid FRTL-5 Cells¹

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition

1992 • 325 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro.

1992 • 146 citations

Characterization of Tumor Necrosis Factor-α Receptors in Human and Rat Thyroid Cells and Regulation of the Receptors by Thyrotropin*

1989 • 111 citations

NK-kappa B subunit-specific regulation of the I kappa B alpha promoter.

1994 • 110 citations

Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.

1996 • 109 citations

Analysis of cytokine gene expression in Graves' disease and multinodular goiter.

1994 • 103 citations

Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells.

1996 • 100 citations

Regulation of interleukin-6 release by human thyrocytes

1990 • 84 citations

High Potential to Tumor Necrosis Factor α (TNF-α) Production of Thyroid Infiltrating T Lymphocytes in Hashimoto's Thyroiditis: A Peculiar Feature of Destructive Thyroid Autoimmunity

1989 • 77 citations

Functional analysis of intercellular adhesion molecule‐1‐expressing human thyroid cells

1990 • 67 citations

Influence of Tumor Necrosis Factor-α on the Modulation by Interferon-γ of HLA Class II Molecules in Human Thyroid Cells and Its Effect on Interferon-γ Binding*

1989 • 59 citations

Constitutive and NF-κB—like proteins in the regulation of the serum amyloid a gene by interleukin 1

1991 • 57 citations

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.

1995 • 51 citations

Inhibition by N‐acetyl‐<scp>l</scp>‐cysteine of interleukin‐6 mRNA induction and activation of NFκB by tumor necrosis factor α in a mouse fibroblastic cell line, Balb/3T3

1994 • 50 citations

Induction of Rat Thyroid Cell MHC Class II Antigen by Thyrotropin and Y-Interferon*

1987 • 47 citations

Cloning of a Complementary Deoxyribonucleic Acid Coding for Human Thyroxine-Binding Globulin (TBG): Existence of Two TBG Messenger Ribonucleic Acid Species Possessing Different 3′-Untranslated Regions

1988 • 45 citations

Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages

1997 • 39 citations

Tumor necrosis factor-alpha activates nuclear factor kappa B and induces manganous superoxide dismutase and phosphodiesterase mRNA in human papillary thyroid carcinoma cells.

1992 • 39 citations

The mechanism of action of tumour necrosis factor-α and interleukin 1 on FRTL-5 rat thyroid cells

1990 • 33 citations

Tumor necrosis factor-α decreases thyrotropin-induced 5′-deiodinase activity in FRTL-5 thyroid cells

1994 • 31 citations

Influence of Cytokines on Growth and Differentiated Function of FRTL5 Cells*

1989 • 30 citations

Antioxidants Delay the Onset of Thyroiditis in Obese Strain Chickens*

1990 • 28 citations

Effects of Tumor Necrosis Factor-α, Interleukin-1β, and Interleukin-6 on Type I Iodothyronine 5′-Deiodination in Rat Thyroid Cell Line, FRTL-5

1995 • 28 citations

Expression of intercellular adhesion molecule-1 (ICAM-1) on human thyroid cell lines correlated with their binding of lymphoblasts

1990 • 20 citations

Factor(s) Present in Sera from Patients on Long-Term Hemodialysis lncrease(s) mRNAs for Collagenase and Stromelysin in Synovial Cells

1995 • 18 citations

In vitro effects of tumor necrosis factor-α on human thyroid follicular cells

1992 • 17 citations

Differential Induction of fos and jun Family Genes by Thyrotropin in Rat Thyroid FRTL-5 Cells

1996 • 11 citations

Effect of tumor necrosis factor on growth and function in FRTL5 cells.

1991 • 9 citations

Alterations in TNF-α Signal Transduction in Resistant Human Papillary Thyroid Carcinoma Cells

1996 • 8 citations